(Z)-1,4-Bis(Trimethylsilyl)-2-Butene置于三氟乙酸体系中,化学反应 3.0H,以100%的收率获得产物3-丁烯基三甲基硅烷 参考文献:Salimgareeva,I. M.; Zhebarov,O. Zh.; Bogatova,N. G.,Journal Of General Chemistry Of The Ussr,1981,Vol. 51,# 2,P. 342-346 标题:Salimgareeva,I. M.; Zhebarov,O. Zh.; Bogatova,N. G.,Journal Of General Chemistry Of The Ussr,1981,Vol. 51,# 2,P. 342-346
专利号:US-7230101-B1 优先权日:2002-08-28 标 题:Synthesis of methotrexate-containing heterodimeric molecules 发明人:MURTHI KRISHNA K; SMITH CHASE C 权利人:GPC BIOTECH INC 摘要:The present invention relates to novel compositions of methotrexate-containing heterodimeric probe molecules, also known as chemical inducers of dimerization (CID), useful in three-hybrid assays. The invention further relates to synthesis of said compositions and their intermediates. Another aspect of the invention is a method for using the heterodimeric probe molecules described herein in drug screens to identify potential protein targets to a given ligand, optimize protein-ligand interactions, or identify potential ligands for a given protein target. In certain embodiments, the invention contemplates the synthesis of the following methotrexate-containing heterodimeric probe:
专利号:US-2012215002-A1 优先权日:2009-10-09 标 题:Synthesis of optically active intermediate for the preparation of montelukast 发明人:LEFORT LAURENT 权利人:LEFORT LAURENT 摘要:The present invention relates to the synthesis of optically active alcohols by means of enantioselective hydrogenation of ketones in biphasic systems. In particular the present invention relates to the synthesis of an optically active alcohol of general formula (1).
专利号:US-8263784-B2 优先权日:2008-10-30 标 题 :Method for the synthesis of a ramipril intermediate 发明人:DE LANGE BEN; HEEMSKERK DENNIS 权利人:DE LANGE BEN; HEEMSKERK DENNIS; DSM SINOCHEM PHARM NL BV 摘要:The present invention relates to a process for the preparation of octahydrocyclopenta[b]pyrrole-2-carboxylic acid and esters thereof of general formula (1) in the presence of a cobalt and/or nickel comprising catalyst and to the use of compounds of general formula (1) in the synthesis of ramipril.
专利号:US-2005014954-A1 优先权日:2001-11-22 标 题:Pyrrole synthesis 发明人:OHRLEIN REINHOLD; BAISCH GABRIELE 摘要:The invention relates to a novel process for the preparation of N-substituted pyrroles, especially of formula (V), wherein the radicals are as defined in the description, by intermolecular aza-Wittig reaction starting from organic azides and 1,4-dioxo compounds. The invention relates also to novel iminophosphorane intermediates for this synthesis. The resulting pyrroles are useful, for example, in the organic synthesis of pharmaceuticals or other active substances and chemicals.
专利号:US-7193077-B2 优先权日:2003-08-30 标 题 :Exocyclic amine triaryl methyl protecting groups in two-step polynucleotide synthesis 发明人:DELLINGER DOUGLAS J; SIERZCHALA AGNIESZKA B; CARUTHERS MARVIN H 权利人:AGILENT TECHNOLOGIES INC 摘要:Precursors for use in the synthesis of polynucleotides and methods of using the precursors in synthesizing polynucleotides are disclosed. The precursors include a heterocyclic base having an exocyclic amine group and a substituted or unsubstituted triaryl methyl protecting group bound to the exocyclic amine group.
专利号:US-7427679-B2 优先权日:2003-08-30 标 题:Precursors for two-step polynucleotide synthesis 发明人:DELLINGER DOUGLAS J; SIERZCHALA AGNIESZKA B; CARUTHERS MARVIN H 权利人:AGILENT TECHNOLOGIES INC 摘要:Precursors for use in the synthesis of polynucleotides are disclosed. The precursors include a heterocyclic base having an exocyclic amine group and a substituted or unsubstituted triaryl methyl protecting group bound to the exocyclic amine group. In particular embodiments, the precursor has the structure: n nwherein:n O and H represent oxygen and hydrogen, respectively, R 1 is hydrido, hydroxyl, protected hydroxyl, lower alkyl, modified lower alkyl, or alkoxy, one of R 2 or R 3 is a hydroxyl protecting group; and the other of R 2 or R 3 is a reactive group capable of reacting with a reactive site hydroxyl, Base is a heterocyclic base having an exocyclic amine group, and Tram is a triaryl methyl group having the structure (V) n nwherein the broken line represents a bond to the amino nitrogen of the exocyclic amine group, and R 4 , R 5 and R 6 are independently selected from unsubstituted or substituted aryl groups, provided that at least one of R 4 , R 5 , and R 6 is an aryl group other than phenyl and other than substituted phenyl.