118-90-1 = 87-24-1 反应条件:1.1 Reagents: Thionyl Chloride Solvents: Ethanol; 2 H,Reflux 标题:Synthesis And Antimicrobial Activity Of New Prenylated 2-Pyrone Derivatives 作者:Obi,Grace; Et Al 参考文献:Synthetic Communications 日期:2020 卷标:50(5) 页码:726-734]
= 87-24-1 反应条件:1.1 Reagents: Triethylamine Catalysts: 1638843-58-9 (Polystyrene Bounded); 3 H,1 Atm,70 °C 标题:Polymer Supported Pd Catalyzed Carbonylation Of Aryl Bromides For The Synthesis Of Aryl Esters And Amides 作者:Islam,Sk Manirul; Et Al 参考文献:Rsc Advances 日期:2014 卷标:4(73) 页码:38986-38999]
6091-64-1 = 87-24-1 反应条件:1.1 Reagents: Sec-Butyllithium Solvents: Tetrahydrofuran,Hexane,Cyclohexane; -48 °C1.2 Solvents: Tetrahydrofuran; -48 °C1.3 Reagents: Ammonium Chloride Solvents: Water 标题:A Flow Microreactor System Enables Organolithium Reactions Without Protecting Alkoxycarbonyl Groups 作者:Nagaki,Aiichiro; Et Al 参考文献:Chemistry - A European Journal 日期:2010 卷标:16(36) 页码:11167-11177]
1906-57-6 = 87-24-1 反应条件:1.1 Catalysts: 1,3-Bis(Diphenylphosphino)Propane,Palladium Trifluoroacetate Solvents: N-Methyl-2-Pyrrolidone; Rt; 24 H,145 - 155 °C 标题:Synthesis Of Aromatic Esters Via Pd-Catalyzed Decarboxylative Coupling Of Potassium Oxalate Monoesters With Aryl Bromides And Chlorides 作者:Shang,Rui; Et Al 参考文献:Journal Of The American Chemical Society 日期:2009 卷标:131(16) 页码:5738-5739]
161912-33-0 = 87-24-1 反应条件:1.1 Reagents: Sodium Acetate Catalysts: Palladium Diacetate,(1R)-1-[(1R)-1-[bis(1,1-Dimethylethyl)Phosphino]Ethyl]-2-(Diethylphosphino)Ferro... Solvents: Ethanol; 20 H,135 °C 标题:An Efficient Catalyst For Pd-Catalyzed Carbonylation Of Aryl Arenesulfonates 作者:Cai,Chaoxian; Et Al 参考文献:Organic Letters 日期:2006 卷标:8(22) 页码:5161-5164]
118-90-1 = 87-24-1 反应条件:1.1 Reagents: Diisopropylethylamine Solvents: Trihexyl(Tetradecyl)Phosphonium Bis(Trifluoromethylsulfonyl)Imide; 10 Min,30 °C1.2 12 H,30 °C 标题:Scope And Mechanistic Insights Into The Use Of Tetradecyl(Trihexyl)Phosphonium Bistriflimide: A Remarkably Selective Ionic Liquid Solvent For Substitution Reactions 作者:Mcnulty,James; Et Al 参考文献:Chemistry - A European Journal 日期:2006 卷标:12(36) 页码:9314-9322]
221635-86-5 = 87-24-1 反应条件:1.1 Solvents: Acetonitrile; 1 H,Rt; 72 H,Rt 标题:Photochemical Reactions Of 1,3,3-Trimethylbicyclo[2.2.2]Octa-5,7-Dien-2-Ones 作者:Chang,Shi-Yi; Et Al 参考文献:European Journal Of Organic Chemistry 日期:2006 卷标:(20) 页码:4648-4657]
529-20-4 = 87-24-1 反应条件:1.1 Reagents: Cesium Carbonate,Manganese Oxide (Mno2),1,8-Diazabicyclo[5.4.0]Undec-7-Ene Catalysts: 1-Butyl-3-Methylimidazolium Tetrafluoroborate Solvents: 1-Butyl-3-Methylimidazolium Tetrafluoroborate; Rt; 24 H,Rt 标题:The Dual Role Of Ionic Liquid Bmimbf4,Precursor Of N-Heterocyclic Carbene And Solvent,In The Oxidative Esterification Of Aldehydes 作者:Chiarotto,Isabella; Et Al 参考文献:Tetrahedron 日期:2013 卷标:69(37) 页码:8088-8095]
