CAS: 1570-64-5; 4-Chloro-2-Methylphenol

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邻甲酚置于aluminum (III) Chloride,磺酰氯,2,6-二硫代庚烷体系中,化学反应 4.0H,以95%的收率获得4-氯-2-甲基苯酚
参考文献:在具有远程 Sme,Ome 或 Oh 取代基的甲基硫代烷烃存在下区域选择性合成重要的氯酚
标题:在具有远程 Sme,Ome 或 Oh 取代基的甲基硫代烷烃存在下区域选择性合成重要的氯酚
摘要:摘要 各种甲硫醇,甲氧基(甲硫基)烷烃和双(甲硫基)烷烃已被用作室温下各种酚类氯化反应的区域选择性调节剂.该方法涉及在氯化铝或氯化铁作为活化剂的情况下使用略微过量的磺酰氯.发现具有 2 个和 3 个亚甲基作为间隔基的甲硫醇,甲氧基(甲硫基)烷烃和双(甲硫基)烷烃有利于邻甲酚和苯酚的对位选择性氯化.另一方面,发现具有 6 个和 9 个亚甲基的甲硫醇,甲氧基(甲硫基)烷烃和双(甲硫基)烷烃有利于间二甲苯酚和间甲酚的选择性对氯化.使用双(甲硫基)烷烃的密度泛函理论计算表明,根据作为间隔基的亚甲基单元的数量,有两种不同类型的稳定氯化中间体.图形概要
Doi:10.1080/17415993.2018.1493111

专利信息

专利号:US-2004110228-A1
优先权日:2002-04-01
标 题:Combinatorial organic synthesis of unique biologically active compounds
发明人：MCALPINE SHELLI R; TAYLOR RACHEL E; BOLLA MEGAN L; SEGALL ANCA M
摘要:The invention provides a method for making a combinatorial library of cyclic compounds, such as Holliday junction-trapping compounds, comprising the steps of (a) obtaining a plurality of trimers according to the generic structure X 1- X 2- X 3 , wherein X 1 , X 2 and X 3 can be independently any naturally or nonnaturally occurring amino acids or peptidomimetics thereof; (b) optionally coupling a spacer S to the trimer at either end; (c) cyclizing two trimers or trimer-spacer conjugates in a head-to-tail orientation; thereby obtaining a combinatorial library of compounds, wherein the library does not include an unmodifed or naturally occurring Holliday Junction-trapping compounds. The invention additionally provides methods macrocyclic compounds that are synergimycin derivatives.

专利号:US-5132468-A
优先权日:1990-01-19
标题 :C-alkylation of hydroquinone or monoethers thereof
发明人：DOUSSAIN CLAUDE; GUBELMANN MICHEL; TIREL PHILIPPE-JEAN
权利人:RHONE POULENC CHIMIE
摘要:The alkyl hydroquinones, e.g., methyl hydroquinone (a useful intermediate in the preparation of the monomer methyl hydroquinone diacetate, itself used for the synthesis of thermotropic polymers), are prepared by reacting (C-alkylating) hydroquinone or a monoether thereof with a lower alkanal, in the vapor phase, with a catalytically effective amount of at least one solid metal oxide.

专利号:US-4460793-A
优先权日:1980-12-30
标 题:Preparation of monochloromethyl ketones
发明人：JAUTELAT MANFRED; ARLT DIETER; JAEGER GERHARD
权利人:BAYER AG
摘要:A process for the production of a monochloromethyl ketone of the formula in which R1, R2 and R3 each independently is a hydrogen atom or an optionally substituted alkyl, alkenyl, alkinyl or aryl radical, or R1 and R2 together with the carbon atom to which they are attached form an optionally substituted carbocyclic ring, comprising reacting a 1,1-dichloroalkene of the formula with a phenolate of the formula in which R4 each independently is a halogen atom, a nitro group, or an optionally substituted alkyl, alkoxy or aryl radical, n is 0, 1, 2 or 3, and M is one equivalent of an alkali metal ion or alkaline earth metal ion, thereby to obtain a phenyl ether intermediate, and then subjecting the phenyl ether intermediate to an acid hydrolysis. The products are useful as intermediates in the synthesis of fungicides.

专利号:US-4161609-A
优先权日:1977-09-14
标题:Synthesis of carboxylic acid esters
发明人：CRAMER RICHARD D
权利人:DU PONT
摘要:A method is provided for converting a carboxylic acid amide to a carboxylic acid ester by reacting a vaporized mixture of the amide and an aliphatic alcohol or a phenol in the presence of a suitable catalyst at temperatures of from 100 DEG C. to 400 DEG C. The process is especially useful for the conversion of methacrylamide to methyl methacrylate.

专利号:US-6395918-B1
优先权日:1998-04-27
标题 :Conversion of a hydroxy group in certain alcohols into a fluorosulfonate ester or a trifluoromethylsulfonate ester
发明人：LOEWENTHAL HANS JACOB EDGAR; LOEWENTHAL RON BENJAMIN
摘要:The present invention provides a method of converting a hydroxy group in alcohols containing an electron withdrawing group into perfluoroalkane sulfonate and fluorosulfonate esters, which are good leaving groups, with inversion of configuration where the hydroxyl-bearing carbon is chiral. The method consists of converting an alcohol to an O—N,N-dialkylsulfamate ester and reacting it with a perfluoroalkansulfonic or fluorosulfonic acid. The method has applications in the synthesis of pharmaceutical and agrochemical compounds.

专利号:US-12286399-B2
优先权日:2023-01-29
标 题:Synthesis of (R)(+)-2-(4-chloro-2-methyl phenoxy)propanoic acid in high enantiomeric excess
发明人：PATEL-FRAMROZE BOMI
权利人:PATEL FRAMROZE BOMI
摘要:Provided herein is a process to react optical active chloroalkyl acid alkyl ester and substituted phenols in an aromatic solvent in the presence of a catalytic quantity of a quaternary ammonium salt to yield an optically active substituted phenoxy alkyl acid.