专利号:US-6770436-B1 优先权日:1996-11-14 标题:Chemical amplification for the synthesis of patterned arrays 发明人:BEECHER JODY E; GOLDBERG MARTIN J; MCGALL GLENN H 权利人:AFFYMETRIX INC 摘要:Radiation-activated catalysts (RACs), autocatalytic reactions, and protective groups are employed to achieve a highly sensitive, high resolution, radiation directed combinatorial synthesis of pattern arrays of diverse polymers. When irradiated, RACs produce catalysts that can react with enhancers, such as those involved in autocatalytic reactions. The autocatalytic reactions produce at least one product that removes protecting groups from synthesis intermediates. This invention has a wide variety of applications and is particularly useful for the solid phase combinatorial synthesis of polymers.
专利号:WO-2020032913-A1 优先权日:2018-08-04 标题:Process for synthesis of oroxylin a 发明人:MAJEED MUHAMMED; NAGABHUSHANAM KALYANAM; RAMANUJAM RAJENDRAN; HEMANTHA HOSAHALLI 权利人:MAJEED MUHAMMED; NAGABHUSHANAM KALYANAM; RAMANUJAM RAJENDRAN; HEMANTHA HOSAHALLI PRABHAKARA 摘要:Disclosed is a novel, simple, scalable and environment friendly process for the synthesis of Oroxylin A from Baicalin. Baicalm is esterified to obtain a methyl ester which is further selectively methylated to provide Oroxylin A gluciironide methyl ester which on de- glycosylation results in the formation of Oroxylin A.
专利号:WO-2025081225-A1 优先权日:2023-10-17 标 题 :Synthesis of polyphenols 发明人:TURLAND CADE LACHLAN; GROLMAN DAVID; BEHRENDORFF JAMES BRUCE YARNTON HAYCOCK; MORADI SHAYLI VARASTEH; THOMSON RAINE ELIZABETH STURT 权利人:Delica Therapeutics Pty Ltd 摘要:The present disclosure relates to polyphenols, including flavonoids, flavones and cannflavins, and methods of synthesising polyphenols. The present disclosure provides methods, enzymes and compositions that may be useful in the synthesis of polyphenols.
专利号:US-7951961-B2 优先权日:2006-07-07 标题:Enantioselective synthesis of pyrrolidines substituted with flavones, and intermediates thereof 发明人:SIVAKUMAR MEENAKSHI; SHUKLA MANOJ; JADHAV PRAMOD KUMAR; BORHADE AJIT 权利人:PIRAMAL LIFE SCIENCES LTD 摘要:The present invention relates to an enantioselective synthesis of (+)-trans enantiomer of pyrrolidines substituted with flavones, represented by Formula 1 or salts thereof, which are inhibitors of cyclin dependant kinases and can be used for treatment of proliferative disorders such as cancer n nwherein Ar has the meaning as indicated in the claims.
专利号:US-10407401-B1 优先权日:2018-08-04 标题 :Process for synthesis of Oroxylin A 发明人:MAJEED MUHAMMED; NAGABHUSHANAM KALYANAM; RAMANUJAM RAJENDRAN; HEMANTHA HOSAHALLI PRABHAKARA 权利人:MAJEED MUHAMMED; NAGABHUSHANAM KALYANAM; RAMANUJAM RAJENDRAN; HEMANTHA HOSAHALLI PRABHAKARA; SAMI LABS LTD 摘要:Disclosed is a novel, simple, scalable and environment friendly process for the synthesis of Oroxylin A from Baicalin. Baicalin is esterified to obtain a methyl ester which is further selectively methylated to provide Oroxylin A glucuronide methyl ester which on de-glycosylation results in the formation of Oroxylin A.
专利号:WO-2024260915-A1 优先权日:2023-06-19 标题:Dynamic covalent chemistry of spiropyrans for synthesis of photoswitchable photoinitiators and uses thereof 发明人:GARMSHAUSEN YVES 权利人:XOLO GMBH 摘要:The present invention relates to spiropyrans and process for the manufacture of them. In particular, a method is provided to exchange the indole and salicylaldehyde part of a spiropyran in a reversible reaction. The method is used for the synthesis of dual color photoinitiators with specific substituents and substitution patterns, which result in improved dual color volumetric printing (xolography). Furthermore, a process for locally polymerizing a starting material by dual color photopolymerization is disclosed.
参考文献:10.1515/znc-2009-11-1215 摘要:Islam MT. Variation in chemotactic preferences of Aphanomyces cochlioides zoospores to flavonoids. Z Naturforsch C J Biosci. 2009 Nov;64(11-12):847–52. doi: 10.1515/znc-2009-11-1215. 参考文献:10.1186/1475-2891-10-73 摘要:Bojić M, Debeljak Ž, Tomičić M, Medić-Šarić M, Tomić S. Evaluation of antiaggregatory activity of flavonoid aglycone series. Nutrition Journal. 2011 Jul 11;10(1):73. doi: 10.1186/1475-2891-10-73. 参考文献:10.1016/j.freeradbiomed.2011.06.021 摘要:Bensasson RV, Zoete V, Jossang A, Bodo B, Arimondo PB, Land EJ. Potency of inhibition of human DNA topoisomerase I by flavones assessed through physicochemical parameters. Free Radic Biol Med. 2011 Oct 01;51(7):1406–10. doi: 10.1016/j.freeradbiomed.2011.06.021. 参考文献:10.1007/s10895-011-0919-y 摘要:Shanker N, Dilek O, Mukherjee K, McGee DW, Bane SL. Aurones: Small Molecule Visible Range Fluorescent Probes Suitable for Biomacromolecules. Journal of Fluorescence. 2011 Jul 12;21(6):2173. doi: 10.1007/s10895-011-0919-y. 参考文献:10.1080/10286020.2011.586340 摘要:Wei H, Wu G, Lei Y, Xiong C, Ruan J. Neuropective constituents from the rhizomes ofAbacopteris penangiana. Journal of Asian Natural Products Research. 2011 Aug;13(8):707–13. doi: 10.1080/10286020.2011.586340.