CAS: 122684-33-7; Methyl 1-Boc-3-Pyrrolidinecarboxylate

相似化合物

441717-40-4 313706-15-9 874964-22-4

上下游产品

CAS号17012-21-4 N-苄基-3-吡咯烷甲酸甲酯 | CAS号24424-99-5 二碳酸二叔丁酯 | CAS号272443-90-0 methyl 6-ethoxy... | CAS号67-56-1 甲醇 | CAS号72925-16-7 |R|-1-B°C-3-羧基吡咯烷 | CAS号98548-90-4 3-吡咯烷甲酸甲酯 | CAS号34619-03-9 碳酸二叔丁酯 | CAS号50893-53-3 1-氯乙基氯甲酸酯 | CAS号18107-18-1 (三甲硅烷)重氮甲烷 | CAS号51535-00-3 1-苄基-5-氧-3-吡咯烷羧酸甲酯 | CAS号313706-15-9 (S)-1-B°C-3-羧基吡咯烷甲酯 | CAS号72925-16-7 |R|-1-B°C-3-羧基吡咯烷 | CAS号140148-70-5 (S)-1-B°C-吡咯烷-3-甲酸 | CAS号411238-88-5 3-(肼基羰基)吡咯烷-1-羧酸叔丁酯 | CAS号114214-69-6 1-B°C-3-羟甲基吡咯烷 | CAS号141699-56-1 1-B°C-3-甲磺酰基氧基甲基吡咯烷 | CAS号122684-34-8 1-B°C-吡咯烷-3-甲酰胺 | CAS号122684-35-9 3-硫代氨基甲酰吡咯烷-1-羧酸叔丁酯 | CAS号186550-13-0 3-氨基吡咯烷-1-羧酸叔丁酯 | CAS号270912-72-6 1-B°C-3-(氨甲基)吡咯烷

1-Boc-3-羟基吡咯烷置于硫酸,Sodium Hydroxide体系中,90.0~210.0 °C,600.01 Kpa 条件下,反应 14.5H,反应生成1-Boc-吡咯烷-3-甲酸甲酯
参考文献:一种1-Boc-3-羟甲基吡咯烷的制备方法
标题:一种1-Boc-3-羟甲基吡咯烷的制备方法
摘要:本发明公开了一种1‑boc‑3‑羟甲基吡咯烷的制备方法,其以环氧氯丙烷为原料,通过还原和关环反应得到3‑羟基吡咯烷,然后经过boc保护反应制得1‑boc‑3‑羟基吡咯烷,然后经过羧基化反应,酯化反应制得,1‑boc‑3‑甲酸甲酯吡咯烷,最后其与氢化铝锂在催化剂的催化下,制备得到1‑boc‑3‑羟甲基吡咯烷,该方法产物合成率高,产物纯度高,原料价廉易得,生产成本低.

专利信息

专利号:US-2025115551-A1
优先权日:2023-10-03
标 题:Synthesis of ras inhibitors
发明人：LI YI; MENDOZA BENJAMIN; NAGANATHAN SRIRAM; WANG ROSS; YI YI; BALLMER STEVEN G; DAVIDSON JAMES; HUANG XIAOJUN
权利人:REVOLUTION MEDICINES INC
摘要:The present invention relates to Ras inhibitors, intermediates in the synthesis thereto, and methods for preparing the Ras inhibitors and the intermediates.

专利号:US-2024390383-A1
优先权日:2021-09-28
标题 :Dioxazines and their use in treatment of gba-related diseases
发明人：NEVE SØREN; BROWN WILLIAM DALBY; THIRSTRUP KENNETH
权利人:ZEVRA DENMARK AS
摘要:The present invention relates to dioxazines, their synthesis, and their use for increasing GBA activity and/or levels as well as treatment of GBA-related diseases, such as Parkinson's disease.

专利号:WO-2025076071-A2
优先权日:2023-10-03
标 题 :Synthesis of ras inhibitors