CAS: 16188-55-9; 4-(Methylthio)Phenylacetic Acid

相似化合物

38746-92-8 39161-84-7 81227-89-6

上下游产品

4-(Methylthio)acetophenone (4-iodophenyl)acetic acid cuprous methylmercaptide morpholine (4-methylsulfanyl-phenyl)-acetic acid methyl ester ethyl 4-methylthiophenylacetate 2-(4-(methylsulfinyl)phenyl)acetic acid

4-(甲硫基)苯基乙腈置于硫酸,水体系中,化学反应 1.0H,反应生成4-甲硫基苯乙酸
参考文献:Crystal Structure Of [4-(Methylsulfanyl)Phenyl]Acetic Acid
标题:Crystal Structure Of [4-(Methylsulfanyl)Phenyl]Acetic Acid
摘要:标题化合物 C9H10O2S(i)在三linic 空间群 P-1 中结晶,单胞参数 A = 6.2249(3),B = 7.3733(5),C = 19.5708(12),å,α = 86.该分子由一个甲基硫酰基和位于 4 位的苄基乙酸键合而成,在不对称单元中以两个分子结晶.这两个分子中乙酸分子的羧酸基形成了典型的 O-H-O 氢键二聚体,O--O 距离分别为 2.673(2) 和 2.646(2) å,形成 R 2 2 (8) 图集图案,将分子成对地连接到单位晶胞中的反转中心周围.R 2 2 (8) 图集图案的平均平面与单位室内同一二聚体中两个邻近苄基的平均平面之间的二面角分别为 64.1(6)° 和 71.3(4)°.在同一个二聚体中,两个苄基之间的二面角为 45.2(1)°.分子间的 C-H-Cg π-环相互作用对该结构起着微弱的支撑作用,并为单元胞中的分子堆积稳定性提供了支持.与 Mopac Am1 计算结果的比较也证实了上述观点.研究了[4-(甲硫基)苯基]乙酸的晶体结构.C9H10O2S 分子在三菱空间群 P-1 中结晶,不对称单元中有两个分子.这两个分子中乙酸分子的羧酸基团在 R 2 2 (8) 图集图案中形成了典型的 O-H-O 氢键二聚体,将分子成对地连接到单元格中的反转中心周围.研究人员对其几何和堆积参数进行了描述,并将其与 Mopac Am1 计算结果进行了比较.
Doi:10.1007/s10870-009-9599-8

专利信息

专利号:US-4388310-A
优先权日:1982-03-01
标 题:6-Amido-2-S-oxides of substituted 2-organothio-pen-2-em-3-carboxylic acids
发明人：CHRISTENSEN BURTON G; DININNO FRANK P; MUTHARD DAVID A; RATCLIFFE RONALD W
权利人:MERCK & CO INC
摘要:Disclosed are 6-amido-2-S-oxides of substituted 2-organothio-pen-2-em-3-carboxylic acids (I) which are useful as antibiotics and as intermediates in the synthesis of substituted pen-2-em-3-carboxylic acids: I wherein: R1 is H or acyl; R2 is hydrogen or methoxyl; R3 is alkyl having from 1-6 carbon atoms; phenylalkyl having 7-12 carbon atoms; and cycloalkyl having 3-6 carbon atoms; and R4 is hydrogen, a removable protecting group or a pharmaceutically acceptable salt or ester moiety.

专利号:US-6531470-B1
优先权日:1998-01-23
标题:Oxazolidinone combinatorial libraries, compositions and methods of preparation
发明人：GORDEEV MIKHAIL F; LUEHR GARY W; PATEL DINESH V; NI ZHI-JIE; GORDON ERIC
权利人:UPJOHN CO
摘要:Oxazolidinones and methods for their synthesis are provided. Also provided are combinatorial libraries comprising oxazolidinones, and methods to prepare the libraries. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising the oxazolidinones. The methods of library preparation include the attachment of oxazolidinones to a solid support. The methods of compound preparation in one embodiment involve the reaction of an iminophosphorane with a carbonyl containing polymeric support.

专利号:US-6111110-A
优先权日:1996-10-30
标 题 :Synthesis of benzo[f]quinolinones
发明人：BRENNAN JOHN; DOECKE CHRISTOPHER WILLIAM; HEATH PERRY CLARK; PATTERSON LAWRENCE EDWARD; UDODONG UKO EFFIONG; WEIGEL LELAND OTTO
权利人:LILLY CO ELI
摘要:A process for preparing intermediates and benzoquinolin-3-one pharmaceuticals, such pharmaceuticals are effective in treating conditions consequent on 5α-reductase.

专利号:US-4086423-A
优先权日:1973-10-12
标题 :Process for cephem synthesis
发明人：FIRESTONE RAYMOND A; RATCLIFFE RONALD W; CHRISTENSEN BURTON G
权利人:MERCK & CO INC
摘要:Cephalosporin antibiotics of the formula: ##STR1## are produced by cycloaddition of a glycine derivative of the formula ##STR2## with a thiazine derivative of the formula ##STR3##

专利号:US-6562844-B2
优先权日:1998-01-23
标 题:Oxazolidinone combinatorial libraries, compositions and methods of preparation
发明人：GORDEEV MIKHAIL F; LUEHR GARY W; PATEL DINESH V; NI ZHI-JIE; GORDON ERIC
权利人:UPJOHN CO
摘要:Oxazolidinones and methods for their synthesis are provided. Also provided are combinatorial libraries comprising oxazolidinones, and methods to prepare the libraries. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising the oxazolidinones. The methods of library preparation include the attachment of oxazolidinones to a solid support. The methods of compound preparation in one embodiment involve the reaction of an iminophosphorane with a carbonyl containing polymeric support.

专利号:CA-2270433-A1
优先权日:1996-10-30
标题:Synthesis of benzo¬f; quinolinones