CAS: 865-50-9; Trideuterio(Iodo)Methane

上下游产品

CAS号811-98-3 氘代甲醇 | CAS号1849-29-2 甲醇-d3 | CAS号1111-88-2 溴甲烷-d3 | CAS号13669-70-0 奈福泮 | CAS号2122-44-3 trideuteriomethane | CAS号1073232-99-1 N-[2-(S)-甲基-d3-... | CAS号106776-17-4 Trimethylsulfon... | CAS号54840-57-2 甲基-d3-丙二酸二乙酯 | CAS号942047-62-3 Methyl 4-hydrox... | CAS号51219-89-7 四甲脲-d12 | CAS号20786-94-1 dimethyl-1,1,1-... | CAS号2031-95-0 1,1,1-trideuter... | CAS号26351-03-1 咖啡因-D3 | CAS号26351-04-2 咖啡因-D3

氘代甲醇置于磷化氢,碘体系中,用 水 作为反应溶剂,以85%的收率获得产物氘代碘甲烷
参考文献:Synthesis Of Stable Isotope Labeled D9-Mabuterol,D9-Bambuterol,And D9-Cimbuterol
标题:Synthesis Of Stable Isotope Labeled D9-Mabuterol,D9-Bambuterol,And D9-Cimbuterol
摘要:描述了三条稳定且简单的合成路线,用于标记的d9-Mabuterol,D9-Bambuterol和d9-Cimbuterol,分别具有98.5%,99.7%和98.4%的同位素丰度及非常好的纯度.这些结构和同位素丰度通过1H NMR和液相色谱-串联质谱进行了确认.
DOI:10.1002/jlcr.3446

专利信息

专利号:US-2008125587-A1
优先权日:2006-05-25
标 题 :Synthesis of triazole compounds that modulate HSP90 activity
发明人：CHIMMANAMADA DINESH U; LEE CHI-WAN; JAMES DAVID; ZHANG SHIJIE; YING WEIWEN; CHAE JUNGHYUN; PRZEWLOKA TERESA
权利人:CHIMMANAMADA DINESH U; LEE CHI-WAN; JAMES DAVID; ZHANG SHIJIE; YING WEIWEN; CHAE JUNGHYUN; PRZEWLOKA TERESA
摘要:The present invention provides novel methods of preparing triazole compounds which inhibit the activity of Hsp90. One embodiment of the invention is directed to methods for preparing a triazole compound represented by the following Structural Formula: n n n n n n n n n n or a tautomer, a pharmaceutically acceptable salt, solvate, or clathrate, or a prodrug thereof, comprising the steps of: a) reacting an amide represented by the following Structural Formula: n n n n n n n n n n with a thionation reagent to form a thioamide; b) reacting the thioamide of step a) with hydrazine to form a hydrazonamide; c) reacting the hydrazonamide of step b) with a carbonylation or a thiocarbonylation reagent. n In one embodiment, the present invention is a method of synthesis of a compound of formula (IA) n n n n n n n n n n or a tautomer, a pharmaceutically acceptable salt, solvate, or clathrate, or a prodrug thereof, comprising reacting a compound of formula (IIA) n n n n n n n n n n with an oxidizing agent, thereby producing a compound of formula (IA). n The present invention is also directed to a method of preparing a compound or a tautomer thereof represented by the following Structural Formula: n n n n n n n n n n or a tautomer, a pharmaceutically acceptable salt, solvate, or clathrate, or a prodrug thereof. The method comprises the step of reacting a first starting compound represented by the following Structural Formula: n n n n n n n n n n in the presence of a mercuric salt, with a second starting compound represented by the following Structural Formula:

专利号:WO-2023227996-A1
优先权日:2022-05-24
标题 :A deuterated amine compounds and process for synthesis thereof
发明人：AMBATI VIJAY; KOTHARI MANISH; JONNALAGADDA NAGASIVARAO; ALETI RANJITH; KANDASAMY DR SAKHTIVEL; ROHIT CHITTALURI KRISHNA; REDDY KATUKURI MALLIKHARJUNA
权利人:CLEARSYNTH LABS LTD
摘要:The present invention relates to a process for synthesis of a deuterated compound. Most particularly, it relates to synthesis of a deuterated amine compounds of formula (l) and salts thereof. The said compound is an important key intermediate in the synthesis of deuterated drugs and/or chemical compounds.

专利号:US-7329760-B2
优先权日:2002-04-05
标题 :CC-1065 analog synthesis
发明人：ZHAO ROBERT YONGXIN; CHARI RAVI V J
权利人:IMMUNOGEN INC
摘要:Improved synthesis of seco(−)CBI (5-hydroxy-3-amino-1-[S]-(chloromethyl)-1,2-dihydro-3H-benz(e)indole): n nand improved syntheses therefrom of a wide variety of CC-1065 analogs that comprise a cyclopropabenzidole (CBI) alkylating moiety, and which are collectively DC1 and its derivatives, for the synthesis of cell-targeted therapeutic agents.

专利号:US-7662993-B2
优先权日:2005-11-04
标 题:Synthesis of [13C] and [2H] substituted methacrylic acid, [13C] and [2H] substituted methyl methacrylate and/or related compounds
发明人：ALVAREZ MARC A; MARTINEZ RODOLFO A; UNKEFER CLIFFORD J
权利人:LOS ALAMOS NAT SECURITY LLC
摘要:The present invention is directed to labeled compounds of the formulae n n n n n n n n n n n n wherein Q is selected from the group consisting of —S(â•?O)—, and —S(â•?O) 2 —, Z is selected from the group consisting of 1-naphthyl, substituted 1-naphthyl, 2-naphthyl, substituted 2-naphthyl, and phenyl groups with the structure n n n n n nwherein R 1 , R 2 , R 3 , R 4 and R 5 are each independently selected from the group consisting of hydrogen, a C 1 -C 4 lower alkyl, a halogen, and an amino group selected from the group consisting of NH 2 , NHR and NRR′ where R and R′ are each independently selected from the group consisting of a C 1 -C 4 lower alkyl, an aryl, and an alkoxy group, and X is selected from the group consisting of hydrogen, a C 1 -C 4 lower alkyl group, and a fully-deuterated C 1 -C 4 lower alkylgroup.

专利号:US-2024309003-A1
优先权日:2021-05-04
标题 :Heterocyclic compounds as triggering receptor expressed on myeloid cells 2 agonists and methods of use
发明人：HOUZE JONATHAN B; BOS MAXENCE; MANCUSO JOHN; FRANZONI IVAN; PANDYA BHAUMIK; KAPLAN ALAN
权利人:VIGIL NEUROSCIENCE INC
摘要:The present disclosure provides compounds of Formula I, useful for the activation of Triggering Receptor Expressed on Myeloid Cells 2 (“TREM2â€?). This disclosure also provides pharmaceutical compositions comprising the compounds, uses of the compounds, and compositions for treatment of, for example, a neurodegenerative disorder. Further, the disclosure provides intermediates useful in the synthesis of compounds of Formula I.

专利号:US-2024010638-A1
优先权日:2020-11-13
标题:Improved synthesis of crac channel inhibitors
发明人：STAUDERMAN KENNETH; DUNN MICHAEL; OLMSTEAD KAY
权利人:CALCIMEDICA INC
摘要:Provided herein is an improved synthetic method for the production of CRAC channel inhibitors. The synthetic method provides a method for producing highly pure CRAC channel inhibitors for clinical testing.