CAS: 88-15-3; 1-Thiophen-2-Yl-Ethanone

上下游产品

thiophene acetyl iodide acetoxytrichlorosilane trifluoroacetic anhydride 1-[2-oxo-2-(thiophen-2-yl)ethyl]pyridinium iodide (2E,4E)-5-phenyl-1-(thiophen-2-yl)penta-2,4-dien-1-one 3-(dimethylamino)-1-(thiophen-2-yl)propan-1-one hydr°Chloride 3-(morpholin-4-yl)-1-(thiophen-2-yl)propan-1-one

2-乙炔噻吩置于1-Hydroxytetraphenylcyclopentadienyl(Tetraphenyl-2,4-Cyclopentadien-1-One)-μ-Hydrotetracarbonyldiruthenium(II),水,苯胺,Sodium Chloride体系中,化学反应 1.0H,以90%的收率获得产物2-乙酰基噻吩
参考文献:钌纳米粒子催化下的水中马尔可夫尼科夫水合和末端炔的一锅还原加氢胺化
标题:钌纳米粒子催化下的水中马尔可夫尼科夫水合和末端炔的一锅还原加氢胺化
摘要:在shvo催化剂[2,3,4,5-四苯基-1,3-环戊二烯-1-醇,钌(II)配合物]存在下,少量苯胺和tgps-750-M表面活性剂,末端炔烃在微波(mw)电介质加热下以水作为反应溶剂水合,转化率高,收率高.与钌络合物通常观测到的反应不同,该反应仅产生马尔可夫尼科夫产物.在mws的影响下,形成了嵌入纳米胶束环境的ru纳米颗粒,作为有效的水合催化剂.在水相中引入甲酸钠并使用化学计量的胺,Ru纳米颗粒纳米胶束催化剂是炔烃单步单步加氢胺化并形成相应仲胺的第一个实例.
DOI:10.1002/ejic.201901235

专利信息

专利号:US-9388131-B2
优先权日:2011-04-27
标题:Automated synthesis of small molecules using chiral, non-racemic boronates
发明人：BURKE MARTIN D; LI JUNQI; GILLIS ERIC P
权利人:UNIV ILLINOIS
摘要:Provided are methods for making and using chiral, non-racemic protected organoboronic acids, including pinene-derived iminodiacetic acid (PIDA) boronates, to direct and enable stereoselective synthesis of organic molecules. Also provided are methods for purifying PIDA boronates from solution. Also provided are methods for deprotection of boronic acids from their PIDA ligands. The purification and deprotection methods may be used in conjunction with methods for coupling or otherwise reacting boronic acids. Iterative cycles of deprotection, coupling, and purification can be performed to synthesize chiral, non-racemic compounds. The methods are suitable for use in an automated chemical synthesis process. Also provided is an automated small molecule synthesizer apparatus for performing automated stereoselective synthesis of chiral, non-racemic small molecules using iterative cycles of deprotection, coupling, and purification.

专利号:US-2004249170-A1
优先权日:2002-01-24
标 题 :Process for preparing an intermediate useful for the asymmetric synthesis of duloxetine
发明人：BORGHESE ALFIO
摘要:This invention provides a process for the synthesis of(S)-3-Methylamino-1-2-thienyl)-1-propanol, a key intermediate in the synthesis of duloxetine.

专利号:US-5491243-A
优先权日:1993-10-12
标题 :Intermediate useful for the asymmetric synthesis of duloxetine
发明人：BERGLUND RICHARD A
权利人:LILLY CO ELI
摘要:This invention provides a stereospecific process for the synthesis of (S)-(+)-N,N-dimethyl-3-(1-naphthalenyloxy)-3-(2-thienyl)propanamine, a key intermediate in the synthesis of duloxetine.

专利号:US-8192590-B1
优先权日:2008-04-14
标 题:Microwave-assisted formation of sulfonium photoacid generators
发明人：BELFIELD KEVIN D; YANEZ CICERON O
权利人:BELFIELD KEVIN D; YANEZ CICERON O; UNIV CENTRAL FLORIDA RES FOUND
摘要:Efficient method for preparing sulfonium photoacid generators (PAGs) by microwave-assisted reaction of diarylsufides in the presence of alkylaryliodonium salts. Microwave-assisted synthesis of the PAGs is significantly faster, reducing reaction time with less energy consumption. Reaction times using the microwave-assisted synthesis are in a range of from 90 to 420 faster than conventional thermal conditions. The photoacid quantum yields of several salts prepared by the microwave reaction were measured; the photoacid quantum yields of new sulfonium PAGs were in a range from 0.01 to 0.4 times greater than yields from conventional synthesis. Incorporating a nitro group in the structures of the sulfonium salts increased photoacid quantum yield, induced intersystem crossing and increased the efficiency of photoacid generation compounds.

专利号:US-2009076268-A1
优先权日:2007-09-14
标 题:Facile assembly of fused benzofuro-heterocycles
发明人：FITZGERALD ANNE E; LIU JING; MANI NEELAKANDHA S
权利人:FITZGERALD ANNE E; LIU JING; MANI NEELAKANDHA S
摘要:This invention concerns the synthesis of polycyclic structural components of pharmacological compounds, including the synthesis of fused benzofuro-heterocycles, through selective palladium-catalyzed cross-coupling and intramolecular cyclization.

专利号:US-2011281893-A1
优先权日:2010-05-11
标 题 :Compound, synthesis, composition and uses thereof
发明人：KANDULA MAHESH
权利人:KANDULA MAHESH; KRISANI BIOSCIENCES P LTD
摘要:The instant application provides the disclosure for a compound of formula I, synthesis of compound of formula I and its pharmaceutical acceptable salts, as well as its polymorphs, solvates, and hydrates thereof. The pharmaceutically acceptable salt may be formulated for oral administration, systemic administration, transdermal administration and injection. The compound of formula I and its pharmaceutical compositions may be used to treat cancer in mammal.