527-85-5 = 87-24-1 反应条件:1.1 Reagents: Hydrochloric Acid Catalysts: Ferric Chloride Hexahydrate Solvents: Hexane,Water; 14 H,80 °C1.2 Reagents: Sodium Chloride Solvents: Water; Neutralized 标题:Fe-Catalyzed Esterification Of Amides Via C-N Bond Activation 作者:Chen,Xiuling; Et Al 参考文献:Rsc Advances 日期:2018 卷标:8(9) 页码:4571-4576]
118-90-1 = 87-24-1 反应条件:1.1 Reagents: Sulfuric Acid Solvents: Ethanol; 12 H,Reflux; Reflux -> Rt1.2 Reagents: Sodium Carbonate Solvents: Water; Neutralized,Rt 标题:Smi2-Catalyzed Intermolecular Coupling Of Cyclopropyl Ketones And Alkynes: A Link Between Ketone Conformation And Reactivity 作者:Agasti,Soumitra; Et Al 参考文献:Journal Of The American Chemical Society 日期:2021 卷标:143(9) 页码:3655-3661]
118-90-1 = 87-24-1 反应条件:1.1 Catalysts: Sulfuric Acid; 13 H,110 - 120 °C 标题:A Simple,Efficient,Green,Cost Effective And Chemoselective Process For The Esterification Of Carboxylic Acids 作者:Rekha,Vamsi V.; Et Al 参考文献:Organic Process Research & Development 日期:2009 卷标:13(4) 页码:769-773]
6091-64-1 = 87-24-1 反应条件:1.1 Reagents: Zinc,Sodium Iodide Catalysts: Dichloro[1,1′-(1,3-Propanediyl)Bis[1,1-Diphenylphosphine-Kp]]Nickel Solvents: Tetrahydrofuran; 24 H,Rt 标题:Nickel-Catalyzed Methylation Of Aryl Halides With Deuterated Methyl Iodide 作者:Hu,Lu; Et Al 参考文献:Angewandte Chemie 日期:2016 卷标:55(33) 页码:9743-9747]
6091-64-1 = 87-24-1 反应条件:1.1 Reagents: Sec-Butyllithium Solvents: Tetrahydrofuran,Hexane,Cyclohexane; Rt -> -48 °C; 0.06 S,-48 °C1.2 Solvents: Tetrahydrofuran; 2.3 S,-48 °C1.3 Reagents: Hydrochloric Acid Solvents: Water; 30 S,Cooled 标题:Aryllithium Compounds Bearing Alkoxycarbonyl Groups: Generation And Reactions Using A Microflow System 作者:Nagaki,Aiichiro; Et Al 参考文献:Angewandte Chemie 日期:2008 卷标:47(41) 页码:7833-7836]
118-90-1 + 866-23-9 = 87-24-1 [标题:Reaction Conditions 标题:A High Yield Route To Ethyl Esters Of Carboxylic Acids 作者:Downie,Ian M.; Et Al 参考文献:Tetrahedron 日期:1982 卷标:38(10)]
615-37-2 = 87-24-1 反应条件:1.1 Reagents: 1,8-Diazabicyclo[5.4.0]Undec-7-Ene Catalysts: Palladium Diacetate Solvents: Ethanol; 10 Bar,Rt; Rt -> 125 °C; 20 Min,125 °C; 30 Bar,125 °C; 125 °C -> 50 °C; 20 Min,50 °C1.2 Reagents: Sodium Chloride Solvents: Diethyl Ether,Water; 50 °C 标题:Alkoxycarbonylation Of Aryl Iodides Using Gaseous Carbon Monoxide And Pre-Pressurized Reaction Vessels In Conjunction With Microwave Heating 作者:Kormos,Chad M.; Et Al 参考文献:Organic & Biomolecular Chemistry 日期:2007 卷标:5(1) 页码:65-68]
