CAS: 76095-16-4; (S)-1-((S)-2-(((S)-1-Ethoxy-1-Oxo-4-Phenylbutan-2-yl)Amino)Propanoyl)Pyrrolidine-2-Carboxylic Acid Maleate

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CAS号110-16-7 马来酸 | CAS号147-85-3 脯氨酸 | CAS号75847-73-3 依那普利 | CAS号82717-96-2 N-[1-(S)-乙氧羰基-3... | CAS号103377-40-8 N-[1-(S)-ethoxy... | CAS号64920-29-2 2-氧代-基丁酸乙酯 | CAS号82009-36-7 N-[N-(1-(S)-eth... | CAS号2812-46-6 L-脯氨酸叔丁基酯 | CAS号80828-38-2 N-[(S)-1-(ethox... | CAS号76420-72-9 依那普利拉

专利信息

专利号:WO-2024213852-A1
优先权日:2023-04-12
标题:Electrochemical device for enzymatic synthesis of polynucleotides
发明人：HORGAN ADRIAN; FOURNIER MAXIME; GODRON XAVIER; BOUL MANON; CHEN SUYUE
权利人:DNA SCRIPT
摘要:The present invention relates to an electrochemical device (1) for enzymatic synthesis of polynucleotides, comprising at least one circulation duct (4) configured to receive an electrolytic solution, the circulation duct (4) being delimited by a first wall (6) and a second wall (7) opposite each other, the first wall (6) forming a support plate (8) of at least one reaction site configured for the enzymatic synthesis and able to carry a polynucleotide initiator fragment, the circulation duct (4) being equipped with a set of electrodes (2), the set of electrodes comprising at least one electrode of an array of electrodes (10) formed on the support plate (8) and operatively associated with the reaction sites, the set of electrodes (2) also comprising at least one additional electrode (16) arranged on the second wall (7) opposite the support plate (8).

专利号:US-10925977-B2
优先权日:2006-10-05
标 题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications
发明人：YANG DAVID J; YU DONGFANG; THOMPSON ANDREW S
权利人:YANG DAVID J; YU DONGFANG; THOMPSON ANDREW S; CEIL POINT LLC; UNIV TEXAS
摘要:Novel methods of synthesis of chelator-targeting ligand conjugates, compositions comprising such conjugates, and therapeutic and diagnostic applications of such conjugates are disclosed. The compositions include chelator-targeting ligand conjugates optionally chelated to one or more metal ions. Methods of synthesizing these compositions in high purity are also presented. Also disclosed are methods of imaging, treating and diagnosing disease in a subject using these novel compositions, such as methods of imaging a tumor within a subject and methods of diagnosing myocardial ischemia.

专利号:WO-2024133119-A1
优先权日:2022-12-19
标 题:Process for the synthesis of isophorone in the liquid phase, including recycling of the by-products
发明人：RUPPIN CHRISTOPHE
权利人:ARKEMA FRANCE
摘要:The present invention relates to a continuous process for the synthesis of isophorone in the liquid phase by alkaline self-condensation of acetone, comprising the following successive steps: a) continuously injecting, through a tubular reactor (R), a stream of an aqueous alkali hydroxide solution and a stream of an organic solution comprising acetone and by-products recycled in step g), followed by b) condensation reaction of the acetone in the tubular reactor (R), then c) distillation of the reaction mixture from the tubular reactor (R), then d) separation of the concentrated raw reaction product from the distillation of step c), resulting in an alkaline aqueous phase and an organic phase containing isophorone, then e) distillation of the organic phase containing the isophorone recovered in the preceding step, then f) distillation of the polycondensation sub-products from the bottom of the column (D2) from the preceding distillation, then g) recycling, to the tubular reactor (R), of the stream from the column head of the preceding distillation (D3), said stream comprising xylitones and/or isoxylitones.

专利号:US-7094920-B2
优先权日:2001-05-21
标 题 :Stereoselective synthesis of 2-hydroxy-4-phenylbutyric acid esters
发明人：TIKARE RAVEENDRA KHANDURAO
权利人:FERMENTA BIOTECH LTD
摘要:A process is described for the stereospecific preparation of an ester of formula (I): wherein * signifies the (R) stereoisomer; R 1 is selected from C 1-6 alkyl, preferably ethyl; and R 2 is hydrogen, a protecting group or a leaving group which process comprises reaction of a nitrile of formula (II): wherein * signifies the (R) stereoisonomer; and Ph is the phenyl group C 6 H 5 with a solution of an inorganic acid in an alcohol and optional conversion of the compound of formula (I) wherein R 2 is H so prepared to any other desired compound of formula (I) by standard methods in the art. The compounds of formula (I) are chiral esters, useful as intermediates in the synthesis of the family of acetylcholine esterase (ACE) inhibitors known as “prilsâ€?, such as lisinopril, cilazapril, enalapril, benazepril, ramipril, delapril, enalaprilat, imidapril, spirapril, trandolapril and others.n n*n nPh-CH 2 —CH 2 —CH(OR 2 )—COOR 1   (I)n n*n nPh-CH 2 —CH 2 —CH(H)—CN  (II)

