CAS: 4122-68-3; 4-Chlorophenoxyacetyl Chloride

该化合物是一种有机化合物,其特性为功能组,包括乙基氯和苯氧组,其特点是有机化合物,其典型特征是无色的黄色液体,其香味为粉色的黄色液体,该化合物具有活性,特别是由于存在丙基氯的功能组,该化合物在有机合成中成为有用的中间体,特别是在制药和农用化学品生产中;该化合物可发生核分裂性乙酰替代反应,允许其与包括氨和酒精在内的各种核糖类反应,以形成相应的氨化物和酯;此外,乙基氯(4-氯苯氧基)对水体敏感,应谨慎处理,因为它能进行水解,从而产生盐酸和相应的苯丙化合物; 适当的安全防范措施,包括使用个人防护设备,在使用该物质时,由于其腐蚀性性质和潜在健康危害,包括使用个人防护设备,是不可或缺的.

英文名称4-Chlorophenoxyacetyl Chloride
中文名称4-氯苯氧基乙酰氯
IUPAC名称2-(4-chlorophenoxy)acetyl chloride
其它别名Acetylchloride, (4-chlorophenoxy)- (9CI); Acetyl chloride, (p-chlorophenoxy)-(6CI,7CI,8CI); (4-Chlorophenoxy)acetic acid chloride; (4-Chlorophenoxy)acetylchloride; (p-Chlorophenoxy)acetyl chloride; 2-(4-Chlorophenoxy)acetyl chloride
CAS编号4122-68-3
MFCD编号:MFCD00000727
EINECS号:223-923-2
FDA UNII编号:PZT4V53U3L
分子式:C8H6Cl2O2
分子量:205.04
产品CID: 1426468
产品分类化学试剂 → 有机试剂 → 酰卤

相似结构搜索
InChIKey: VRBVHQUSAOKVDH-UHFFFAOYSA-N
InChI=1S/C8H6Cl2O2/c9-6-1-3-7(4-2-6)12-5-8(10)11/h1-4H,5H2…
计算化学: 氢键受体数2.0氢键供体数0.0可旋转键数3.0

物理性质

熔点18.8 °C
沸点142 °C (17 torr)
闪点112.9 °C
密度1.314
PSA:26.3
LogP:2.4842
折射率n20/D 1.5486(文献)
蒸汽压0.00965 mmHg at 25 °C
敏感性易受潮
外观形态无色至淡黄色至浅橙色透明液体
储存条件惰性气氛,室温
产品应用该化合物用于编制:替代乙苯酮衍生物2-(4--氯酚氧乙酰氨基)-3-乙氧碳基[2,3-B]二丙基丙基丁2-(-4-氯芬氧基)-NÄ-[2-(4-4-克氯苯基)乙基]乙酰乙酰二酰胺

MSDS等安全信息

GHS象形图
GHS符号GHS05;
注释: Corrosion
危险类别皮肤腐蚀类别1B
严重眼损伤类别1
金属腐蚀物类别1
皮肤腐蚀类别1C
警示词Danger(危险)
危险描述H314 |造成严重皮肤灼伤和眼损伤.
H318 |造成严重眼损伤.
H290 |可能对金属造成腐蚀.
防范说明P280-P305+P351+P338-P310-P260h-P301+P330+P331-P303+P361+P353-P501a-P234-P260-P264-P301+P330+P331+P310-P303+P361+P353+P310+P363-P304+P340+P310-P305+P351+P338+P310-P390-P405-P406-P501
危险等级8
UN编号UN 3265 8/PG 2
危险品标志C
包装等级II
安全声明23-26-36/37/39-45
危险类别码34
WGK Germany3

欧盟法规

ECHA物质C&L通报REACH预注册

上下游产品

合成工艺路线路线简述

对氯苯氧乙酸置于氯化亚砜体系中,化学反应 3.0H,反应生成 4-氯苯氧基乙酰氯
参考文献:Phenylalanine Derivatives Enhancing Intestinal Absorption Of Insulin In Mice.
标题:Phenylalanine Derivatives Enhancing Intestinal Absorption Of Insulin In Mice.
摘要:研究了n-酰基-L-和d-苯丙氨酸衍生物对正常小鼠胰岛素肠道吸收的辅助效应.根据小鼠口服胰岛素和辅料联合给药后的血糖浓度和胰岛素水平,推测了n-酰基部分的化学结构性质与促吸收活性之间的相关性.n-酰基-苯丙氨酸衍生物对胰岛素肠道吸收具有辅效应的化学结构性质如下:1. 芳环存在,与酰基羰基相隔两个原子.2. 图2中的x或y之一为氧,或者x-Y是双键.3. N-酰基部分具有较小的疏水取代基,如f,Cl或me在rα,Rβ,Rη位置,并且整个分子具有适当的亲水-疏水平衡.利用这些制剂增强胰岛素吸收,为口服胰岛素治疗提供了新的途径.
DOI:10.1248/cpb.36.4426

