CAS: 6966-45-6; (4-Chlorophenyl)Methanesulfonyl Chloride

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4-氯苄溴置于sodium Hydroxide,Sodium Sulfite,氯化亚砜体系中,用 水,N,N-二甲基甲酰胺 作为反应溶剂,化学反应 7.0H,以77%的收率获得产物4-氯苯基甲磺酰氯
参考文献:设计,可持续合成和模板化的n-杂芳基乙烯基缩合乙烯基乙酰胺的程序化反应
标题:设计,可持续合成和模板化的n-杂芳基乙烯基缩合乙烯基乙酰胺的程序化反应
摘要:从头开始设计和合成n-杂芳基稠合的乙烯基sultams作为模板,用于编程在乙烯基sultam外围或(杂)芳基环上进行化学反应.关键特征包括模板的合理设计和可持续合成,在c═c键或涉及n-s键裂解的乙烯基sultams的定制反应以及杂芳基环外围的反应,用于后期分散.对模板的简单,便捷的访问,再加上从单个模板合成功能多样的杂环的机会,构成了当代有机合成中的一项罕有研究.
DOI:10.1021/acs.Joc.7B01340

专利信息

专利号:US-2006167268-A1
优先权日:2002-04-09
标 题:Growth hormone secretagogues
发明人：EVERS BRITTA; GERD RUEHTER; MARTIN DE LA NAVA EVA M; TEBBE MARK J
权利人:ELI LILLY AND COMPANY PATENT D
摘要:This invention relates to novel compounds which are useful in the modulation of endogenous growth hormone levels in a mammal. The invention further relates to novel intermediates for use in the synthesis of said compounds, as well as novel processes employed in these syntheses. Also included are methods of treating a mammal which include the administration of said compounds.

专利号:EP-1326851-B1
优先权日:2000-10-13
标 题 :Substituted dipeptides as growth hormone secretagogues
发明人：DODGE JEFFREY ALAN; EVERS BRITTA; JUNGHEIM LOUIS NICKOLAUS; MUEHL BRIAN STEPHEN; RUEHTER GERD; THRASHER KENNETH JEFF
权利人:LILLY CO ELI
摘要:This invention relates to novel compounds which are useful in the modulation of endogenous growth hormone levels in a mammal. The invention further relates to novel intermediates for usein the synthesis of said compounds, as well as novel processes employed in these syntheses. Also included are methods of treating a mammal which include the administration of said compounds.

专利号:EP-1836163-B1
优先权日:2004-12-23
标题 :Pyrrolidine derivatives for the treatment of a disease depending on the activity of renin
发明人：BREITENSTEIN WERNER; COTTENS SYLVAIN; EHRHARDT CLAUS; JACOBY EDGAR; LORTHIOIS EDWIGE LILIANE JEANNE; MAIBAUM JUERGEN KLAUS; OSTERMANN NILS; SELLNER HOLGER; SIMIC OLIVER
权利人:NOVARTIS AG
摘要:Novel 3-mono-, 3,4-di- and 3,4,4,-tri-substituted pyrrolidine compounds, these compounds for use in the diagnostic and therapeutic treatment of a warm-blooded animal, especially for the treatment of a disease (=disorder) that depends on inappropriate activity of renin; the use of a compound of that class for the preparation of a pharmaceutical formulation for the treatment of a disease that depends on inappropriate activity of renin; the use of a compound of that class in the treatment of a disease that depends on inappropriate activity of renin; pharmaceutical formulations comprising a said substituted pyrrolidine compound, and/or a method of treatment comprising administering a said substituted pyrrolidine compound, a method for the manufacture of said substituted pyrrolidine compounds, and novel intermediates and partial steps for their synthesis are described. The substituted pyrrolidine compounds are especially of the formula I wherein the substituents are as described in the specification.

专利号:US-7396846-B2
优先权日:2002-04-09
标题:Growth hormone secretagogues
发明人：EVERS BRITTA; GERD RUEHTER; MARTIN DE LA NAVA EVA MARIA; TEBBE MARK JOSEPH
权利人:LILLY CO ELI
摘要:This invention relates to novel compounds which are useful in the modulation of endogenous growth hormone levels in a mammal. The invention further relates to novel intermediates for use in the synthesis of said compounds, as well as novel processes employed in these syntheses. Also included are methods of treating a mammal which include the administration of said compounds.

专利号:US-7125840-B2
优先权日:2001-10-09
标题:Substituted dipeptides as growth hormone secretagogues
发明人：DODGE JEFFREY ALAN; EVERS BRITTA; JUNGHEIM LOUIS NICKOLAUS; MUEHL BRIAN STEPHEN; RUEHTER GERD; THRASHER KENNETH JEFF
权利人:LILLY CO ELI
摘要:This invention relates to novel compounds which are useful in the modulation of endogenous growth hormone levels in a mammal. The invention further relates to novel intermediates for use in the synthesis of said compounds, as well as novel processes employed in these syntheses. Also included are methods of treating a mammal which include the administration of said compounds.

专利号:CN-110105255-B
优先权日:2019-04-22
标 题 :Mild synthesis method of diaryl thioether