专利号:US-4824532-A 优先权日:1987-01-09 标题:Process for the electrochemical synthesis of carboxylic acids 发明人:MOINGEON MARIE-ODILE; CHAUSSARD JACQUES; TROUPEL MICHEL; SABOUREAU CHRISTOPHE 权利人:AEROSPATIALE 摘要:The invention relates to a process for the electrosynthesis of carboxylic acids of general formula R-COOH in which R is an organic radical by the electrochemical reduction, in the presence of carbon dioxide, of organic compounds corresponding to the general formula R-Y in which R is the above-mentioned organic radical and Y is a hetero atom-containing radical, the hetero atom of the radical Y, chosen from the group consisting of oxygen, nitrogen, sulphur andphosphorus, being directly linked to a carbon atom of the radical R by a single covalent linkage. When the hetero atom is nitrogen or phosphorus, the radical Y is an ammonium or phosphonium radical respectively. The anode, which is consumed during the electrosynthesis, is made of a metal chosen from the group consisting of reducing metals and their alloys, preferably made of magnesium, aluminium or zinc. This process without catalyst is very simple to perform and enables a cell with a single compartment to be employed. The carboxylic acids are commonly employed in the chemical industry, especially as intermediates for the synthesis of pharmaceutical products or of products used in plant protection.
专利号:US-4221915-A 优先权日:1977-03-11 标题:Process for preparing thiophene derivatives and thiophene derivatives obtained thereby 发明人:KONDO KIYOSHI; TSUNEMOTO DAIEI; FUJISAWA TAMOTSU 权利人:SAGAMI CHEM RES 摘要:Process for the preparation of a series of thiophene derivatives, from which 2-thiopheneacetic acid derivatives can easily be prepared, in high yields and selectivity by using substituted or unsubstituted thiophenes as the starting materials by easy operations. 2-Thiopheneacetic acid derivatives are very useful compounds as the chemical modifier of penicillin and cephalosporin. Novel compounds, i.e. α-arylthio-2-thiopheneacetic acids are also disclosed. These compounds are useful as the intermediates of the synthesis of 2-thiopheneacetic acids.
专利号:US-2004254162-A1 优先权日:2001-07-16 标 题 :Oxazolidinone derivatives as antimicrobials 发明人:MEHTA ANITA; ARORA SUDERSHAN R; DAS BISJAWIT; RAY ABHIJIT; RUDRA SONALI; RATTAN ASHOK 摘要:The present invention relates to certain substituted phenyl oxazolidinones and to processes for the synthesis of the same. This invention also relates to pharma-ceutical compositions containing the compounds of the present invention as anti-microbials. The compounds are useful antimicrobial agents, effective against a number of human and veterinary pathogens, including gram-positive aerobic bacteria such as multiply-resistant staphylococci, streptococci and enterococci as well as anaerobic organisms such as Bacterioides spp. and Clostridia spp. species, and acid fast organisms such as Mycobacterium tuberculosis, Mycobacterium avium and Mycobacterium spp.
专利号:US-6956040-B2 优先权日:2001-07-16 标题:Oxazolidinone piperazinyl derivatives as potential antimicrobials 发明人:MEHTA ANITA; ARORA SUDERSHAN K; DAS BISWAJIT; RAY ABHIJIT; RUDRA SONALI; RATTAN ASHOK 权利人:RANBAXY LAB LTD 摘要:The present invention relates to certain substituted phenyl piperazinyl oxazolidinones, for example, to those having the structure of Formula I n n nwith the variables as defined within, and to processes for the synthesis of the same. This invention also relates to pharmaceutical compositions containing the compounds of the present invention as antimicrobials. The compounds are useful antimicrobial agents, effective against a number of human and veterinary pathogens, including gram-positive aerobic bacteria such as multiply-resistant staphylococci, streptococci and enterococci as well as anaerobic organisms such as Bacterioides spp. and Clostridia spp. species, and acid fast organisms such as Mycobacterium tuberculosis, Mycobacterium avium and Mycobacterium spp.
专利号:US-2477672-A 优先权日:1947-05-01 标 题 :Synthesis of nitriles 发明人:WEBB IRVING D; TABET GEORGES E 权利人:DU PONT
专利号:US-6734307-B2 优先权日:2000-07-17 标 题:Oxazolidinone derivatives as antimicrobials 发明人:MEHTA ANITA; SUDERSHAN ARORA K; DAS BISWAJIT; RAY ABHIJIT; RUDRA SONALI; RATTAN ASHOK 权利人:RANBAXY LAB LTD 摘要:The present invention relates to certain substituted phenyl oxazolidinones and to processes for the synthesis of the same. This invention also relates to pharmaceutical compositions containing the compounds of the present invention as antimicrobials. The compounds are useful antimicrobial agents, effective against a number of human and veterinary pathogens, including gram-positive aerobic bacteria such as multiply-resistant staphylococci, streptococci and enterococci as well as anaerobic organisms such as Bacterioides spp. and Clostridia spp. species, and acid fast organisms such as Mycobacterium tuberculosis, Mycobacterium avium and Mycobacterium spp.
参考标题:Discovery And Synthesis Of Novel Wogonin Derivatives With Potent Antitumor Activity In Vitro 作者:Jubo Wang,Raoling Ge,Xiaqiu Qiu,Xi Xu,Libin Wei,Zhiyu Li,Jinlei Bian |发布日期:2017.11 摘要:Effective Strategy To Obtain Novel Bioactive Compounds. Recently, Our Group Have Constructed A Wogonin-Scaffold Library With Substituents Diversity And Successfully Obtained A Series Of Potent Compounds. Herein, We Reported The Synthesis Of These Compounds And Evaluated The In Vitro Antitumor Activity Against A Panel Of Human Tumor Cell Lines. Most Of Them Showed Good Activity With A Broad Spectrum And
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摘要:Schatz, J.; Seler, M., Science of Synthesis Knowledge Updates, (2011) 2, 380. 摘要:Tang, R.-Y., Science of Synthesis: Knowledge Updates, (2024) 1, 421.