615-37-2 = 87-24-1 反应条件:1.1 Catalysts: Dichlorobis(Triphenylphosphine)Palladium Solvents: Tetrahydrofuran 标题:Transition Metal Complex Catalyzed Carbonylation Of Organic Halides In The Presence Of Molecular Sieves Instead Of Base 作者:Urata,Hisao; Et Al 参考文献:Tetrahedron Letters 日期:1991 卷标:32(36) 页码:4733-6]
28276-79-1 = 87-24-1 反应条件:1.1 Reagents: Hydrogen Catalysts: Palladium Solvents: Ethanol; 8 H,55 °C 标题:Licl-Promoted Pd(Ii)-Catalyzed Ortho Carbonylation Of N,N-Dimethylbenzylamines 作者:Li,Hu; Et Al 参考文献:Dalton Transactions 日期:2010 卷标:39(43) 页码:10442-10446]
118-90-1 = 87-24-1 反应条件:1.1 Reagents: Diisopropylethylamine Solvents: Trihexyl(Tetradecyl)Phosphonium Bis(Trifluoromethylsulfonyl)Imide; 10 Min,30 °C1.2 12 H,30 °C 标题:A Mild Esterification Process In Phosphonium Salt Ionic Liquid 作者:Mcnulty,James; Et Al 参考文献:Tetrahedron Letters 日期:2005 卷标:46(21) 页码:3641-3644]
635-26-7 = 87-24-1 反应条件:1.1 Reagents: Triethylamine,Potassium Iodide,Oxygen Catalysts: Palladium; 12 H,3 Bar,100 °C 标题:Tunable Pd/c-Catalyzed Oxidative Alkoxycarbonylation/aminocarbonylation Of Aryl Hydrazines With Alcohols/inert Tertiary Amines Through C-N Bond Activation 作者:Kolekar,Yuvraj A.; Et Al 参考文献:New Journal Of Chemistry 日期:2022 卷标:46(30) 页码:14421-14426]
= 87-24-1 反应条件:1.1 Reagents: Manganese Catalysts: Chlorotrimethylsilane,2,2′-Bipyridine,Cobalt Dibromide Solvents: Dimethylformamide,Pyridine; 20 H,60 °C 标题:Cobalt-Catalyzed Esterification Of Amides 作者:Bourne-Branchu,Yann; Et Al 参考文献:Chemistry - A European Journal 日期:2017 卷标:23(42) 页码:10043-10047]
615-37-2 + 1906-57-6 = 87-24-1 反应条件:1.1 Catalysts: Palladium Diacetate Solvents: N-Methyl-2-Pyrrolidone; 24 H,140 °C; 140 °C -> Rt 标题:Ligand Free Palladium Catalyzed Decarboxylative Cross-Coupling Of Aryl Halides With Oxalate Monoester Salts 作者:Li,Yan; Et Al 参考文献:Tetrahedron Letters 日期:2012 卷标:53(43) 页码:5796-5799]
16419-60-6 + 1609-47-8 = 87-24-1 反应条件:1.1 Reagents: Sodium Carbonate Catalysts: Triphenylphosphine,Palladium Diacetate Solvents: 1,4-Dioxane; 16 H,110 °C 标题:Palladium-Catalyzed Carbonylations Of Arylboronic Acids: Synthesis Of Arylcarboxylic Acid Ethyl Esters 作者:Liang,Apeng; Et Al 参考文献:Advanced Synthesis & Catalysis 日期:2015 卷标:357(14-15) 页码:3104-3108]
529-20-4 = 87-24-1 反应条件:1.1 Reagents: Acetone Catalysts: Palladium Diacetate,X-Phos; 20 Min,Rt1.2 Catalysts: Potassium Carbonate; 20 Min,Rt1.3 Overnight,50 °C 标题:Pd-Catalyzed Aldehyde To Ester Conversion: A Hydrogen Transfer Approach 作者:Tschaen,Brittany A.; Et Al 参考文献:Organic Letters 日期:2013 卷标:15(3) 页码:500-503]
