CAS: 60-81-1; 1-(2,4-Dihydroxy-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(Hydroxymethyl)Tetrahydro-2H-Pyran-2-yl)Oxy)Phenyl)-3-(4-Hydroxyphenyl)Propan-1-One

该化合物是一种植物衍生的甘油表面化合物,表现出强大的α-甘醇-甘醇-甘油抑制剂活动,为管理2型糖尿病和相关代谢紊乱提供了潜在的治疗好处. 它独特的行动机制涉及对碳水化合物消化进行竞争性抑制,从而减少了葡萄糖吸收并改进了甘油控制.

结构式图片

相似化合物

7061-54-3 10366-91-3 14259-46-2

欧盟法规

REACH注册ECHA物质C&L通报REACH预注册

上下游产品

CAS号4547-85-7 Isosalipurposide | CAS号123-08-0 4-羟基苯甲醛; 对羟基苯甲醛 | CAS号60-82-2 根皮素 | CAS号2280-44-6 D-glucopyranose

合成工艺路线路线简述

    海关参考信息

    专利信息


    专利号:US-5350864-A
    优先权日:1990-05-03
    标 题:Aminoalkylcarbamyl derivatives of forskolin as intermediates for the synthesis of useful forskolin derivatives
    发明人:SEAMON KENNETH B; ROBBINS JOAN; LAURENZA ANTONIO
    权利人:US HEALTH
    摘要:The subject matter of the present invention relates to aminoalkylcarbamates of forskolin and the methods of using these compounds. Specifically, the aminoalkylcarbamates may be utilized in the synthesis of forskolin derivatives. The final derivatives may, in turn, be used in the development of in vivo and in vitro assays designed to study different proteins.

    专利号:US-5043328-A
    优先权日:1986-05-09
    标 题 :Formulations containing unsaturated fatty acids for the synthesis of prostaglandins and hydroxy-fatty acids in biological systems
    发明人:WEITHMANN KLAUS U
    权利人:HOECHST AG
    摘要:The present invention relates to formulations containing unsaturated fatty acids for the synthesis of prostaglandins and hydroxy-fatty acids in biological systems and to the use of such formulations for the preparation of medicaments which are suitable for curing prostaglandin deficiencies in humans or animal, for example healing or preventing diseases of the gastro-intestinal tract.

    专利号:WO-2007119717-A1
    优先权日:2006-04-13
    标题 :Process for production of intermediate aldohexopyranose
    发明人:WADA HISAYA
    权利人:TAISHO PHARMACEUTICAL CO LTD; WADA HISAYA
    摘要:Disclosed is an industrially advantageous process for producing a 2,3,4,6-tetra-O-acyl-D-aldohexopyranose derivative and a 2,3,4,6-tetra-O-acyl-5-thio-D-aldohexopyranose derivative in a safe manner and with high yield. A 2,3,4,6-tetra-O-acyl-D-aldohexopyranose derivative and a 2,3,4,6-tetra-O-acyl-5-thio-D-aldohexopyranose derivative are useful as intermediates for the synthesis of an aryl β-D-aldohexopyranoside derivative and an aryl 5-thio-β-D-aldohexopyranoside derivative, respectively, which are promising agents for treatment of diabetes or the like. The process comprises reacting a 1,2,3,4,6-penta-O-acylaldohexopyranose or a 1,2,3,4,6-penta-O-acyl-5-thioaldohexopyranose with an amine represented by the formula: R6NH2 or a salt thereof in the presence or absence of an acid or a salt thereof or a base, thereby producing a 2,3,4,6-tetra-O-acylaldohexopyranose or a 2,3,4,6-tetra-O-acyl-5-thioaldohexopyranose, respectively.

    专利号:US-2007232495-A1
    优先权日:2006-03-24
    标题:Compositions and methods to add value to plant products, increasing the commercial quality, resistance to external factors and polyphenol content thereof
    发明人:NAPPA ALVARO O; LORENZINI FELIPE C; SANHUEZA ANDRES L
    权利人:NAPPA ALVARO O; LORENZINI FELIPE C; SANHUEZA ANDRES L
    摘要:The invention is related to compositions and methods that naturally protect plant tissues against ultraviolet radiation and temperature, thus giving protection against sunburn to plants, plant parts, fruits and/or flowers during their development. The invention is also related to compositions and methods to naturally improve the color of plants, plant parts, fruits and/or flowers by inducing the natural synthesis of flavonoids and anthocyanins present in plants. Likewise, the present invention is directed to improving the nutritional value of plants, plant parts, fruits and/or flowers by increasing the normal levels of polyphenolic compounds, especially flavonoids, present therein. Additionally, the present invention is related to compositions and methods that give more resistance to plants, plant parts, fruits and/or flowers against pathogens as bacteria and fungi. Finally, the present invention is related to plants, plant parts, fruits, flowers and/or propagating material treated with the compositions described in the present document.

