专利号:US-9932361-B2 优先权日:2013-02-20 标题:Convenient process for the preparation of statins 发明人:DE LUCCHI OTTORINO; TARTAGGIA STEFANO; FERRARI CLARK; GALVAGNI MARCO; PONTINI MARTA; FOGAL STEFANO; MOTTERLE RICCARDO; MORENO ROSA MARIA; COMELY ALEX 权利人:F I S —FABBRICA ITALIANA SINTETICI S P A 摘要:Object of the present invention is an improved process for the preparation of key intermediates for the synthesis of statins.
专利号:US-9035070-B2 优先权日:2010-07-30 标 题 :Process for the preparation of 1-aryl-pyrazol-3-one intermediates useful in the synthesis of sigma receptors inhibitors 发明人:BARTRA SANMARTI MARTÃ?; BERENGUER MAIMO RAMON; MEDRANO RUPEREZ JORGE; GARCIA GOMEZ JORGE; ARIZA PIQUER JAVIER 权利人:BARTRA SANMARTI MARTÃ?; BERENGUER MAIMO RAMON; MEDRANO RUPEREZ JORGE; GARCIA GOMEZ JORGE; ARIZA PIQUER JAVIER; ESTEVE QUÃ?MICA S A 摘要:The invention relates to a process for preparing 1-aryl-pyrazol-3-one intermediates, tautomers, and salts thereof, to novel intermediates, and to the use of the intermediates in the preparation of sigma receptor inhibitors.
专利号:US-12415831-B2 优先权日:2019-01-07 标 题:HPLC free purification of peptides by the use of new capping and capture reagents 发明人:BERGMANN FRANK; POMPLUN SEBASTIAN JOHANNES 权利人:ROCHE DIAGNOSTICS OPERATIONS INC 摘要:The present disclosure relates to the use of a capping and capture reagent in solid phase peptide synthesis. The present disclosure further relates to a method of solid phase peptide synthesis, wherein a capping and capture reagent according to the present disclosure is used. The present disclosure further relates to a method for purification of a (full-length) synthetic peptide via use of a capping and capture reagent according to the present disclosure. The present disclosure also relates to a kit comprising a capping and capture reagent according to the present disclosure and an amino oxy resin or a hydrazine resin and the use of the kit.
专利号:US-2013184472-A1 优先权日:2010-07-30 标题 :Process for the Preparation of 1-ARYL-PYRAZOL-3-ONE Intermediates Useful in the Synthesis of SIGMA Receptors Inhibitors
专利号:WO-2018192923-A1 优先权日:2017-04-18 标题 :Alpha alkylation of aldehyde with a polycyclic olefin 发明人:QUINTAINE JULIE; MACMILLAN DAVID W C 权利人:FIRMENICH & CIE 摘要:The present invention relates to the field of organic synthesis and more specifically to the alpha alkylation of an aldehyde with a polycyclic olefin followed by a ring opening step in order to provide compound of formula (I) in the form of any one of its stereoisomers or a mixture thereof and wherein R represents a hydrogen atom or C 1-8 linear alkyl group; R 1 , R 2 , R 3 and R 4 represent, when taken separately, independently of each other, a hydrogen atom or a C 1-2 linear alkyl group or a C 3-4 linear or branched alkyl group; or R 2 and R 3 , when taken together, represent a C 4-10 linear, branched or cyclic alkanediyl group and n is 1 or 2.
专利号:CA-2800750-A1 优先权日:2010-07-30 标题 :Process for the preparation of 1-aryl-pyrazol-3-one intermediates useful in the synthesis of sigma receptors inhibitors
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