CAS: 1501-84-4; Rimantadine (Hydrochloride)

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13392-28-4 887336-05-2 1005341-52-5

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CAS号78679-71-7 1-adamantyl met... | CAS号90812-24-1 3-(1-氨基乙基)-1-金刚烷醇盐酸盐 | CAS号128487-73-0 1-[1-[(1-amino-...

1-溴金刚烷置于吡啶,氯化亚砜,Metatartaric Acid,硫酸,Palladium On Activated Charcoal,盐酸羟胺,氢气,Cesium Formate,溶剂黄146体系中,用 四氢呋喃,乙醇,苯 用作溶剂,5.0~100.0 °C,400.01 Kpa 条件下,反应 30.0H,反应生成盐酸金刚乙胺
参考文献:一种抗流感病毒制剂的制备方法
标题:一种抗流感病毒制剂的制备方法
摘要:本发明公开了一种抗流感病毒制剂的制备方法,包括1‑溴金刚烷制备,金刚烷甲酸制备,金刚烷甲酰氯制备,金刚烷甲基酮制备,1‑金刚烷甲基酮肟制备,盐酸金刚乙胺制备,抗流感病毒制剂制备,其中金刚烷甲基酮制备步骤为:在烧瓶中加入三甲基铝,甲酸铈,然后滴加金刚烷甲酰氯的苯溶液,使金刚烷甲酰氯与三甲基铝反应生成金刚烷甲基酮,反应完成后将反应液倒入冰水中,然后过滤,干燥,所得浅黄色的沉淀即为金刚烷甲基酮.有益效果为:本发明的制备方法条件温和,工艺简单可行,产品收率高,所制抗流感病毒制剂可以有效预防和治疗甲型/乙型流感病毒感染,还能有效缓解感冒症状.

专利信息

专利号:EP-1685138-B1
优先权日:2003-11-17
标题 :Regiospecific synthesis of nicotine derivatives
发明人：COMINS DANIEL L; KING LAURA S; DESPAGNET EMILIE
权利人:UNIV NORTH CAROLINA STATE
摘要:Methods of synthesizing nicotine analogs and derivatives are described. The methods are particularly useful for the regioselective production of enantiomerically pure nicotine analogs having substituents at the C4 position. Intermediates useful for the synthesis of such compounds are also described.

专利号:EP-1669379-B1
优先权日:2003-09-23
标 题 :3,5-dimethyl-1-adamantyl-ammonium polymeric salts and the use thereof in the form of antiviral agents
发明人：MARCHUKOV VALERY ALEKSANDROVIC; PLATONOV VITALY GEORGIEVICH; SELKOV SERGEI ALEKSEEVICH; CHERNOBROVY ALEKSANDR NIKOLAEV
权利人:AKCIJU SABIEDRIBA OLAINFARM
摘要:This invention relates to the polymeric salts of 3.5-dimethyl-1-adamantylammonium and carboxylated (co)polymers, as well as to the use of produced salts as antiviral agents. Object of the invention is the synthesis of new salts of 3.5-dimethyl-1-adamantylammonium and carboxylated (co)polymers, identification of the compounds with antiviral activity and durable action among them. The task is solved by the synthesis of salts of 3.5-dimethyl-1-adamantylammonium and water-soluble carboxylated (co)polymers of a general formula (1): nwhere m and n are mol%, m = 100 - n, nand carboxylated (co)polymers are selected from the group: nvinylaminosuccinic acid, a copolymer of vinyl alcohol and N-vinylaminosuccinic acid, a copolymer of N-vinylpyrrolidone and N-vinylaminosuccinic acid, copolymer of N-vinylpyrrolidone and crotonic acid; copolymer of N-vinylaminosuccinimide and maleic anhydride; copolymer of N-vinylpyrrolidone and maleic anhydride; polyacrylic acid A general synthesis method and synthesis examples are given for each of claimed compounds, as well as the results of identification of toxicity and comparative antiviral activity. Produced compounds are expressly identified by methods of IR analysis, elements analysis, and potentiometric titration, have quite high antiviral activity against the viruses of influenza types A and B, at that they feature durable (prolonged) action which allows using these produced salts not only as antiviral medications for sparing treatment but for prevention of viral diseases.