14683-79-5 = 87-24-1 反应条件:1.1 Reagents: Hydrogen Peroxide Catalysts: 2-Nitrobenzeneseleninic Acid Solvents: Water; Rt 标题:O-Nitrobenzeneseleninic Acid 作者:Renga,James M. 参考文献:E-Eros Encyclopedia Of Reagents For Organic Synthesis 日期:2001 卷标:1
专利号:US-6048991-A 优先权日:1990-11-16 标题:Preparation of epoxides 发明人:HAERMELING DIETER 权利人:BASF AG 摘要:Alpha-hydroxy-epoxides of alpha-alkoxy-epoxides of the formula IV ##STR1## in which the substituents have the following meanings: R 7 , R 8 , R 9 , R 10 , R 11 are independently hydrogen, C 1 -C 20 -alkyl, C 3 -C 12 -cycloalkyl, C 4 -C 20 -cycloalkylalkyl, C 1 -C 20 -hydroxy-alkyl, a heterocyclic ring, or an aryl or C 7 -C 20 -arylalkyl group optionally substituted by C 1 -C 8 -alkyl, C 1 -C 8 -alkoxy, halogen, C 1 -C 4 -haloalkyl, C 1 -C 4 -halo-alkoxy, phenyl, phenoxy, halophenyl, halophenoxy, carboxy, C 2 -C 8 -alkoxycarbonyl, or cyano, or R 7 and R 8 or R 7 and R 9 or R 7 and R 10 or R 9 and R 10 or R 10 and R 11 together form a (CH 2 ) n group in which n is an integer from 1 to 10 and which may be optionally substituted by C 1 -C 8 -alkyl, C 1 -C 8 -alkoxy, and/or halogen, and n R 12 is hydrogen, C 1 -C 8 -alkyl, or benzyl, n provided that R 10 is not hydrogen, methyl, ethyl, propyl, or cyclohexyl when R 7 , R 8 , R 9 , or R 11 is hydrogen, that R 7 is not methyl when R 8 is methyl or phenyl and R 9 , R 10 , or R 11 is hydrogen, that R 7 is not methyl when R 8 , R 9 , R 10 , or R 11 is hydrogen and R 12 is ethyl, that R 7 is not phenyl or hexyl when R 8 , R 9 , R 10 , or R 11 is hydrogen, that R 9 is not methyl when R 7 , R 8 , R 10 , or R 11 is hydrogen, that R 10 and R 11 are not methyl when R 7 , R 8 , or R 9 is hydrogen, and that R 7 and R 10 do not together form an unsubstituted cycloalkyl when R 8 , R 9 , or R 11 is hydrogen. The epoxides of the above formula serve as intermediates for the synthesis of, inter alia, perfumes, plant protectants and polymers.
专利号:US-2004053999-A1 优先权日:1997-09-17 标题 :Novel compounds and methods for synthesis and therapy 发明人:BISCHOFBERGER NORBERT W; DAHL TERRENCE C; HITCHCOCK MICHAEL J M; KIM CHOUNG U; LEW WILLARD; LIU HONGTAO; MILLS ROGER G; WILLIAMS MATTHEW A 摘要:Novel compounds are described. The compounds generally comprise an acidic group, a basic group, a substituted amino or N-acyl and a group having an optionally hydroxylated alkane moiety. Pharmaceutical compositions comprising the inhibitors of the invention are also described. Methods of inhibiting neuraminidase in samples suspected of containing neuraminidase are also described. Antigenic materials, polymers, antibodies, conjugates of the compounds of the invention with labels, and assay methods for detecting neuraminidase activity are also described.
