CAS: 2304-94-1; Carbobenzyloxy-Beta-Alanine

该化合物是氨基酸衍生物,其特点是在氨基氨基-亚麻牛群中存在一种苯氧基碳基(Z)保护组,该组通常是白到白的晶状固体,溶于甲醇和二甲基硫氧化物等有机溶剂,但水中溶解性较小,其分子结构包括一个碳酸碱酸组,一个氨基碳酸组,以及一个以苯基组为特征的侧链,从而促成其疏水性特征.Z组是一个保护性动物,在浸泡物合成中有用,特别是在形成需要选择性保护氨基生物组的浸泡酸结壳方面.N-苯氧碳基-九经常用于生物化学研究和药物应用,包括各种生物活性化合物和聚氨基醚的合成.在特定条件下,其稳定性和再活性使其成为有机合成中有价值的中间体.

结构式图片

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107-95-9 3303-84-2 35737-10-1

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CAS号501-53-1 氯甲酸苄酯 | CAS号107-95-9 β-丙氨酸 | CAS号67865-70-7 1-diazonio-3-(p... | CAS号1138-80-3 N-苄氧羰基甘氨酸 | CAS号18605-26-0 N-Cbz-beta-丙氨酸叔丁酯 | CAS号54755-77-0 Z-β-丙氨酸甲酯 | CAS号100-51-6 苯甲醇 | CAS号3642-91-9 Z-β-Ala-ONp | CAS号108-30-5 丁二酸酐 | CAS号34637-22-4 3-(苄氧羰基氨基)-1-丙醇 | CAS号53844-02-3 N-苄氧羰基-3-溴乙胺 | CAS号18605-26-0 N-Cbz-beta-丙氨酸叔丁酯 | CAS号252919-08-7 N-[(苯基甲氧基)羰基]-N... | CAS号65564-05-8 N-苄氧羰基-3-氨基丙醛 | CAS号77153-05-0 N-cbz-N'-b°C-乙二胺 | CAS号72080-83-2 N-Cbz-1,,2-二氨基乙烷 | CAS号3642-91-9 Z-β-Ala-ONp | CAS号30593-19-2 Glycine,N-[N-[(... | CAS号130312-02-6 1-苄氧羰基-3-吡咯烷酮

合成工艺路线路线简述

    氯甲酸苄酯置于三乙胺,三氟乙酸体系中,化学反应 2.67H,反应生成N-Cbz-Beta-丙氨酸
    参考文献:The Use Of Cellulose (Chromatography Paper) As A Cheap,Versatile And Non-Covalent Support For Organic Molecules During Multi-Step Synthesis
    标题:The Use Of Cellulose (Chromatography Paper) As A Cheap,Versatile And Non-Covalent Support For Organic Molecules During Multi-Step Synthesis
    摘要:纤维素色谱纸提供了一种新颖的非共价支持,用于多维阵列的合成和原位纯化.
    Doi:10.1039/b208083D

    海关参考信息

    专利信息


    专利号:US-7351852-B2
    优先权日:2000-09-05
    标题 :T-butoxycarbonylaminoethylamine for the synthesis of PNA monomer units, amino acid derivatives, intermediates therof, and processes for productions of them
    发明人:IKEDA HISAFUMI; SAITO ISAO; NAKAMURA YUSHIN
    权利人:CREDIA JAPAN CO LTD
    摘要:A process for amino acid derivatives shown by the below general formula (I): n n(wherein R 1 means a hydrogen atom or a straight chain or branched chain alkyl group with 1-5 carbon atoms.) having an object to provide a process of the amino acid derivatives of the formula (I) and their synthetic intermediate, t-butoxycarbonylamino-ethylamine, whereby it requires no tedious procedure and is also good in yield, and its application to a mass production is easy, and to provide novel amino acid derivatives of the formula (IV), their synthetic intermediates, and a process thereof, characterized in that it comprises a step to obtain the amino acid derivatives shown by the general formula (I) by hydrolysis of compounds shown by the below formula (II):n n n(wherein R 1 has the same meaning as described above, and R 2 means a straight chain or branched chain alkyl group with 1-4 carbon atoms.) as well as amino acid derivatives shown by the general formula (IV):n n n(wherein R 1 means a hydrogen atom or a straight chain or branched chain alkyl group with 1-5 carbon atoms, and n means any one of integers 1-11.), and a process for the amino acid derivative, characterized in that it comprises a reduction step of benzyloxycarbonyl-ω-amino acid derivatives.

