CAS: 2013-12-9; D(-)-Norvaline

上下游产品

CAS号338-69-2 D-丙氨酸 | CAS号1821-02-9 2-氧代戊酸 | CAS号105816-58-8 (R)-2-phthalimi... | CAS号760-78-1 DL-正缬氨酸 | CAS号108341-16-8 L-norvaline ben... | CAS号42918-89-8 (R)-2-(((苄氧基)羰基... | CAS号1999-38-8 2-[(2-aminoacet... | CAS号6893-26-1 D-谷氨酸 | CAS号1821-02-9 2-氧代戊酸 | CAS号80696-30-6 D-戊氨醇 | CAS号57521-85-4 B°C-D-正缬氨酸 | CAS号123731-68-0 (S)-1,2-环氧基戊烷 | CAS号62421-33-4 1-(4-methylphen...

L-正缬氨酸置于l-Amino Acid Deaminase From Proteus Mirabilis,Burkholderia Stabilis Formate Dehydrogenase,Meso-Diaminopimelate Dehydrogenase From Symbiobacterium Thermophilum Mutant H227V,Sodium Formate,氯化铵,还原型辅酶ii(Nadph)四钠盐体系中,用 Aq. Phosphate Buffer 用作溶剂,化学反应生成D-正缬氨酸
参考文献:通过一锅生物催化立体转化级联从容易获得的 L-氨基酸中高选择性合成 D-氨基酸†
标题:通过一锅生物催化立体转化级联从容易获得的 L-氨基酸中高选择性合成 D-氨基酸†
摘要:D-氨基酸是重要药物合成所需的关键中间体.然而,建立一种通用的酶促方法,用于从廉价且易于获得的前体和很少的副产物中普遍合成d-氨基酸是具有挑战性的.在这项研究中,我们构建并优化了一条涉及l-氨基酸脱氨酶和d-氨基酸脱氢酶的级联酶催化途径,用于将l-氨基酸生物催化立体转化为d-氨基酸.使用l-苯丙氨酸 ( L-Phe) 作为模型底物,这种人工生物催化级联立体反转路线首先将l-Phe 到苯丙酮酸 (Ppa) 通过涉及表达奇异变形杆菌(Pmlaad) 的l-氨基酸脱氨酶的重组大肠杆菌细胞的催化作用,然后用嗜热共生菌(Stdapdh )的重组内消旋二氨基庚二酸脱氢酶进行立体选择性还原胺化以产生d-苯丙氨酸(d-Phe).通过加入基于甲酸脱氢酶的 Nadph 循环系统,D-Phe 以定量产率获得,对映体过量大于 99%.此外,级联反应体系还用于立体转化多种芳香族和脂肪族l通过将 Pmlaad
Doi:10.1039/c9Ra06301C

专利信息

专利号:US-11247977-B2
优先权日:2018-06-22
标题 :Compound and use thereof in synthesis of brivaracetam intermediate and crude drug
发明人：FENG YAN; WANG RUYONG; YE YIZHANG; ZHANG FENGSEN; GONG XUAN; WANG ZHONGHONG; KANG XINSHAN
权利人:FUJIAN HAIXI PHARMACEUTICALS CO LTD
摘要:The present application provides a compound in formula III, and further provides a use of the compound in the synthesis of a Brivaracetam intermediate and a crude drug, and a synthesis method. A raw material involved in the method of the present application is low in costs and easily available; (R)-4-propyl-dihydrofuran-2-ketone having high optical purity can be prepared; complicated separation and purification steps are avoided; costs are reduced, and the method is more applicable to industrial production.

专利号:US-5350851-A
优先权日:1992-03-16
标题 :Intermediates and a process for synthesis of tetrahydropteridine C6-stereoisomers, including (6S)-tetrahydrofolate and N5-formyl-(6S)-tetrahydrofolate
发明人：BAILEY STEVEN W; AYLING JUNE E
权利人:UNIV SOUTH ALABAMA
摘要:Intermediates and a process for the synthesis of 6-monosubstituted tetrahydropteridine C6-stereoisomers, including (6S)-tetrahydrofolic acid. The intermediates are shown in their two enantiomeric forms as follows: ##STR1## wherein R 1 and R 2 are the same or different and represent hydrogen, methyl, hydroxy, amino, alkyl or dialkylamino, alkoxy, benzyloxy, or benzylthio; R 3 represents an alkene, alkyne, cycloalkyl, benzyl, alkyl (substituted with hydroxy, acetoxy, benzyloxy, alkoxy, alkylthio, amino, carboxy, oxo, or phosphate), a protected aldehyde, or ##STR2## wherein n=1 or 2, R 4 is hydrogen, formyl, methyl, or propargyl, and ZZ represents an amino acid or amino acid polymer.

专利号:US-2022243244-A1
优先权日:2019-10-10
标 题 :Compositions and methods for in vivo synthesis of unnatural polypeptides
发明人：ROMESBERG FLOYD E; FISCHER EMIL C; HASHIMOTO KOJI; FELDMAN AARON W; DIEN VIVIAN T; ZHANG YORKE
权利人:SCRIPPS RESEARCH INST
摘要:Disclosed herein are compositions, methods, and kits for a cell incorporating unnatural amino acids into an unnatural polypeptide. Also disclosed herein are compositions, methods, and kits for increasing activity and yield of the unnatural polypeptide synthesized by the cell.

专利号:US-2023037284-A9
优先权日:2018-11-30
标题:Combination therapy of peptidomimetic macrocycles
发明人：GUERLAVAIS VINCENT; ANNIS DAVID ALLEN
权利人:AILERON THERAPEUTICS INC
摘要:The present disclosure describes the synthesis of peptidomimetic macrocycles and methods of using peptidomimetic macrocycles to treat a condition. The present disclosure also describes methods of using peptidomimetic macrocycles in combination with at least one additional pharmaceutically-active agent for the treatment of a condition, for example, cancer.

专利号:US-2025084410-A1
优先权日:2015-01-12
标 题:Incorporation of unnatural nucleotides and methods thereof
发明人：PTACIN JEROD; MALYSHEV DENIS A; CAFFARO CAROLINA E
权利人:SYNTHORX INC
摘要:Disclosed herein are methods, compositions and kits for the synthesis of proteins which comprises unnatural amino acids that utilize a mutant tRNA.

专利号:WO-02083606-A1
优先权日:2001-04-17
标 题:A linker system for the synthesis and screening of combinatorial libraries of polyamine derivatives on water compatible supports
发明人：HALL DENNIS G; WANG FAN
权利人:UNIV ALBERTA; HALL DENNIS G; WANG FAN
摘要:The invention is directed to resin-conjugated polyamine combinatorial libraries and methods for making and using them, e.g., methods for screening for polyamine binding molecules in biological samples. The invention provides protected benzophenone-substituted resins, and methods for their synthesis. The invention provides hydroxy-triarylmethane-conjugated resins, and methods for their synthesis. The invention provides chlorotriarylmethane resins, and methods for their synthesis. The invention provides resin-conjugated peptide libraries, and methods for their synthesis.