CAS: 765-50-4; 2-(Chloromethyl)Thiophene

该化合物是一种有机化合物,其特征是存在硫苯环,这是一个五人组成的芳香循环,含有硫磺.该化合物的特点是附于硫苯环第二碳的氯甲基组(-CH2Cl),使其成为硫苯替代物.该替代物对分子既引入反应场所,也引入极地特性,增强分子在各种化学反应中的再活动,如核生殖器替代物.2-(氯甲基)硫苯通常是一种无色的黄色色液体,具有独特的气味.它溶于有机溶剂中,在水中溶性有限.该化合物对有机合成和材料科学感兴趣,特别是在药品,农业化学品和功能材料的开发方面.在处理这一化合物时,应当采取安全防范措施,因为如果通过皮肤吸入或吸收,它可能会有害,因此最好在通风良好的地区或在烟雾盖下使用它.

结构式图片

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ECHA物质C&L通报REACH预注册

上下游产品

CAS号636-72-6 2-噻吩甲醇 | CAS号188290-36-0 Thiophene(SIV) | CAS号50-00-0 甲醛 | CAS号124-63-0 甲基磺酰氯 | CAS号98-03-3 2-噻吩甲醛 | CAS号554-14-3 2-甲基噻吩 | CAS号107-30-2 氯甲基甲醚 | CAS号39098-97-0 2-噻吩乙酰氯 | CAS号5928-51-8 3-(2-噻吩)丙酸 | CAS号98-03-3 2-噻吩甲醛 | CAS号4701-17-1 5-溴噻吩-2-甲醛 | CAS号4461-29-4 噻酚-2-乙酰胺 | CAS号4341-34-8 二(噻吩-2-基)甲烷 | CAS号19432-64-5 magnesium,2-met... | CAS号2168-83-4 methyl thiophen... | CAS号27757-85-3 2-噻吩甲胺 | CAS号1918-78-1 2-甲基-3-噻吩甲酸

合成工艺路线路线简述

  • 合成目标产物 2-(Chloromethyl)Thiophene 主要起始原料 2-Thiophenemethanol And Methanesulfonyl Chloride
  • (文献来源)合成步骤主要原料 2-Thiophenemethanol 和 Methanesulfonyl Chloride
Alkaline Earth Salt Of/the/ Methylsulfuric Acid置于氯体系中,用 溶剂黄146 作为反应溶剂,化学反应生成 2-氯甲基噻吩
参考文献:丁基和呋喃基钴肟的卤化
标题:丁基和呋喃基钴肟的卤化
摘要:丁基和呋喃基钴肟与乙酸和氯仿中卤素(溴和氯)的反应表明,Coc键断裂发生在2-乙烯基和2-呋喃基情况下,而环取代的速度快于coc带断裂. 3-乙烯基和3-呋喃基钴肟.
DOI:10.1016/s0040-4039(01)91024-X

海关参考信息

专利信息


专利号:US-4824532-A
优先权日:1987-01-09
标题:Process for the electrochemical synthesis of carboxylic acids
发明人:MOINGEON MARIE-ODILE; CHAUSSARD JACQUES; TROUPEL MICHEL; SABOUREAU CHRISTOPHE
权利人:AEROSPATIALE
摘要:The invention relates to a process for the electrosynthesis of carboxylic acids of general formula R-COOH in which R is an organic radical by the electrochemical reduction, in the presence of carbon dioxide, of organic compounds corresponding to the general formula R-Y in which R is the above-mentioned organic radical and Y is a hetero atom-containing radical, the hetero atom of the radical Y, chosen from the group consisting of oxygen, nitrogen, sulphur andphosphorus, being directly linked to a carbon atom of the radical R by a single covalent linkage. When the hetero atom is nitrogen or phosphorus, the radical Y is an ammonium or phosphonium radical respectively. The anode, which is consumed during the electrosynthesis, is made of a metal chosen from the group consisting of reducing metals and their alloys, preferably made of magnesium, aluminium or zinc. This process without catalyst is very simple to perform and enables a cell with a single compartment to be employed. The carboxylic acids are commonly employed in the chemical industry, especially as intermediates for the synthesis of pharmaceutical products or of products used in plant protection.

