CAS: 345-29-9; 4-Fluoro-2-Hydroxybenzoic Acid

上下游产品

4-氟水杨酸甲酯 Methyl 4-Fluoro-2-Hydroxybenzoate 392-04-1
4-氟-2-甲氧基苯甲酸 4-Fluoro-2-Methoxy-Benzoic Acid 395-82-4
4-氟-2-羟基苯甲醛 4-Fluoro-2-Hydroxybenzaldehyde 348-28-7
3-Chloro-4-Fluoro-2-Hydroxybenzoic Acid 860296-14-6
4-氟-2-甲氧基苯甲醛 4-Fluoro-2-Methoxybenzaldehyde 450-83-9
4-氨基水杨酸 4-Aminosalicylic Acid 65-49-6
对氟苯甲酸 4-Fluorobenzoic Acid 456-22-4

对氟苯甲酸置于叔丁基过氧化氢,N-乙酰-L-异亮氨酸,Potassium Acetate,Palladium Diacetate,对苯醌体系中,用 乙二醇二甲醚,水 作为反应溶剂,以68%的收率获得产物4-氟水杨酸
参考文献:钯催化的苯甲酸邻位 Ch 羟基化
标题:钯催化的苯甲酸邻位 Ch 羟基化
摘要:已经探索了使用 Tbhp 作为唯一氧化剂的简单 Pd(Oac) 2催化苯甲酸邻羟基化反应.该协议具有相对广泛的基板范围和操作简单性.邻位取代底物的相容性是对先前邻位羟基化反应的有效补充.
DOI:10.1016/j.Tetlet.2021.153434

专利信息

专利号:EP-2336114-B1
优先权日:2007-12-07
标题 :Process for the synthesis of l-3,4 dihydroxy-6-[18f]fluoro-phenylalanine and 2-[18f]fluor-l-tyrosine and their alpha-methylated derivatives starting from a precursor
发明人：WAGNER FRANZISKA; ERMERT JOHANNES; COENEN HEINRICH HUBERT
权利人:FORSCHUNGSZENTRUM JUELICH GMBH
摘要:Substituted benzaldehyde compounds (I), are new. Substituted benzaldehyde compounds of formula (I), is new. X : H or CH 3; R 5>nucleophilic leaving group e.g. B, F, Br, Cl, NO 2or -N(R) 3 +>; R : alkyl e.g. CH 3or C 2H 5; R 2>benzyl or methyl; and R 4>(S)-1-(tert-butoxycarbonyl)-2-tert-butyl-3-methyl-4-imidazolidinone, (S)-1-(benzoylcarbonyl)-2-tert-butyl-3-methyl-4-imidazolidinone, (S)-tert-butyl-2-tert-butyl-4-methoxy-2,5-dihydroimidazol-1-carboxylate, (2S,5R)-tert-butyl-2-tert-butyl-3,5-dimethyl-4-oxoimidazolidin-1-carboxylate, (S)-1-(benzoylcarbonyl)-2-tert-butyl-3,5-dimethyl-4-imidazolidinone or (S)-tert-butyl-2-tert-butyl-5-methyl-4-methoxy-2-hydroimidazol-1-carboxylate. Independent claims are included for: (1) the preparation of (I); and (2) preparing L-3,4-dihydroxy-6-[18F]fluorophenylalanine compound of formula (II) and 2-[18F]fluoro-L-tyrosine compound of formula (III), comprising [18F]-fluorinating (I), separating the fluorinated compound in which the fluorinated compound is oxidized to give (II) or decarbonylated to give (III), and hydrolyzing and separating the respective products. [Image] [Image].

专利号:EP-2336114-A1
优先权日:2007-12-07
标 题:Process for the synthesis of L-3,4 dihydroxy-6-[18F]fluoro-phenylalanine and 2-[18F]Fluor-L-tyrosine and their alpha-methylated derivatives starting from a precursor

专利号:CN-115679363-A
优先权日:2022-10-12
标 题 :Synthesis of bifunctional fluorine-doped armor-type nanomaterials by organic-inorganic hybrid method, preparation method and application

专利号:US-7189749-B2
优先权日:1999-06-25
标 题 :Substituted phenoxyacetic acids
发明人：VAN ZANDT MICHAEL C
权利人:INST FOR PHARM DISCOVERY INC
摘要:Disclosed are substituted phenoxyacetic acids useful in the treatment of chronic complications arising from diabetes mellitus. Also disclosed are pharmaceutical compositions containing the compounds, alone or in combination with other therapeutic agents, and methods of treatment employing the compounds and pharmaceutical compositions, as well as methods for their synthesis.

专利号:US-7737166-B2
优先权日:2005-08-17
标 题:Antifungal bicyclic hetero ring compounds
发明人：KAWAKAMI KATSUHIRO; KANAI KAZUO; HORIUCHI TAKAO; TAKESHITA HIROSHI; KOBAYASHI SYOZO; SUGIMOTO YUICHI; ACHIWA ISSEI; KUROYANAGI JUNICHI
权利人:DAIICHI SANKYO CO LTD
摘要:A 1,6-β-glucan synthetase inhibitor is provided, having potent growth inhibition and having excellent safety. A compound is provided, capable of expressing in a wide spectral range and specifically or selectively, an antifungal effect based on its functional mechanism of 1,6-β-glucan synthesis inhibition. Also provided is a drug, a salt or hydrate thereof, especially an antifungal that contains the compound. Concretely, provided is a compound of the following formula (I), its salt or hydrate, and a drug or antifungal containing, as the active ingredient, the compound, its salt or hydrate: