CAS: 64115-88-4; 1-Bromo-2-(Trifluoromethoxy)Benzene

上下游产品

1-trifluoromethoxybenzene 2-(trifluoromethoxy)phenyllithium 4-bromo-2,2-difluoro-1,3-benzodioxole Benzoyl bromide o-benzyl-α,α,α-trifluoromethoxybenzene 3-bromo-2-(trifluoromethoxy)benzoic acid 3-bromo-6-(trifluoromethoxy)benzoic acid 2-trifluoromethoxyphenylboronic acid

苯甲酰溴置于苯基溴乙炔,四丁基二氟三苯硅酸铵体系中,用 甲苯 作为反应溶剂,化学反应 14.0H,反应生成 邻溴三氟甲氧基苯
参考文献:三氟甲基苯甲酸酯 (Tfbz):多功能三氟甲氧基化试剂
标题:三氟甲基苯甲酸酯 (Tfbz):多功能三氟甲氧基化试剂
摘要:苯甲酸三氟甲酯 (Tfbz) 被开发为一种新的货架稳定的三氟甲氧基化试剂,它可以很容易地从廉价的原料中制备,使用 Kf 作为唯一的氟源.芳烃的三氟甲氧基化-卤化,烷基(伪)卤化物的亲核取代,与芳基锡烷的交叉偶联和烯烃的不对称双官能化证明了 Tfbz 的合成效力.在冠醚络合的钾阳离子的帮助下,芳炔的前所未有的三氟甲氧基化-卤化在室温下顺利进行,这显着稳定了衍生自 Tfbz 的三氟甲氧基阴离子.
DOI:10.1021/jacs.8B04000

专利信息

专利号:US-7884125-B2
优先权日:2008-04-30
标 题:Straightforward entry to 7-azabicyclo[2.2.1]heptane-1-carbonitriles and subsequent synthesis of epibatidine analogues
发明人：STEVENS CHRISTIAN; HEUGEBAERT THOMAS
权利人:UNIV GENT
摘要:The present invention relates to a group of substituted-7-azabicyclo-[2.2.1]heptyl derivatives with biological activity. The present invention also relates to synthetic methods for producing said substituted-7-azabicyclo-[2.2.1]heptyl derivatives. The present invention also relates to certain intermediates for producing such substituted-7-azabicyclo-[2.2.1]heptyl derivatives, as well as a synthetic method for producing such intermediates. The present invention also relates to pharmaceutical compositions comprising such substituted-7-azabicyclo-[2.2.1]heptyl derivatives, as well as their use as medicaments for the treatment of diseases mediated by a Nicotinic Acetylcholine Receptor or a receptor being a member of the Neurotransmitter-gated Ion Channel Superfamily, such as pain, Alzheimer's disease, Parkinson's disease, schizophrenia, epilepsy and nicotine addiction.

专利号:US-4157344-A
优先权日:1978-01-16
标题 :Preparation of aryl trifluoromethyl ethers
发明人：FEIRING ANDREW E
权利人:DU PONT
摘要:A one-step process for the synthesis of aryl trifluoromethyl ethers by reacting phenol or certain substituted phenols with a perhalomethane and hydrogen fluoride is provided. The compounds produced by the process of this invention are useful intermediates in the production of dyestuffs and pharmaceuticals.

专利号:US-4446078-A
优先权日:1982-01-21
标 题 :Process for the preparation of α,α-difluoroalkyl-thiophenyl ketones
发明人：DESBOIS MICHEL
权利人:RHONE POULENC SPEC CHIM
摘要:A process for the preparation of alpha , alpha -difluoroalkoxy or alpha , alpha -difluoroalkylthiophenyl ketones, in which a polyhaloalkoxybenzene or a polyhaloalkylthiobenzene is reacted with a carboxylic acid, a precursor or a derivative of this acid in the presence of boron trifluoride in such an amount that the absolute pressure of the boron trifluoride within the reaction vessel exceeds 1 bar, and in the presence of hydrofluoric acid as a solvent. The resultant products are useful as intermediates in the synthesis of compounds having phytosanitary (e.g., herbicidal) or pharmaceutical activity.

专利号:US-4438043-A
优先权日:1982-04-22
标题:Process for preparation of di- or trifluoromethoxyphenyl ketones or di- or trifluoromethylthiophenyl ketones
发明人：DESBOIS MICHEL
权利人:RHONE POULENC SPEC CHIM
摘要:A process for the preparation of di- or trifluoromethoxyphenyl ketones or di- or trifluoromethylthiophenyl ketones, characterized in that, in a first stage, a di- or trihalomethoxybenzene or a di- or trihalomethylthiobenzene is reacted with a trihalomethylated aromatic or aliphatic compound in the presence of boron trifluoride in an amount such that the absolute pressure of boron trifluoride within the reaction vessel exceeds 1 bar, and in the presence of hydrofluoric acid as a solvent and in that, in a second stage, the product of the first stage is hydrolyzed. The resultant products are useful as intermediates in the synthesis of compounds having a pharmaceutical or phytosanitary (e.g., herbicidal) activity.

专利号:US-4575571-A
优先权日:1983-06-23
标题:Process for the simultaneous halogenation and fluorination of aromatic derivatives
发明人：DESBOIS MICHEL; DISDIER CAMILLE
权利人:RHONE POULENC SPEC CHIM
摘要:A process for the stimulaneous halogenation and fluorination of aromatic derivatives substituted by at least one group containing a halogenoalkyl unit. The aromatic derivative is reacted with the halogen in liquid hydrofluoric acid. The products obtained are useful as intermediates for the synthesis of compounds having a plant-protecting or pharmaceutical activity.

专利号:US-2009275616-A1
优先权日:2008-04-30
标 题 :Straightforward entry to 7-azabicyclo[2.2.1]heptane-1-carbonitriles and subsequent synthesis of epibatidine analogues