专利号:US-2007167530-A1
优先权日:2003-12-23
标 题:Method for depletion of sulphur and/or compounds containing sulphur from a biochemically produced organic compound
发明人：GERLACH TILL; MELDER JOHANN-PETER; HOFFER BRAM W; MEIER ANTON
权利人:BASF AG
摘要:Method of reducing the concentration of sulfur and/or a sulfur-containing compound in a biochemically prepared organic compound by bringing the respective organic compound into contact with an adsorbent. Ethanol which has a particular specification and can be prepared by the abovementioned method, and its use as solvent, disinfectant, as component in pharmaceutical or cosmetic products or in foodstuffs or in cleaners, as feed in steam reforming processes for the synthesis of hydrogen or in fuel cells, or as building block in chemical synthesis.

专利号:US-8557979-B2
优先权日:2004-06-10
标题 :Carbapenem antibacterials with gram-negative activity and processes for their preparation
发明人：CHOI WOO-BAEG; KOWALIK EWA
权利人:CHOI WOO-BAEG; KOWALIK EWA; FOB SYNTHESIS INC
摘要:The present invention provides β-methyl carbapenem compounds and pharmaceutical compositions useful in the treatment of bacterial infections and methods for treating such infections using such compounds and/or compositions. The invention includes administering an effective amount of a carbapenem compound or salt and/or prodrug thereof to a host in need of such a treatment. The present invention is also in the field of synthetic organic chemistry and is specifically provides an improved method of synthesis of β-methyl carbapenems which are useful as antibacterial agents.

专利号:US-6869973-B2
优先权日:2000-06-22
标题:Nitrosated and nitrosylated taxanes, compositions and methods of use
发明人：GARVEY DAVID S; LETTS L GORDON; LIN CHIA-EN; RICHARDSON STEWART K; WANG TIANSHENG
权利人:NITROMED INC
摘要:The present invention describes novel nitrosated and/or nitrosylated taxanes, and novel compositions comprising at least one nitrosated and/or nitrosylated taxane, and, optionally, at least one compound that donates, transfers or releases nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor, stimulates endogenous synthesis of nitric oxide or is a substrate for nitric oxide synthase and/or at least one therapeutic agent. The present invention also provides novel compositions comprising at least one taxane and at least one compound that donates, transfers or releases nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor, stimulates endogenous synthesis of nitric oxide or is a substrate for nitric oxide synthase and/or at least one therapeutic agent. The compounds and compositions of the present invention can also be bound to a matrix. The present invention also provides methods for treating or preventing cardiovascular diseases and disorders, autoimmune diseases, pathological conditions resulting from abnormal cell proliferation, polycystic kidney disease, inflammatory disease, preserving organs and/or tissues or to inhibit wound contraction, particularly the prophylactic and/or therapeutic treatment of restenosis, by administering nitrosated and/or nitrosylated taxane or parent taxanes in combination with nitric oxide donors that are capable of releasing nitric oxide or indirectly delivering or transferring nitric oxide to targeted sites under physiological conditions.

专利号:US-2022233673-A1
优先权日:2019-06-04
标 题:METHODS OF PRODUCING SHIGA TOXIN B-SUBUNIT (STxB) MONOMERS AND OLIGOMERS, AND USES THEREOF
发明人：BILLET ANNE; SCHMIDT FRÉDÉRIC; JOHANNES LUDGER; SERVENT DENIS; MOURIER GILLES; TARTOUR ÉRIC; KAY MICHAEL; FULCHER JAMES M
权利人:INST CURIE; CENTRE NAT RECH SCIENT; INST NAT SANTE RECH MED; COMMISSARIAT A LENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES CEA; APHP ASSIST PUBLIQUE HOPITAUX DE PARIS; UNIV PARIS; UNIV OF UTAH RESEARCH FOUDATION; UNIV UTAH RES FOUND
摘要:A method of producing a monomer of a Shiga toxin B-subunit (STxB) protein or of a variant thereof by peptide chemical synthesis, as well as to a method of producing a pentamer of the STxB protein or of the variant thereof. The methods are particularly advantageous as they overcome major issues typically observed in peptide chemical synthesis, including solubility and purity issues.