专利号:US-4221915-A
优先权日:1977-03-11
标题:Process for preparing thiophene derivatives and thiophene derivatives obtained thereby
发明人:KONDO KIYOSHI; TSUNEMOTO DAIEI; FUJISAWA TAMOTSU
权利人:SAGAMI CHEM RES
摘要:Process for the preparation of a series of thiophene derivatives, from which 2-thiopheneacetic acid derivatives can easily be prepared, in high yields and selectivity by using substituted or unsubstituted thiophenes as the starting materials by easy operations. 2-Thiopheneacetic acid derivatives are very useful compounds as the chemical modifier of penicillin and cephalosporin. Novel compounds, i.e. α-arylthio-2-thiopheneacetic acids are also disclosed. These compounds are useful as the intermediates of the synthesis of 2-thiopheneacetic acids.

专利号:US-2004254162-A1
优先权日:2001-07-16
标 题 :Oxazolidinone derivatives as antimicrobials
发明人:MEHTA ANITA; ARORA SUDERSHAN R; DAS BISJAWIT; RAY ABHIJIT; RUDRA SONALI; RATTAN ASHOK
摘要:The present invention relates to certain substituted phenyl oxazolidinones and to processes for the synthesis of the same. This invention also relates to pharma-ceutical compositions containing the compounds of the present invention as anti-microbials. The compounds are useful antimicrobial agents, effective against a number of human and veterinary pathogens, including gram-positive aerobic bacteria such as multiply-resistant staphylococci, streptococci and enterococci as well as anaerobic organisms such as Bacterioides spp. and Clostridia spp. species, and acid fast organisms such as Mycobacterium tuberculosis, Mycobacterium avium and Mycobacterium spp.

专利号:US-6956040-B2
优先权日:2001-07-16
标题:Oxazolidinone piperazinyl derivatives as potential antimicrobials
发明人:MEHTA ANITA; ARORA SUDERSHAN K; DAS BISWAJIT; RAY ABHIJIT; RUDRA SONALI; RATTAN ASHOK
权利人:RANBAXY LAB LTD
摘要:The present invention relates to certain substituted phenyl piperazinyl oxazolidinones, for example, to those having the structure of Formula I n n nwith the variables as defined within, and to processes for the synthesis of the same. This invention also relates to pharmaceutical compositions containing the compounds of the present invention as antimicrobials. The compounds are useful antimicrobial agents, effective against a number of human and veterinary pathogens, including gram-positive aerobic bacteria such as multiply-resistant staphylococci, streptococci and enterococci as well as anaerobic organisms such as Bacterioides spp. and Clostridia spp. species, and acid fast organisms such as Mycobacterium tuberculosis, Mycobacterium avium and Mycobacterium spp.

专利号:US-2477672-A
优先权日:1947-05-01
标 题 :Synthesis of nitriles
发明人:WEBB IRVING D; TABET GEORGES E
权利人:DU PONT

专利号:US-6734307-B2
优先权日:2000-07-17
标 题:Oxazolidinone derivatives as antimicrobials
发明人:MEHTA ANITA; SUDERSHAN ARORA K; DAS BISWAJIT; RAY ABHIJIT; RUDRA SONALI; RATTAN ASHOK
权利人:RANBAXY LAB LTD
摘要:The present invention relates to certain substituted phenyl oxazolidinones and to processes for the synthesis of the same. This invention also relates to pharmaceutical compositions containing the compounds of the present invention as antimicrobials. The compounds are useful antimicrobial agents, effective against a number of human and veterinary pathogens, including gram-positive aerobic bacteria such as multiply-resistant staphylococci, streptococci and enterococci as well as anaerobic organisms such as Bacterioides spp. and Clostridia spp. species, and acid fast organisms such as Mycobacterium tuberculosis, Mycobacterium avium and Mycobacterium spp.
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主要参考文献

参考标题:Discovery And Synthesis Of Novel Wogonin Derivatives With Potent Antitumor Activity In Vitro
作者:Jubo Wang,Raoling Ge,Xiaqiu Qiu,Xi Xu,Libin Wei,Zhiyu Li,Jinlei Bian |发布日期:2017.11
摘要:Effective Strategy To Obtain Novel Bioactive Compounds. Recently, Our Group Have Constructed A Wogonin-Scaffold Library With Substituents Diversity And Successfully Obtained A Series Of Potent Compounds. Herein, We Reported The Synthesis Of These Compounds And Evaluated The In Vitro Antitumor Activity Against A Panel Of Human Tumor Cell Lines. Most Of Them Showed Good Activity With A Broad Spectrum And

合成参考文献


摘要:Schatz, J.; Seler, M., Science of Synthesis Knowledge Updates, (2011) 2, 380.
摘要:Tang, R.-Y., Science of Synthesis: Knowledge Updates, (2024) 1, 421.
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