1-甲基-4-[1-(4-甲基苯基)乙基]苯置于氢气,镍体系中,400.0 °C,1.96 Mpa 条件下,反应生成 4-乙基甲苯 参考文献:Production Of Aromatic Hydrocarbons From Diarylalkanes 标题:Production Of Aromatic Hydrocarbons From Diarylalkanes
专利号:US-2003162992-A1 优先权日:2001-12-14 标 题 :Preparation of intermediates useful in the synthesis of antiviral nucleosides 发明人:WATANABE KYOICHI A; DU JINFA 摘要:The present invention is an efficient process for the manufacture of α-acyloxyacetaldehyde, a key intermediate in the synthesis of 1,3-oxathiolane and 1,3-dioxolane nucleosides.
专利号:US-5475177-A 优先权日:1989-05-26 标 题:Process for the synthesis of alkylated aromatic hydrocarbons 发明人:GANHY JEAN-PIERRE 权利人:SOLVAY INTEROX 摘要:PCT No. PCT/EP92/02026 Sec. 371 Date May 19, 1994 Sec. 102(e) Date May 19, 1994 PCT Filed Sep. 2, 1992 PCT Pub. No. WO93/05001 PCT Pub. Date Mar. 18, 1993.Process for the synthesis of alkylated aromatic hydrocarbons containing a saturated alkyl chain comprising at least four carbon atoms, according to which an aromatic hydrocarbon substituted by a saturated short-chain alkyl group comprising one to three carbon atoms is reacted with an olefin in the presence of a catalyst which comprises at least one alkali metal or one alkali metal hydride impregnated on an alumina support and the catalyst is prepared in the reaction medium in the presence of the aromatic hydrocarbon containing a short alkyl chain by mixing anhydrous alumina with the alkali metal hydride or with the alkali metal, the ratio by weight of the alkali metal or of the alkali metal hydride to the alumina support being between 0.6 and 1.8. Use of the process for the synthesis of tert-amylbenzene by alkylation of cumene with ethylene.
专利号:US-5288936-A 优先权日:1989-05-26 标题 :Process for the synthesis of alkylated aromatic hydrocarbons 发明人:GANHY JEAN-PIERRE; JACOBS PIERRE; BAES MARLEEN; MARTENS JOHAN 权利人:INTEROX SA 摘要:PCT No. PCT/BE90/00022 Sec. 371 Date Jan. 24, 1992 Sec. 102(e) Date Jan. 24, 1992 PCT Filed May 25, 1990 PCT Pub. No. WO90/14323 PCT Pub. Date Nov. 29, 1990.Process for the synthesis of aromatic alkylated hydrocarbons with a saturated alkyl chain including at least four carbon atoms, according to which an aromatic hydrocarbon, replaced by an alkyl group with a short saturated chain comprising one to three carbon atoms, is made to react with an olefin in the presence of a catalyst made up of at least one alkaline metal or a alkaline metal hydride impregnated on an alumina support. The process is characterised by the fact that the catalyst is prepared in the reaction medium in the presence of the aromatic hydrocarbon with a short alkyl chain by mixing anhydrous alumina with the alkaline metal hydride or with the alkaline metal, and then the olefin is introduced in order to start the reaction.
专利号:US-4565896-A 优先权日:1984-10-22 标 题 :Process for low pressure synthesis of ethylene glycol from synthesis gas 发明人:KNIFTON JOHN F; DURANLEAU ROGER G 权利人:TEXACO INC 摘要:This invention relates to the manufacture of ethylene glcyol and more particularly to a low pressure process for making ethylene glycol comprising reacting synthesis gas, i.e. a mixture of carbon monoxide and hydrogen, plus formaldehyde in the presence of a homogeneous liquid catalyst containing an effective amount of cobalt-containing compound and a silicon or germanium-containing promoter and a solvent at a temperature of at least 50 DEG C. and a pressure of at least 500 psi wherein said ethylene glycol product separates as a separate liquid phase from the solvent.
专利号:US-6245937-B1 优先权日:1996-11-29 标题 :Liquid phase parallel synthesis of chemical libraries 发明人:CHENG SOAN; SAUNDERS JOHN 权利人:DUPONT PHARMACEUTICALS RES LAB 摘要:This invention features methods of biphasic synthesis for synthesizing combinatorial libraries and combinatorial libraries of chemical compounds utilizing the template, and combinatorial libraries of chemical compounds formed by the methods of this invention.
专利号:US-8664402-B2 优先权日:2011-03-09 标题:Process for preparing 1-(6-methylpyridin-3-yl)-2-[4-(methylsulfonyl)phenyl]ethanone, an intermediate of etoricoxib 发明人:CASTELLIN ANDREA; STABILE PAOLO; FONTANA FRANCESCO; DE LUCCHI OTTORINO; CAPORALE ANDREA; TARTAGGIA STEFANO 权利人:CASTELLIN ANDREA; STABILE PAOLO; FONTANA FRANCESCO; DE LUCCHI OTTORINO; CAPORALE ANDREA; TARTAGGIA STEFANO; ITALIANA SINT SPA 摘要:A process for preparing 1-(6-methylpyridin-3-yl)-2-[4-(methyl sulfonyl)phenyl]ethanone, an intermediate of the synthesis of Etoricoxib. The synthesis of the intermediates useful for such preparation is also described.
摘要:Davies, H. M. L.; Morton, D., Science of Synthesis: Stereoselective Synthesis, (2011) 3, 551. 摘要:Driver, T. G., Science of Synthesis: Cross Coupling and Heck-Type Reactions, (2012) 2, 314. 摘要:Hudson, R.; Moores, A., Science of Synthesis: Catalytic Reduction in Organic Synthesis, (2017) 1, 72. 摘要:Chen, P.; Liu, G., Science of Synthesis: Catalytic Oxidation in Organic Synthesis, (2017) 1, 204. 摘要:Parmeggiani, F.; Galman, J. L.; Montgomery, S. L.; Turner, N. J., Science of Synthesis, (2019) , 389.