    专利号:US-7417035-B2
    优先权日:1998-11-19
    标 题:Phospholipid derivatives of non-steroidal anti-inflammatory drugs
    发明人:KOZAK ALEXANDER; SHAPIRO ISRAEL
    权利人:DPHARM LTD
    摘要:Disclosed are compounds having non-steroidal anti-inflammatory drugs (NSAIDS) covalently linked to a phospholipid moiety via a bridging group. Also disclosed are a process for the synthesis of the compounds, pharmaceutical compositions comprising the compounds and the use thereof for the treatment of diseases and disorders related to inflammatory conditions.

    专利号:US-6498150-B2
    优先权日:1995-10-17
    标 题 :Low molecular weight cell, bone marrow and immune stimulants
    发明人:TAUB FLOYD; PERUN THOMAS J; MURRAY CHRISTOPHER K; DAUGHENBAUGH RANDALL J; LEDNICER DANIEL
    权利人:DOVETAIL TECHNOLOGIES INC
    摘要:The present invention relates to peptide-like compounds, eg aminocarboxylic acid amide derivatives, and to methods of using same to stimulate cells of the immune system, bone marrow and other organs. The present compounds can be used to enhance vaccination, increase synthesis of and enhance function of blood cell components and enhance anti-neoplastic effects of various agents. The compounds of the invention can be used to produce a variety of further pharmacologic effects.

    专利号:US-2008167491-A1
    优先权日:2000-05-09
    标题:T-butoxycarbonylaminoethylamine for the Synthesis of PNA Monomer Units, Amino Acid Derivatives, Intermediates Thereof, and Processes for Productions of Them

    专利号:US-2005187402-A1
    优先权日:2000-09-05
    标 题 :T-butoxycarbonylaminoethylamine for the synthesis of PNA monomer units, amino acid derivatives, intermediates thereof, and processes for productions of them

    专利号:EP-1318142-B1
    优先权日:2000-09-05
    标题:T-butoxycarbonylaminoethylamine for the synthesis of pna monomer units, amino acid derivatives, intermediates thereof, and processes for productions of them
    上海赛恩斯医药化工有限公司
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    主要参考文献

    [参考文献]: Luckose F, Et Al. Effects Of Amino Acid Derivatives On Physical, Mental, And Physiological Activities. Crit Rev Food Sci Nutr. 2015;55(13):1793-1109.
    [参考文献]: Chu-Biao Xue, Et Al. Asymmetric Synthesis Of Trans-2,3-Piperidinedicarboxylic Acid And Trans-3,4-Piperidinedicarboxylic Acid Derivatives. J Org Chem. 2002 Feb 8;67(3):865-70.
    [参考文献]: Jiansheng Liu, Et Al. Functionalized Nanocarrier Combined Seizure-Specific Vector With P-Glycoprotein Modulation Property For Antiepileptic Drug Delivery. Biomaterials. 2016 Jan:74:64-76.

    合成参考文献


    摘要:Lloyd, C. M.; Dowell, K. F.; Brittain, W. D. G., Science of Synthesis: Modern Strategies in Organofluorine Chemistry, (2025) 2.
    参考文献:10.1007/s00726-012-1443-3
    摘要:Cal M, Jaremko M, Jaremko Ł, Stefanowicz P. One-pot efficient synthesis of N(α)-urethane-protected β- and γ-amino acids. Amino Acids. 2013 Mar;44(3):1085–91.
    参考文献:10.1007/s00213-018-4917-5
    摘要:Jeanblanc J, Bourguet E, Sketriené D, Gonzalez C, Moroy G, Legastelois R, Létévé M, Trussardi-Régnier A, Naassila M. Interest of new alkylsulfonylhydrazide-type compound in the treatment of alcohol use disorders. Psychopharmacology (Berl). 2018 Jun;235(6):1835–44. doi: 10.1007/s00213-018-4917-5.
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