CAS: 5446-18-4; (2,4-Dichlorophenyl)Hydrazine Hydrochloride

上下游产品

CAS号554-00-7 2,4-二氯苯胺 | CAS号58791-83-6 5-氨基-4-氰基-1-(2,... | CAS号14657-26-2 (2,4-dichloroan... | CAS号4792-70-5 5,7-二氯-1H-吲哚-2-甲酸乙酯 | CAS号13123-92-7 2.4-二氯苯肼 | CAS号13124-11-3 4-(2,4-二氯苯)-3-氨基硫脲 | CAS号168273-06-1 利莫纳班 | CAS号162758-35-2 里莫那班羧酸 | CAS号158681-13-1 盐酸利莫那班 | CAS号158941-22-1 5-(4-氯苯基)-1-(2,... | CAS号170937-37-8 4-(4-chlorophen...

2,4-二氯苯胺置于盐酸,Sodium Nitrite,Tin(Ll) Chloride体系中,用 水 作为反应溶剂,化学反应 2.0H,以39%的收率获得产物2,4-二氯苯肼盐酸盐
参考文献:作为原卟啉原氧化酶抑制剂的新型1,3,4-Oxadiazol-2(3 H)-Ones的设计,合成和3D-Qsar分析†
标题:作为原卟啉原氧化酶抑制剂的新型1,3,4-Oxadiazol-2(3 H)-Ones的设计,合成和3D-Qsar分析†
摘要:原卟啉原氧化酶(ppo,Ec 1.3.3.4)已被确定为化学除草剂家族中最重要的作用目标之一,这些除草剂具有一些有趣的特征,例如使用率低,对哺乳动物的毒性低以及对环境的影响小. .作为开发新的ppo抑制剂的研究工作的继续,通过在c-4和c-5位上的取代基闭环设计并合成了一些重要的ppo抑制性除草剂恶二argyl的苯并噻唑类似物.的生物测定结果表明,该系列8,9,和10具有非常好的ppo抑制活性ķ我值范围从0.25至18.63微米.最有趣的是9公升,鉴定了2-((5-(5-叔丁基-2-氧代-1,3,4-恶二唑-2(3 H)-基)-6-氟苯并噻唑-2-基)硫烷基)丙酸乙酯作为其最有前途的候选者,是因为它具有较高的ppo抑制作用(k I = 1.42μm)和在37.5 G Ai / Ha的浓度下具有广谱的芽后除草活性.
DOI:10.1021/jf9026298

专利信息

专利号:US-11040938-B2
优先权日:2016-07-27
标 题 :Continuous flow process for the synthesis of phenylhydrazine salts and substituted phenylhydrazine salts
发明人：MA BING; PAN SHUAI
权利人:SHANGHAI HYBRID—CHEM TECH; SHANGHAI HYBRID CHEM TECH
摘要:The present invention provided a continuous flow process for the synthesis of phenylhydrazine salts and substituted phenylhydrazine salts. Diazotization, reduction, acidic hydrolysis and salifying with acids are innovatively integrated together. Using acidic liquids of aniline or substituted aniline, diazotization reagents, reductants and acids as raw materials, phenylhydrazine derivative salts is obtained through the synthesis process, which is a three-step continuous tandem reaction including diazotization, reduction, acidic hydrolysis and salifying. The described synthesis process is a kind of integrated solutions, which is carried out in an integrated reactor. The feed inlets of the integrated reactor are continuously filled with raw materials. In the integrated reactor, diazotization, reduction, acidic hydrolysis and salifying are carried out continuously and orderly, and phenylhydrazine salts or substituted phenylhydrazine salts is obtained in the outlet of the integrated reactor without interruption. The total reaction time is no more than 20 min.

专利号:US-11939325-B2
优先权日:2020-07-27
标 题 :Process for making biologically active compounds and intermediates thereof
发明人：MAKRIYANNIS ALEXANDROS; VEMURI KIRAN
权利人:MAKSCIENTIFIC LLC
摘要:A process of manufacturing biologically active compounds, their analogs, pharmaceutically acceptable salts, solvates, polymorphs, isotopic variants, and intermediates thereof. Notably, the compounds of the formula IA, 1B, 1C. 1D. 1E, 1F and IG for which novel processes have been disclosed, selectively act on the cannabinoid receptors, and with high affinity. The processes for the preparation of the compounds enable the syntheses of cannabinoid modulators on a large-scale that are eco-friendly and economically viable. Additionally, the processes disclosed enable the synthesis of cannabinoid modulators with high purity and in high yield for their use in making drug substance and drug products.

专利号:US-6132953-A
优先权日:1996-07-02
标 题 :Combinatorial synthesis on soluble polyvalent supports having a discrete architecture
发明人：CHAPMAN KEVIN T; HUTCHINS STEVEN M; KIM RONALD M; MANNA MAHUA
权利人:MERCK & CO INC
摘要:The present invention is directed to the use of a soluble polyvalent support for the preparation of combinatorial libraries of compounds. The resultant combinatorial libraries are useful in screening for biologically active moieties in the drug discovery process or in developing compounds with desired physical and chemical properties.

专利号:US-8461184-B2
优先权日:2006-05-31
标题 :Sulphur containing pyrazole derivatives as selective cannabinoid CB1 receptor antagonists
发明人：LANGE JOSEPHUS H M; KRUSE CORNELIS G; VLIET VAN BERNARD J
权利人:LANGE JOSEPHUS H M; KRUSE CORNELIS G; VLIET VAN BERNARD J; SOLVAY PHARM BV
摘要:The present invention relates to sulphur containing pyrazole derivatives, and their S-oxidized active metabolites, as selective cannabinoid CB 1 receptor antagonists having a high CB 1 /CB 2 receptor subtype selectivity, to methods for the preparation of these compounds, to novel intermediates useful for the synthesis of these pyrazole derivatives, to pharmaceutical compositions comprising one or more of these pyrazole derivatives as active ingredients, as well as to the use of these pharmaceutical compositions for the treatment of psychiatric and neurological disorders. The compounds have the general formula (I) n nwherein the symbols have the meanings given in the specification.

专利号:US-8044203-B2
优先权日:2002-05-10
标 题 :Chiral indole intermediates and their fluorescent cyanine dyes containing functional groups
发明人：MUJUMDAR RATNAKER B; WEST RICHARD MARTIN
权利人:UNIV CARNEGIE MELLON; GE HEALTHCARE UK LTD
摘要:This invention relates to the functionalized cyanine dyes and more particularly, to the synthesis of chiral 3-substituted 2,3′-dimethyl-3H-indole and its derivatives as intermediates for preparation of cyanine dyes, to methods of preparing these dyes and the dyes so prepared.

专利号:US-2019152896-A1
优先权日:2016-07-27
标题 :Continuous Flow Process For the Synthesis of Phenylhydrazine Salts and Substituted Phenylhydrazine Salts