专利号:CN-105131041-B 优先权日:2015-09-15 标 题 :A novel triphenyl organic bismuth (V) complex catalyst, its preparation method and its catalytic application in the synthesis of nitrogen-containing compounds
专利号:US-4329349-A 优先权日:1979-07-25 标 题:6-C1-4 Alkyl-7-phenyl or substituted phenyl-1,6-naphthyridine-5(6H)-ones 发明人:DAMON II ROBERT E; NADELSON JEFFREY 权利人:SANDOZ AG 摘要:Compounds of the formula ##STR1## and pharmaceutically acceptable acid addition salts thereof, wherein n R 1 is C 1-4 alkyl, n R 2 is hydrogen, C 1-4 alkyl, C 1-4 alkoxy, halo, trifluoromethyl, C 1-4 alkylthio or --NR 5 R 6 , wherein each of R 5 and R 6 is independently hydrogen or C 1-3 alkyl, n R 3 is hydrogen, C 1-3 alkyl, C 1-3 alkoxy, halo or trifluoromethyl, and n R 4 is hydrogen, C 1-3 alkyl, C 1-3 alkoxy or halo, n their use as muscle relaxants and as anti-inflammatory agents, pharmaceutical compositions comprising them, processes for their synthesis and compounds of the formulae ##STR2## wherein R 1 , R 2 , R 3 and R 4 are as defined above, useful as intermediates in their synthesis.
专利号:US-2008063720-A1 优先权日:2004-04-29 标 题:Delivery System 发明人:GOUNKO IOURI K; RAKOVICH YURY; VOLKOV YURI; DONGEGAN JOHN; KELLEHER DERMOT; MITCHELL SIOBHAN 权利人:GOUNKO IOURI K; RAKOVICH YURY; VOLKOV YURI; DONGEGAN JOHN; KELLEHER DERMOT; MITCHELL SIOBHAN 摘要:Therapeutic drug delivery and diagnostics systems comprise biologically active compounds associated with particulate carriers of less than 20 nm. These systems can be utilised for targeted modification of growth, development and functions, such as gene expression, protein synthesis, intracellular energy production and transport mechanisms in prokaryotic and eukaryotic organisms. The systems are also applicable for controlled modification of structural and functional properties of extracellular components and tissue constituents. The characteristics of a biological site are evaluated and an entity is provided which is dependent on the site characteristics. The entity comprises nanoparticles of less than 20 nm. A probe comprising nanoparticles of less than 5 nm is also provided.
专利号:WO-9314086-A1 优先权日:1992-01-17 标 题 :Substituted 1-isoquinolone derivatives as angiotensin ii antagonists 发明人:FISHER LAWRENCE E; CAROON JOAN M; STABLER STEPHEN R; CLARK ROBIN D 权利人:SYNTEX INC 摘要:1-Isoquinolone derivatives and related compounds according to formula (I) wherein, Y is selected from the group consisting of H, OH, lower alkoxy, and halo; X is selected from the group consisting of H, lower alkyl acid, lower alkyl ester, and lower alkyl; and R1 is selected from the group consisting of H, alkenyl, lower alkyl, lower cycloalkyl, unsubstituted or substituted 3-spiro-1H-indane of structure (II) wherein R2 is H, OH, lower alkyl, lower alkoxy or halo, and 3-spiro-cycloalkyl of structure (III) wherein n is an integer from zero to six, provided that when R1 is spiro- X is H, or a pharmaceutically acceptable salt thereof, with the proviso that when R1 is spiro-, X is H, and when R1 is H, alkenyl, lower alkyl or lower cycloalkyl substituted at the 3-position of the isoquinolone moiety and X is H or lower alkyl, the (2'-1H--tetrazol-5-yl)biphenyl-4'-ylmethyl group cannot be at the 2(N) position, are useful as angiotensin II receptor antagonists. Also disclosed are methods of synthesis, intermediates, pharmaceutical formulations and methods of treatment.
摘要:Li, G.; Szostak, M., Science of Synthesis Knowledge Updates, (2020) 2, 231. 摘要:Stanforth, S. P., Science of Synthesis Knowledge Updates, (2015) 1, 180. 摘要:Stanforth, S. P., Science of Synthesis Knowledge Updates, (2015) 1, 215. 摘要:Sanford, M. S.; Cook, A., Science of Synthesis: Catalytic Transformations via CH Activation, (2015) 2, 199. 摘要:Satoh, T.; Miura, M., Science of Synthesis: Catalytic Transformations via CH Activation, (2015) 1, 202.