CAS: 1131-94-8; 2-(3-Hydroxy-4-Methoxyphenyl)Acetic Acid

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2-(4-甲氧基-3-硝基苯基)乙酸置于甲醇,硫酸,钯,Sodium Nitrite体系中,化学反应生成3-羟基-4-甲氧基苯乙酸
参考文献:Some Derivatives Of Homoanisic Acid
标题:Some Derivatives Of Homoanisic Acid
摘要:
Doi:10.1021/jo01212A006

专利信息

专利号:US-8461384-B2
优先权日:2006-12-11
标 题 :Preparation of amides from an acid and amine for intermediates in the synthesis of morphinans
发明人：WANG PETER X; MOSER FRANK W; GROTE CHRISTOPHER W; CANTRELL GARY L
权利人:WANG PETER X; MOSER FRANK W; GROTE CHRISTOPHER W; CANTRELL GARY L; MALLINCKRODT LLC
摘要:The present invention is directed to processes for the synthesis of morphinans. In particular, a process for coupling a carboxylic acid compound with an amine compound to form an amide product that can then be isolated or the crude amide product can be cyclized to form a 3,4-dihydroisoquinoline. In one embodiment, the carboxylic acid contains a phenol moiety protected with a labile protecting group. The protected phenol reduces reaction times, simplifies work-up of the product, and reduces the amount of cyclizing agent, POCl 3 that is necessary to form the 3,4-dihydroisoquinoline.

专利号:US-9453037-B2
优先权日:2011-07-28
标 题 :Methylphenidate-prodrugs, processes of making and using the same
发明人：GUENTHER SVEN; CHI GUOCHEN; BERA BINDU; MICKLE TRAVIS; BERA SANJIB
权利人:KEMPHARM INC; KEMPHARM INC
摘要:The present technology is directed to prodrugs and compositions for the treatment of various diseases and/or disorders comprising methylphenidate, or methylphenidate derivatives, conjugated to at least one alcohol, amine, oxoacid, thiol, or derivatives thereof. In some embodiments, the conjugates further include at least one linker. The present technology also relates to the synthesis of methylphenidate, or methylphenidate derivatives, conjugated to at least one alcohol, amine, oxoacid, thiol, or derivatives thereof or combinations thereof.

专利号:US-2009247761-A1
优先权日:2006-12-11
标 题:Preparation of 3,4-Dihydroisoquinolines in the Synthesis of Morphinans

专利号:US-2012016390-A1
优先权日:2010-07-16
标 题 :Bioadhesive compounds and methods of synthesis and use
发明人：LEE BRUCE P; MURPHY JOHN L; VOLLENWEIDER LAURA; DALSIN JEFFREY L; LYMAN ARINNE N
权利人:LEE BRUCE P; MURPHY JOHN L; VOLLENWEIDER LAURA; DALSIN JEFFREY L; LYMAN ARINNE N; KNC NER ACQUISITION SUB INC
摘要:The invention describes new synthetic medical adhesives and antifouling coatings which exploit the key components of natural marine mussel adhesive proteins.

专利号:US-8232400-B2
优先权日:2006-12-11
标 题 :Preparation of 3,4-dihydroisoquinolines in the synthesis of morphinans

专利号:EP-2161253-A2
优先权日:2006-12-11
标 题 :Process for the preparation of 3,4-dihydroisoquinolines in the synthesis of morphinans