过氧化氢酶置于钯 水,Pyridine Sulfone,Alumina体系中,用 甲苯 用作溶剂,50.0~110.0 °C,33.33 Mpa 条件下,反应 1.0H,反应生成对环己酮甲酸乙酯 参考文献:Process For The Preparation Of Cyclohexanones 标题:Process For The Preparation Of Cyclohexanones 摘要:本发明涉及一种从相应的苯酚经过部分氢化制备环己酮的方法,其特征在于在隔离环己酮之前,通过使用磺化剂处理通过氢化得到的反应混合物.
专利号:US-4866175-A 优先权日:1966-11-08 标 题 :Novel process for the synthesis of quinoxaline and benzimidazole-N-oxides 发明人:ISSIDORIDES COSTAS H; HADDADIN MAKHLUF J 权利人:RESEARCH CORP 摘要:The synthesis of quinoxaline and benzimidazole-N-oxides and of ester amd amide derivatives of 3-hydroxy-2-quinoxalinecarboxylic acid by a movel process consisting of the reaction between a benzofuroxan and an activated methylene-containing compound under basic conditions.
专利号:WO-2020240266-A1 优先权日:2019-05-31 标题:New endoperoxide compounds, process for obtaining them and uses thereof for control of perkinsiosis in bivalves 发明人:CRISTIANO MARIA; CABRAL LÃ?LIA; LEITE RICARDO; LEAL JOSÉ 权利人:CCMAR CENTRO DE CIENCIAS DO MAR UNIV DO ALGARVE; INST GULBENKIAN DE CIENCIA 摘要:The present invention relates to new endoperoxide compounds and compositions, and to a process for producing them for prophylaxis and control of perkinsiosis in bivalves. Endoperoxide compounds with biological activity against Perkinsus olseni include 13 trioxolanes and 9 tetraoxanes. Protozoan parasites of the genus Perkinsus are known to infect several species of marine molluscs worldwide, like oysters, abalones, clams, scallops, pearl oysters, cockles or mussels. The present invention also describes the synthesis of these compounds, in particular of new endoperoxide compounds of the tetraoxane family. Compositions comprising endoperoxide compounds are useful for prophylaxis and control of perkinsiosis in bivalves. Therefore, the present invention also relates to a method of controlling perkinsiosis in bivalves. The present invention is in the domain of aquaculture, medicine, pharmaceuticals and biochemistry.
专利号:WO-2018175954-A1 优先权日:2017-03-23 标 题 :Synthesis of imidazo[5,1-a]isoindole derivative useful as ido inhibitors 发明人:ANGELAUD REMY; BACHMANN STEPHAN; BEYELER ANDREAS; CARRERA DIANE; FISCHER ROLF; GUILLEMONT-PLASS MAUD; HOU HAIYUN; IDING HANS; KRAFT ANNE KATRIN; MANNS ANDREAS; MEIER ROLAND; NIEDERMANN KARIN; OLBRICH MARTIN; PIECHOWICZ KATARZYNA; REGE PANKAJ; REMARCHUK TRAVIS; SIROIS LAUREN; ST-JEAN FREDERIC; XU JIE 权利人:HOFFMANN LA ROCHE; HOFFMANN LA ROCHE; GENENTECH INC 摘要:Presently provided is a method of making a compound of the Formula (I) wherein X is halogen, which is useful for modulating the activity of indoleamine 2,3-dioxygenase (IDO) and treating diseases and conditions in which the inhibition of IDO mediated immunosuppression is beneficial.
专利号:US-5648484-A 优先权日:1995-03-07 标 题 :Catalytic enantioselective synthesis of a spriofused azetidinone 发明人:WU GUANG-ZHONG 权利人:SCHERING CORP 摘要:A process for producing a compound of the formula ##STR1## comprises the following sequence of steps: ##STR2## wherein the various radicals are as defined in the specification.
专利号:US-8772301-B2 优先权日:2009-12-18 标题 :Compounds for treating disorders mediated by metabotropic glutamate receptor 5, and methods of use thereof 发明人:HARDY LARRY WENDELL; HEFFERNAN MICHELE L R; WU FRANK XINHE; SPEAR KERRY L; SARASWAT LAKSHMI D 权利人:HARDY LARRY WENDELL; HEFFERNAN MICHELE L R; WU FRANK XINHE; SPEAR KERRY L; SARASWAT LAKSHMI D; SUNOVION PHARMACEUTICALS INC 摘要:Provided herein are compounds and methods of synthesis thereof. The compounds set forth herein are useful for the treatment, prevention, and/or management of various disorders, such as neurological disorders, neurodegenerative disorders, neuropsychiatric disorders, disorders of cognition, learning or memory, gastrointestinal disorders, lower urinary tract disorder, and cancer. Compounds set forth herein modulate the activity of metabotropic glutamate receptor 5 (mGluR5) in the central nervous system or the periphery. Pharmaceutical formulations containing the compounds and their methods of use are also provided herein.
专利号:US-2005209477-A1 优先权日:2002-06-20 标题 :Process for producing vinyl perfluoroalkanesulfonate derivative 发明人:KATO SACHIKO; CHUJO IWAO; SUZUKI KOJI 权利人:KATO SACHIKO; CHUJO IWAO; SUZUKI KOJI 摘要:(wherein R 1 , R 2 , R 3 , R 4 and R 5 may be the same or different and each represents a hydrogen atom, substituted or unsubstituted lower alkyl, substituted or unsubstituted lower alkoxy, or the like; R 17 represents trifluoromethyl or the like; R 18 , R 19 , R 20 , R 21 and R 22 may be the same or different and each represents a hydrogen atom, substituted or unsubstituted lower alkyl, or the like). nAn easy and simple process for producing a vinyl perfluoroalkanesulfonate derivative represented by general formula (IV) which is a useful intermediate in synthesis of medicines, natural products, or the like, at a low cost, is provided. The process is characterized by, for example, reacting a carbonyl compound represented by general formula (I) described above with a perfluoroalkanesulfonic anhydride represented by general formula (II) described above in the presence of a pyridine derivative represented by general formula (III) described above in an amount of 0.1 to 1.0 equivalent to the perfluoroalkanesulfonic anhydride.
参考标题:Organocatalyzed Kabbe Condensation Reaction For Mild And Expeditious Synthesis Of 2,2‐dialkyl And 2‐spiro‐4‐chromanones 作者:Naval P. Kapuriya,Jasmin J. Bhalodia,Mrunal A. Ambasana,Rashmi B. Patel,Atul H. Bapodra 摘要:An Expeditious Kabbe Condensation Reaction For The Synthesis Of 2,2‐dialkyl And 2‐spiro‐chroman‐4(1H)‐ones Has Been Developed Using Pyrrolidine‐butanoic Acid In Dmso As Bifunctional Organocatalyst. Unlike Existing Methods, This Reaction Proceeds At Room Temperature With High Yields, Rendering It An Attractive Method To Synthesize A Vast Variety Of Privileged 4‐chromones.
合成参考文献
摘要:Vil’, V. A.; Bityukov, O. V.; Terent’ev, A. O., Science of Synthesis Knowledge Updates, (2019) 3, 397. 摘要:Vil’, V. A.; Bityukov, O. V.; Terent’ev, A. O., Science of Synthesis Knowledge Updates, (2019) 3, 399. 摘要:Li, H.; Wang, Y.; Liu, Q., Science of Synthesis: Base-Metal Catalysis, (2023) 2, 511. 摘要:Li, X.; Song, Q., Science of Synthesis: Cross-Dehydrogenative Coupling, (2023) nan, 351.