CAS: 88255-01-0; 2-((((Methoxycarbonyl)Amino)((2-Nitro-5-(Propylthio)Phenyl)Amino)Methylene)Amino)Ethane-1-Sulfonic Acid

Ethanesulfonic Acid,2-[[[(Methoxycarbonyl)Amino][[2-Nitro-5-(Propylthio)Phenyl]Amino]Methylene]Amino]-,Monosodium Salt 反应生成 尼妥必敏
参考文献:Nafissi-Varchei,M. Mehdi
标题:Nafissi-Varchei,M. Mehdi

专利信息

专利号:US-7893271-B2
优先权日:2005-07-28
标 题 :Benzimidazole carbamates and (thio) carbamates, and the synthesis and use thereof
发明人：CHASSAING CHRISTOPHE PIERRE ALAIN
权利人:INTERVET INT BV
摘要:This invention relates to benzimidazole carbamates and (thio)carbamates corresponding to Formula I: n nHere, X 1 and X 2 are independently O or S, wherein at least one of X 1 and X 2 is O; Y 1 and Y 2 are independently O or S, wherein at least one of Y 1 and Y 2 is O; R 1 is alkyl having from 1-4 carbon atoms; R 2 , R 3 , and R 4 are independently hydrogen or a cation; R 5 and R 6 are independently hydrogen, halogen, alkyl (having from 1-8 carbon atoms), —OR 7 , —SR 8 , —CO—R 9 , —OSO 2 —Ar, or —S(O)R 10 ; R 7 is alkyl having from 1-8 carbon atoms; R 8 is alkyl (having from 1-8 carbon atoms) or aryl; R 9 is alkyl (having from 1-8 carbon atoms), cycloalkyl (having from 3-6 carbon atoms), or aryl; Ar is aryl; and R 10 is alkyl (having from 1-8 carbon atoms) or aryl. The compounds generally are soluble and stable in water, and have antiparasitic (particularly anthelmintic) activity in vivo that is comparable to known water-insoluble benzimidazole carbamates (e.g., albendazole and fenbendazole).

专利号:ES-2344275-T3
优先权日:2005-07-28
标 题 :NEW (UNCLE) CARBAMATES FROM BENZIMIDAZOL WITH ANTIPARASITARY ACTIVITY AND SYNTHESIS OF THEM.

专利号:US-5278181-A
优先权日:1992-05-12
标 题 :Soluble alkyl[5-[amino (phenyl)methyl]-1H-benzimidazol-2-yl] carbamate anthelmintics
发明人：TOWNSEND LEROY B; WISE DEAN S; RAM SIYA
权利人:REGENTS ACTING ON BEHALF OF TH
摘要:Soluble alkyl (5-(amino (phenyl)methyl)-2H-benzimidazol-2-yl)carbamates, their enantiomorphic forms, and acid addition salts thereof are well absorbed and possess curative anthelmintic activity, especially against filarial worms, when administered orally or parenterally. Pharmaceutical compositions containing the compounds and methods of employing the compounds in methods of treating helminth infections in mammals are also disclosed, together with methods of synthesis.

专利号:CN-1191541-A
优先权日:1995-06-14
标题 :Synthesis modification of spinosyn compounds

专利号:PT-1913009-E
优先权日:2005-07-28
标 题 :NEW (TIO) CARBAMATES OF BENZIMIDAZOLE WITH ANTIPARASITARY ACTIVITY AND ITS SYNTHESIS