CAS: 27387-31-1; 1,2,3,9-Tetrahydro-9-Methyl-4H-Carbazole-4-One

上下游产品

CAS号15128-52-6 1,2,3,4-四氢咔唑-4-酮 | CAS号74-88-4 碘甲烷 | CAS号1373402-37-9 3-(methylamino)... | CAS号77-78-1 硫酸二甲酯 | CAS号6303-88-4 1H-Carbazole,2,... | CAS号124907-00-2 3-((2-FLUOROPHE... | CAS号57466-25-8 N-methyl-N-phen... | CAS号56964-05-7 2-phenylcyclohe... | CAS号4637-24-5 N,N-二甲基甲酰胺二甲基缩醛 | CAS号99614-01-4 Ondansetron HCl | CAS号99614-64-9 1,2,3,9-四氢-9甲基-... | CAS号99614-02-5 昂丹司琼 | CAS号132666-57-0 N,N-dimethyl-1-... | CAS号173594-86-0 4-氯-9-甲基-2,9-二氢... | CAS号59943-49-6 5H-Pyrimido[5,4... | CAS号38942-83-5 9-methyl-3-(mor...

2,3,4,9-四氢-9-甲基-1H-咔唑置于2,3-二氯-5,6-二氰基-1,4-苯醌体系中,用 四氢呋喃,水 用作溶剂,化学反应 2.0H,以61%的收率获得1,2,3,4-四氢-9-甲基-4H-咔唑酮
参考文献:通过费歇尔 吲哚化和烯烃易位的吲哚并咔唑的多样性导向方法:齐帕唑d和i的全合成†
标题:通过费歇尔 吲哚化和烯烃易位的吲哚并咔唑的多样性导向方法:齐帕唑d和i的全合成†
摘要:已经报道了在绿色条件下使用l-(+)-酒石酸和n,N-二甲基尿素通过费歇尔吲哚化的两倍进行合成吲哚并咔唑的新策略.从一种台式起始原料环己酮开始,该方法已扩展到天然产物的合成,如替帕帕唑d和i,以及紫杉醇和消旋素b的核心结构..在这里,诸如闭环复分解,烯炔复分解和diels-alder反应之类的原子经济反应已被用作关键步骤.此处展示的多种策略在药物化学和材料科学中用于设计修饰的吲哚文库是有用的.
Doi:10.1039/c6Ob01679K

专利信息

专利号:US-5478949-A
优先权日:1992-10-14
标 题 :Process for preparing ondansetron
发明人：BOD PETER; HARSANYI KALMAN; TRISCHLER FERENC; FEKECS EVA; CSEHI ATTILA; HEGEDUES BELA; MERSICH NEE DONAT EVA; SZABO NEE KOMLOSI GYOERGYI; HORVATH NEE SZIKI ERIKA
权利人:RICHTER GEDEON VEGYESZET
摘要:The invention relates to carbazolone derivatives of the formula ##STR1## wherein A stands for a group of formula n n --CH.sub.2 --R (V), n n wherein R means a hydroxyl or 2-methyl-1H-imidazol-1-yl group; n B represents a group of formula ##STR2## wherein R 1 means hydrogen or a methyl or ethyl group; or A and B together form a group of formula ##STR3## wherein R 2 means a methyl or ethyl group; or A and B together form a group of formula ##STR4## The above compounds are useful intermediates in the synthesis of ondansetron of formula ##STR5## chemically 9-methyl-3-[(2-methyl-1H-imidazol-1-yl)methyl]-1,2,3,9-tetrahydro-4H-carbazol-4-one. n The invention further relates to a novel process for the preparation of compounds of the formula (I) , wherein A and B are the same as in formula (I) but B may be also hydrogen. Thus, this novel process is suitable for the preparation of ondansetron itself.

专利号:RU-2119914-C1
优先权日:1992-10-14
标题 :Derivatives of carbazolone and method of their synthesis

专利号:RU-2041876-C1
优先权日:1993-12-29
标 题:Process for preparing 1,2,3,9-tetrahydro -9-methyl -3-[(2-methyl-1h-imidazol -1-yl)methyl]-4h- carbazol-4-one or salts thereof or hydrates thereof, and intermediate products of synthesis thereof

专利号:CN-115677560-B
优先权日:2022-11-01
标题:Synthesis method of 1,2,3,9-tetrahydro-9-methyl-4H-carbazole-4-one