CAS: 71469-93-7; Methyl 4-Aminopyridine-2-Carboxylate

相似化合物

1291487-29-0 100047-36-7 1159981-86-8

上下游产品

4-Chloro-pyridine-2-carboxylic acid methyl ester 4-chloropicolinic acid 4-azido-pyridine-2-carboxylic acid methyl ester 4-chloro-pyridine-2-carbonyl chloridemethyl 4-[3-(4-(5-phenylpentyloxy)phenyl)propanoylamino]pyridine-2-carboxylate 4-(diphenylmethanesulfonylamino)pyridine-2-carboxylic acid methyl ester 4-benzoylaminopyridine-2-carboxylic acid methyl ester 4-[3-(3-chlorophenyl)propylamino]pyridine-2-carboxylic acid methyl ester

4-氯-吡啶-2-酰氯置于sodium Azide,Palladium 10% On Activated Carbon,氢气体系中,用 甲醇,水,N,N-二甲基甲酰胺 作为反应溶剂,20.0~80.0 °C,400.01 Kpa 条件下,反应 48.5H,反应生成 4-氨基吡啶-2-甲酸甲酯
参考文献:Pyrimidin-4-One Derivatives And Their Use In The Treatment,Amelioration Or Prevention Of A Viral Disease
标题:Pyrimidin-4-One Derivatives And Their Use In The Treatment,Amelioration Or Prevention Of A Viral Disease
摘要:本发明涉及具有通式ii的化合物,可选地以药学上可接受的盐,溶剂合物,多型体,前药,互变异构体,消旋体,对映体或二对映体或其混合物的形式存在,用于治疗,改善或预防病毒性疾病.此外,还披露了特定的联合疗法.

专利信息

专利号:WO-2022256660-A1
优先权日:2021-06-04
标 题:Process for the synthesis of substituted tetrahydrofuran modulators of sodium channels
发明人：HARRISON CRISTIAN
权利人:VERTEX PHARMA
摘要:Provided in this application is a process for making Compound I (I) and pharmaceutically acceptable salts thereof, useful as inhibitors of sodium channels. Processes for making various intermediate products, and suitable salts thereof, are also provided.