专利号:WO-2025068673-A1
优先权日:2023-09-29
标 题 :Process for the synthesis of methanol with optimised syngas preparation and processing
发明人：YIU KAR CHI
权利人:JOHNSON MATTHEY DAVY TECHNOLOGIES LTD
摘要:A process for synthesising methanol is described comprising the steps of (i) reforming a hydrocarbon feedstock in a hydrocarbon reforming unit comprising a fired heater and an autothermal reformer in series to form a synthesis gas containing hydrogen, carbon monoxide and carbon dioxide; (ii) dividing the synthesis gas into a first portion and a second portion, (iii) converting the first portion of synthesis gas into a methanol product in a methanol synthesis unit comprising one or more methanol synthesis reactors; and (iv) recovering a purge gas stream from the methanol synthesis unit, wherein the second portion of synthesis gas is passed to a hydrogen production unit where it is subjected to one or more stages of water gas shift in a water-gas shift unit to form a hydrogen-enriched gas, the a hydrogen-enriched gas is subjected to a step of carbon dioxide removal in a carbon dioxide removal unit to form a hydrogen product stream and a carbon dioxide stream, the carbon dioxide stream is recovered and at least a portion of the hydrogen product stream is fed to the fired heater as a fuel.

专利号:WO-2024009192-A3
优先权日:2022-07-06
标 题:Method of homolytic and heterolytic cleavage in molecules of gases and liquids
发明人：CHERNOV GENNADIY
权利人:DEREROY & CO A S
摘要:The method is for homolytic and heterolytic cleavage in molecules of gases and liquids with the release of bonding energy and its use to change the internal geometric architecture of some molecules, leading to the synthesis of new chemical compounds that are not contained in the initial gases and liquids, with the secondary release of energy during the synthesis process, without carrying out nuclear reactions on equipment for its realization, characterised by an increase in the energy of the work environment and use of this energy to generate thermal energy with simultaneous synthesis of new chemical compounds, in consequence of the physical effect of a standing pressure wave on the gas and liquid molecules at various temperatures, where the temperature is a measure of activation energy, and subsequent dissociation of the molecules into atoms or fragments of molecules (radicals), partial ionization of atoms and subsequent transformation of the bonds in atoms of the molecules with no change to atomic number but with a change to atomic mass and in the proton-neutron ratio. The method also consists in the direct conversion of neutron mass into the mass equivalent to the total mass of 1 electron and 1 proton that do not go beyond the framework of the electrodynamic interaction of electrons and the nucleus, which ensures the absence of radiation, where the method also consists in the transformation of an atom into a chemical molecule or the reverse transformation of 1 electron and 1 proton into 1 neutron from the volume, where these elementary particles can be free, with external exchange of energy and mass equalling the mass with a positive charge and equal to the reduction in the mass of the neutron and proton. The method furthermore consists in a back reaction to the physical effect consisting in the formation of new chemical compounds that are not contained in the initial gases and liquids, with the release of the energy produced during the process of recombination of atoms into the original molecules, where the execution of the proposed method takes place through a combination of initial influences, such as for example : 12 C 1 H 4 = 16 Ne = 16 O, while the method further consists in rearranging the architecture of some molecules without changing the atomic number, mass number, atomic weight as a reaction to a physical impact, during which new chemical compounds are synthesized, including those that they are not contained in the initial gases and liquids, while the energy generated during these synthesis reactions is released, for example 14 N 2 = 12 C 16 O; 12 C 16 O 2 = 14 N 2 16 O. The proposed method is implemented by a combination of initial influences, such as: • increase in temperature of up to 250°C, ideally 140°C to 150°C; • reduction in pressure (creation of a reduced atmosphere) to -100 kPa, ideally -65 kPa; • generation of standing pressure waves; • electric discharge (tribostatic discharge, barrier, spark) with a breakdown voltage of 1 to 15 kV; • the value of the magnetic field in the reactor based on the discharge in the gas is 70 to 120 nTI; • micro-explosions; • impact, impact force, at which negative acceleration at from 50,000 to 150,000 g occurs; • or a combination of these influences. The apparatus for converting hydrocarbon and non-hydrocarbon gases and liquids consists of • an acceleration module, which is a piece of apparatus accelerating a mixture of gas and liquid up to a speed of 30 to 400 m/s; • a deceleration module, which is a tribostatic energy generator covering 70% to 90% of the reactor's cross-section; • a tribostatic generator, which consists of two electrodes which are placed side by side an on which positive and negative charges are mutually created; • a reduced atmosphere zone after the deceleration module.