2-(8-Iodo-5-Methoxy-2-Oxochromen-7-Yloxy)Ethanal置于palladium Diacetate 甲酸,三氟化硼乙醚,四丁基溴化铵,三乙胺体系中,用 氯仿,N,N-二甲基甲酰胺 作为反应溶剂,化学反应 11.5H,反应生成 佛手苷内酯 参考文献:An Efficient Synthesis Of Bergapten 标题:An Efficient Synthesis Of Bergapten 摘要:An Efficient Synthesis Of The Linear Furanocoumarin,Bergapten,Is Reported. In Order To Avoid The Formation Of The Angular Furanocoumarin,We Have Adopted Iodine As Protecting Group At The 8 Position Of The Coumarin Ring. DOI:10.3987/com-05-10451
专利号:US-6734313-B2 优先权日:2000-10-20 标题 :Synthesis of spiro esters, spiro ortho carbonates, and intermediates 发明人:SEEMAYER ROBERT; LIANG JACK 权利人:BIOAVAILABILITY SYSTEMS LLC 摘要:Ortho esters and ortho carbonates can be produced by alkylating esters and carbonates with, for example, the hexafluorophosphate salt of a trialkyl oxonium ion. The spiro species are useful intermediates in the synthesis of complex organic molecules. Synthetic pathways for the production of medically active compounds incorporates spiro ortho esters. Anti-first-pass effect materials are produced in high yield utilizing a synthetic strategy incorporating cyclic ortho ester intermediates.
专利号:US-6613918-B1 优先权日:2000-10-20 标 题 :Synthesis of spiro ortho esters, spiro ortho carbonates, and intermediates 发明人:SEEMAYER ROBERT; LIANG JACK 权利人:BIOAVAILABILITY SYSTEMS LLC 摘要:Ortho esters and ortho carbonates can be produced by alkylating esters and carbonates with, for example, the hexafluorophosphate salt of a trialkyl oxonium ion. The spiro species are useful intermediates in the synthesis of complex organic molecules. Synthetic pathways for the production of medically active compounds incorporates spiro ortho esters. Anti-first-pass effect materials are produced in high yield utilizing a synthetic strategy incorporating cyclic ortho ester intermediates.
专利号:US-4429138-A 优先权日:1977-10-21 标题 :Process for the synthesis of 5-methoxy-psoralen 发明人:GOUPIL JEAN-JACQUES 权利人:GOUPIL JEAN JACQUES 摘要:A pharmaceutical formulation comprising 5-methoxy psoralen, which is useful in the treatment of psoriasis and other skin disorders, is disclosed herein. 5-Methoxy psoralen may be synthesized from phloroglucinol by a five step process which is also disclosed.
专利号:US-2008051323-A1 优先权日:2004-08-21 标 题 :Chloroquine drug compositions and methods for their synthesis 发明人:KOSAK KENNETH M 权利人:KOSAK KENNETH M 摘要:This invention discloses compositions of chloroquine-coupled active agents, including methods for their preparation. The prior art has shown that chloroquines given as free drug in high enough concentration, enhances the release of various agents from cellular endosomes into the cytoplasm. The purpose of these compositions is to provide a controlled amount of chloroquine at the same site where the active agent is delivered, thereby reducing the overall dosage needed. n The compositions comprise a chloroquine substance coupled to an active agent directly or through a variety of pharmaceutical carrier substances. The carrier substances include polysaccharides, synthetic polymers, proteins, micelles and other substances for carrying and releasing the chloroquine compositions in the body for therapeutic effect. The compositions can also include a biocleavable linkage for carrying and releasing active agents for therapeutic or other medical uses. The invention also discloses carrier compositions that are coupled to targeting molecules for targeting the delivery of chloroquine substances and active agents to their site of action.
专利号:US-7772408-B1 优先权日:2002-08-29 标 题 :Substituted 5-alkoxypsoralens as inhibitors of potassium channel activity in lymphocytes and other cells 发明人:VENNEKAMP JULIA; WULFF HEIKE; CHANDY K GEORGE; GRISSMER STEPHAN; HANSEL WOLFRAM 权利人:UNIV CALIFORNIA 摘要:Compositions of matter comprising 5-phenylalkoxypsoralen compounds and their method of synthesis and use. The compounds are useable to treat diseases or disorders in human or veterinary patients, including autoimmune diseases such as multiple sclerosis. The compounds inhibit potassium channels, including the Kv1.3 channel and at least some of the therapeutic effects of such compounds may be due at least in part to potassium channel inhibition.
专利号:US-2004002611-A1 优先权日:2000-10-20 标 题:Synthesis of spiro esters, spiro ortho carbonates, and intermediates
1: Zhang HL, Wu XY, Mi J, Peng YJ, Wang ZG, Liu Y, Wu XL, Gao Y. A new anti-inflammatory alkaloid from roots of Heracleum dissectum. Chem Biodivers. 2017 May 27. doi: 10.1002/cbdv.201700184. [Epub ahead of print] doi: 10.1016/j.intimp.2017.04.026. [Epub ahead of print] doi: 10.1016/j.jep.2017.03.022. Epub 2017 Mar 21. Review. doi: 10.1155/2016/9507246. Epub 2016 Dec 26. 9: Madeiro SA, Borges NH, Souto AL, de Figueiredo PT, Siqueira-Junior JP, Tavares JF. Modulation of the antibiotic activity against multidrug resistant strains of coumarins isolated from Rutaceae species. Microb Pathog. 2017 Mar;104:151-154. doi: 10.1016/j.micpath.2017.01.028. Epub 2017 Jan 19. doi: 10.3892/ol.2016.5317. Epub 2016 Oct 25. 11: Eskandari EG, Doudi M, Abedi S. An in vitro study of antileishmanial effect of Portulaca oleracea extract. J Vector Borne Dis. 2016 Oct-Dec;53(4):362-369. pii: E7. doi: 10.3390/molecules22010007. doi: 10.3892/ijmm.2016.2794. Epub 2016 Nov 2.
合成参考文献
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