海关参考信息

2903919090-氯苯
2905590020-2-氯乙醇
2908191000-对氯苯酚
2912110000-甲醛
💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
详情请参考：📖 海关编码查询和海关进出口税则

专利信息

专利号:US-4734495-A
优先权日:1985-07-17
标题 :Process and intermediates for beta-lactam antibiotics
发明人：EVANS DAVID A; SJOGREN ERIC B
权利人:HARVARD COLLEGE
摘要:1-Benzyl(or substituted benzyl)-3Î²-[4(S)-aryloxazolidin-2-one-3-yl]-4Î²-(2-arylvinyl)azetidin-2-ones are provided via cycloaddition of a 4(S)-aryloxazolidin-2-one-3-ylacetyl halide and an imine formed with a benzylamine and a 3-arylacrolein, e.g. cinnamaldehyde. The azetidinones are useful chiral intermediates in an asymmetric synthesis of 1-carba(1-dethia)-3-hydroxy-3-cephem-4-carboxylic acids and esters and to monocyclic Î²-lactam antibiotics.

专利号:US-4870169-A
优先权日:1985-07-17
标题:Intermediates for beta-lactam antibiotics
发明人：EVANS DAVID A; SJOGREN ERIC B
权利人:HARVARD COLLEGE
摘要:1-Benzyl(or substituted benzyl)-3Î²-[4(S)-aryloxazolidin-2-one-3-yl]-4Î²-(2-arylvinyl)azetidin-2-ones are provided via cycloaddition of a 4(S)-aryloxazolidin-2-one-3-ylacetyl halide and an imine formed with a benzylamine and a 3-arylacrolein, e.g. cinnamaldehyde. The azetidinones are useful chiral intermediates in an asymmetric synthesis of 1-carba(1-dethia)-3-hydroxy-3-cephem-4-carboxylic acids and esters and to monocyclic Î²-lactam antibiotics.

专利号:US-4665171-A
优先权日:1985-07-17
标题:Process and intermediates for Î²-lactam antibiotics
发明人：EVANS DAVID A; SJOGREN ERIC B
权利人:UNIV HARVARD
摘要:1-Benzyl (or substituted benzyl)-3Î²-[4(S)-aryloxazolidin-2-one-3-yl]-4Î²-(2-arylvinyl)azetidin-2-ones are provided via cycloaddition of a 4(S)-aryloxazolidin-2-one-3-ylacetyl halide and an imine formed with a benzylamine and a 3-arylacrolein, e.g. cinnamaldehyde. The azetidinones are useful chiral intermediates in an asymmetric synthesis of 1-carba(1-dethia)-3-hydroxy-3-cephem-4-carboxylic acids and esters and to monocyclic Î²-lactam antibiotics.

专利号:US-9878999-B2
优先权日:2011-03-24
标题 :Proteasome chymotrypsin-like inhibition using PI-1833 analogs
发明人：LAWRENCE HARSHANI R; SEBTI SAID M; OZCAN SEVIL
权利人:H LEE MOFFITT CANCER CT & RES
摘要:Focused library synthesis and medicinal chemistry on an oxadiazole-isopropylamide core proteasome inhibitor provided the lead compound that strongly inhibits CT-L activity. Structure activity relationship studies indicate the amide moiety and two phenyl rings are sensitive toward synthetic modifications. Only para-substitution in the A-ring was important to maintain potent CT-L inhibitory activity. Hydrophobic residues in the A-ring's para-position and meta-pyridyl group at the B-ring significantly improved inhibition. The meta-pyridyl moiety improved cell permeability. The length of the aliphatic chain at the para position of the A-ring is critical with propyl yielding the most potent inhibitor, whereas shorter (i.e. ethyl, methyl or hydrogen) or longer (i.e. butyl, propyl and hexyl) chains demonstrating progressively less potency. Introduction of a stereogenic center next to the ether moiety (i.e. substitution of one of the hydrogens by methyl) demonstrated chiral discrimination in proteasome CT-L activity inhibition (the S-enantiomer was 35-40 fold more potent than the R-enantiomer).

专利号:US-5286736-A
优先权日:1990-11-22
标题 :Pyridyl compounds and pharmaceutical compositions containing these compounds
发明人：SOYKA RAINER; EISERT WOLFGANG; MUELLER THOMAS; WEISENBERGER JOHANNES
权利人:THOMAE GMBH DR K
摘要:New pyridyl derivatives of the formula ##STR1## wherein R 1 to R 6 , A, X and n are as defined herein, the enantiomers thereof, the cis- and trans-isomers thereof if R 4 and R 5 together represent a carbon-carbon bond, and the addition salts thereof. The new pyridyl derivatives have antithrombotic activity and thromboxane-mediated activities. The new compounds are also simultaneously thromboxane antagonists (TRA) and thromboxane synthesis inhibitors (TSH). They also have an effect on PGE 2 -production.