CAS: 1851-22-5; 3-Chloropyridine 1-Oxide

上下游产品

CAS号626-60-8 3-氯吡啶 | CAS号38180-46-0 3-氯-2-氰吡啶 | CAS号89809-64-3 2-氰基-5-氯吡啶 | CAS号626-60-8 3-氯吡啶 | CAS号76439-45-7 3-氯-4-硝基吡啶-N-氧化物 | CAS号5897-94-9 3-氯吡啶-2-硫醇 | CAS号16110-09-1 2,5-二氯吡啶 | CAS号2402-77-9 2,3-二氯吡啶 | CAS号55934-00-4 3,4-二氯吡啶 | CAS号636-73-7 3-吡啶磺酸 | CAS号1072-98-6 2-氨基-5-氯吡啶

3-氯吡啶置于双氧水体系中,用 甲醇 用作溶剂,化学反应 0.05H,以99%的收率获得3-氯吡啶-N-氧化物
参考文献:连续流微反应器促进吡啶衍生物的催化n-氧化反应
标题:连续流微反应器促进吡啶衍生物的催化n-氧化反应
摘要:成功构建了一个简单的连续流动微反应器,用于吡啶的n-氧化.连续流动微反应器使用填充床微反应器中的钛硅沸石 (Ts-1) 和 H 2 O 2 (在甲醇中作用作溶剂)作为催化氧化系统,以高达 99% 的收率形成各种吡啶n-氧化物.与使用间歇反应器相比,该工艺是一种更安全,更环保,更高效的工艺.该装置连续运行800小时以上,催化剂保持非常好的活性,为规模化生产提供了巨大潜力.
Doi:10.1055/s-0041-1737490

专利信息

专利号:US-3886180-A
优先权日:1973-03-15
标 题:Process for the synthesis of N-hydroxypyrroles
发明人：ABRAMOVITCH RUDOLPH ABRAHAM; CUE JR BERKELEY WENDELL
权利人:ABRAMOVITCH RUDOLPH ABRAHAM; CUE JR BERKELEY WENDELL
摘要:A process is described for the preparation of N-hydroxypyrrole2-carbonitriles, N-hydroxyimidazole-2-carbonitriles, pyrrole-2carbonitriles, and 3-substituted-2, 3-dihydro-2-pyrrolones by thermally decomposing 2-azidoheteroaromatic N-oxides. In the process a 2-azidoheteroaromatic N-oxide is heated in a suitable solvent for a period of time sufficient to bring the reaction to completion. Removal of the solvent by conventional methods gives the desired product. Which product is obtained is determined by the choice of solvents. In non-polar aprotic solvents, Nhydroxypyrrole-2-carbonitriles or N-hydroxyimidazole-2carbonitriles are obtained. In nucleophilic solvents capable of undergoing Michael-type additions pyrrole-2-carbonitriles, imidazole-2-carbonitriles, and 3-substituted-2,3-dihydro-2pyrrolone derivatives are obtained where a solvent molecule comprises the 3-substituent. These compounds are useful as antibaterials, e.g., against E. Coli.

专利号:CN-115160220-A
优先权日:2022-08-06
标 题 :A kind of synthesis technique of pyridine-N-oxide