专利号:US-2019047933-A1 优先权日:2016-03-15 标 题:Process for the synthesis of (2e, 4e, 6z, 8e)-8-(3,4-dihydronaphthalen-1(2h)-ylidene)-3,7-dimethylocta-2, 4, 6-trienoic acid 发明人:ABEL ULRICH; RÉPÃ?SI JÓZSEF; Szabó András; SZÜCSNÉ CSERÉPI STEFÃ?NIA; Bor Ã?dám 权利人:ABEL ULRICH; REPASI JOZSEF; SZABO ANDRAS; SZUECSNE CSEREPI STEFANIA; BOR ADAM; BRICKELL BIOTECH INC 摘要:This invention relates to a novel method for the synthesis of (2E,4E,6Z,8E)-8-(3,4-dihydronaphthalen-1(2H)-ylidene)-3,7-dimethylocta-2,4,6-trienoic acid. In particular, the invention relates to several improvements in several individual steps of the multi-step synthesis scheme
专利号:US-9994508-B2 优先权日:2012-12-11 标 题:Versatile and functionalised intermediates for the synthesis of vitamin D and novel vitamin D derivatives 发明人:LOPEZ PEREZ BORJA; SIGUEIRO PONTE RITA; MAESTRO SAAVEDRA MIGUEL A; MOURINO MOSQUERA ANTONIO 权利人:ENDOTHERM GMBH 摘要:Novel intermediates for the complete synthesis of vitamin D are provided that allow a great versatility of functional groups in the final vitamin derivatives. Vitamin derivatives that are epimeric in position 3 and vitamin derivatives with a wide range of functionalities in position 18, including compounds with isotopic labelling are provided.
专利号:WO-2025108575-A1 优先权日:2023-11-21 标 题:Methods of selective deprotection and synthesis of transhydrindane- skeleton-based compounds 发明人:HUBER FLORIAN MAURITIUS ERASMUS 权利人:ROCHE DIAGNOSTICS GMBH 摘要:The present invention relates to methods of selectively deprotecting a transhydrindane-skeleton-based compound comprising at least two different silyl ether groups. The present invention further relates to methods of synthesizing a Vitamin D molecule and to Vitamin D molecules obtainable by such processes. Furthermore, the present invention relates to a compound according to formula (I) comprising two different silyl ether groups, its use in the synthesis of Vitamin D molecules and to methods of producing such a compound.
专利号:US-7425629-B2 优先权日:2005-09-30 标 题:Stereoselective synthesis of certain trifluoromethyl-substituted alcohols 发明人:SONG JINHUA J; REEVES JONATHAN T; ROSCHANGAR FRANK; TAN ZHULIN; YEE NATHAN K 权利人:BOEHRINGER INGELHEIM PHARMA 摘要:A process for stereoselective synthesis of a compound of Formula (I) n nwherein R 1 , R 2 , R 3 , R 4 , and R 5 are as described herein.
专利号:US-5514821-A 优先权日:1994-05-27 标 题 :Ring-labeled retinoids and intermediates, and methods for their synthesis and use 发明人:BENNANI YOUSSEF L; BOEHM MARCUS F 权利人:LIGAND PHARM INC 摘要:Methods for the synthesis of dideuterium and/or ditritium ring-labeled retinoids and intermediates, and their use in the discovery of Retinoid X Receptor ligands are provided. In addition, dideuterium and/or ditritium ring-labeled retinoids and novel intermediates, as well as methods for their use in ligand binding and mass spectral studies are also provided.
专利号:US-3804882-A 优先权日:1970-08-05 标 题:Intermediates useful in the synthesis of vitamin a 发明人:JULIA M 权利人:RHONE POULENC SA 摘要:SULPHONES OF THE FORMULA: 1,3,3-TRI(ME-),2-(Q-OOC-CH=C(-ME)-CH(-SO2-R)-CH2-CH= C(-ME)-CH=CH-)CYCLOHEXENE IN WHICH R IS ARYL AND Q IS HYDROGLEN OR HYDROCARBON RADICAL, WHICH ARE MADE BY REACTING, PREFERABLY AT LOW TEMPERATURE. A HALIDE OF THE FORMULA: 1,3,3-TRI(ME-),2-(X-CH2-CH=C(-ME)-CH=CH-)CYCLOHEXENE AND A SULPHONE OF THE FPRMULA: R-SO2-CH2-C(-ME)=CH-COO-Q ARE USE FUL INTERMEDIATES FOR PRODUCING VITAMIN A INTO WHICH THEY MAY BE CONVERTED BY SAPONIFICATION, DESUPHONATION, AND REDUCTION.
[参考文献]: A I Gurova, Et Al. [参考文献]: Gig Tr Prof Zabol. 1985 Apr:(4):52-3. [参考文献]: Eric Leclerc, Et Al. Gas-Phase Reactivity Of The O=p(Och3)2 + Phosphonium Ion Towards Alpha,Beta-Unsaturated Esters In A Quadrupole Ion Trap. J Mass Spectrom. 2005 Apr;40(4):458-63. [参考文献]: N Ia Smoliar, Et Al. [参考文献]: Gig Sanit. 1984 Jan:(1):51-2.
合成参考文献
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