    专利号:US-2025231101-A1
    优先权日:2024-01-11
    标 题 :Validation of natural matrices for therapeutic use on humans, animals and plants on bio-physical bases as an alternative to validation through chemically definable substances derived from said matrices by isolation and/or synthesis processes and also as an alternative to products comprising natural matrices validated on the basis of their traditional use
    发明人:MERCATI VALENTINO; LUCCI JACOPO
    权利人:BIOS THERAPY PHYSIOLOGICAL SYSTEMS FOR HEALTH S P A
    摘要:The present invention relates to a new method for assessing acceptability ranges or cut-offs for the compliance validation of batches of products comprising or consisting of one or more natural matrix, wherein said products have an ascertained therapeutic or beneficial effect. The invention also relates to a new process for the compliance validation of one or more batches of said products.

    专利号:US-9775856-B2
    优先权日:2012-03-09
    标题 :C-glycosylpolyphenol antidiabetic agents, effect on glucose tolerance and interaction with beta-amyloid. therapeutic applications of the synthesized agent(s) and of Genista tenera ethyl acetate extracts containing some of those agents
    发明人:GRASES SANTOS SILVA RAUTER AMÉLIA PILAR; XAVIER DE JESUS ANA RITA; MENDES MARTINS ALICE ISABEL; DOS SANTOS DIAS CATARINA ALEXANDRA; TAVARES RIBEIRO ROGÉRIO JOSÉ; BORGES DE LEMOS MACEDO MARIA PAULA; GUERRA JUSTINO JORGE ALBERTO; DIAS MOTA FILIPE HELDER; AMARO PINTO RUI MANUEL; NOGUEIRA SEPODES BRUNO MIGUEL; PATRÃ?CIO GOULART DE MEDEIROS MARGARIDA ALEXANDRA; JIMENÉZ BARBERO JESUS; AIROLDI CRISTINA; NICOTRA FRANCESCO
    权利人:FACULDADE DE CIENCIAS DA UNIV DE LISBOA
    摘要:The present invention concerns the antidiabetic-activity of compounds type A, namely of 8-β-D-glucosylgenistein, which is not toxic to eukaryotic cells and has demonstrated to produce complete normalization of fasting hyperglycaemia, to reduce excessive postprandial glucose excursion, to increase glucose-induced insulin secretion and insulin sensitivity. An alternative synthesis for this molecular entity and its binding ability to β-amyloid oligomers is also included in the present invention, which also comprises Genista tenera ethyl acetate extract for use as antihyperglycaemic, agent i.e. for lowering blood glucose levels in mammals that are pre-diabetic or have type 2 or type 1 diabetes. n The inhibitory activity of α-glucosidase by Genista tenera ethyl acetate and butanol extracts and that of glucose-6-phosphatase by these two extracts and the diethyl ether plant extract is also part of the present invention.
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    主要参考文献


    1: Liu Z, Yang Y, Xu Y, Zhang Z, Tang R, Liu J, Jiang H, Zhao R. Procyanidin B1 and p-coumaric acid from whole highland barley ameliorated HFD-induced impaired glucose tolerance via small intestinal barrier and hepatic glucose metabolism. Food Funct. 2024 Aug 20. doi: 10.1039/d4fo02805h. Epub ahead of print.
    12:1428988. doi: 10.3389/fbioe.2024.1428988.
    3: Almalki A, Arjun S, Harding I, Jasem H, Kolatsi-Joannou M, Jafree DJ, Pomeranz G, Long DA, Yellon DM, Bell RM. SGLT1 contributes to glucose-mediated exacerbation of ischemia-reperfusion injury in ex vivo rat heart. Basic Res Cardiol. 2024 Aug 1. doi: 10.1007/s00395-024-01071-z. Epub ahead of print. 14(7):769. doi: 10.3390/biom14070769.

    合成参考文献


    摘要:Schafer, E. W., Jr., W. A. Bowles Jr., and J. Hurlbut. 1983. The acute oral toxicity and repellency and hazard potential of 998 chemicals to one or more species of wild and domestic birds. Archives of Environmental Contamination and Toxicology 12:355-382. https://www.aphis.usda.gov/ws/nwrc/chem-effects-db/Q_schafer832.pdf
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