CAS: 99-03-6; 1-(3-Aminophenyl)Ethanone

上下游产品

CAS号121-89-1 3-硝基苯乙酮 | CAS号2142-63-4 3-溴代苯乙酮 | CAS号54060-30-9 3-氨基苯乙炔 | CAS号99-02-5 3-氯苯乙酮 | CAS号70334-60-0 1-(3-azidopheny... | CAS号2454-37-7 3-(1-羟乙基)苯胺 | CAS号151224-49-6 (E)-1,1'-(diaze... | CAS号98-86-2 苯乙酮 | CAS号99-05-8 间氨基苯甲酸 | CAS号3125-71-1 3-乙酰基异硫氰酸苯酯 | CAS号56915-87-8 N-(3-乙酰基苯基)-2,2... | CAS号455-36-7 间氟苯乙酮 | CAS号52780-14-0 3-溴-Alpha-甲基苯甲醇 | CAS号55-21-0 苯甲酰胺 | CAS号1166988-10-8 1-(3-amino-2-br... | CAS号149914-98-7 1-(5-氨基-2-溴苯基)乙酮 | CAS号37148-51-9 3'-氨基-4'-溴苯乙酮 | CAS号51226-14-3 3-(2-甲基-1,3-二氧烷... | CAS号194783-82-9 TIMTEC-BB SBB000959

3-氨基苯乙炔置于甲醇体系中,用 水 作为反应溶剂,化学反应 0.5H,以79%的收率获得产物间氨基苯乙酮
参考文献:水溶性可重复使用的铑(i)催化剂介导的光诱导炔烃水合反应
标题:水溶性可重复使用的铑(i)催化剂介导的光诱导炔烃水合反应
摘要:在光化学辐射下,使用水溶性铑(i)催化剂,在水存在下芳基炔烃的水合反应以非常好的产率进行,从而得到相应的酮.该催化剂对内部和末端炔烃有效,并显示出高官能团相容性.低催化剂负载量,低温和较短的光解持续时间是反应的理想特征.该催化剂可以在有氧和含水条件下重复使用几次,体现了该催化剂的坚固特性.与已知的rh和其他金属催化剂相比,本反应为炔烃水合反应提供了显着的绿色方法.
DOI:10.1016/j.Catcom.2018.07.007

专利信息

专利号:US-7691635-B2
优先权日:2004-03-26
标题 :Labeling reagents, methods for the synthesis of such reagents and methods for the detection of biological molecules
发明人：LAAYOUN ALI; BERNAL-MENDEZ ELOY
权利人:BIOMERIEUX SA
摘要:The present invention relates to a temperature-stable labeling reagent of formula (0): n nin which:n R 1 represents H or an alkyl, aryl or substituted aryl group, R 2 represents a detectable marker or at least two detectable markers interlinked by at least one multimeric structure, L is a linker arm comprising a linear chain of at least two covalent bonds and n is an integer equal to 0 or 1, R 3 and R 4 represent, independently of one another: H, NO 2 , Cl, Br, F, I, R 2 -(L) n -Y—X—, OR, SR, NR 2 , R, NHCOR, CONHR, COOR, —CO—NH—(CH 2 ) 3 —(O—CH 2 —CH 2 ) 3 —CH 2 —NH—R 2 , —CO—NH—(CH 2 ) 3 —(O—CH 2 —CH 2 ) 4 —CH 2 —NH—R 2 with R=alkyl or aryl, A is a linker arm comprising at least one covalent double bond enabling the conjugation of the diazo function with the aromatic ring and u is an integer between 0 and 2, preferably 0 or 1, —Y—X— represents —CONH—, —NHCO—, —CH 2 O—, —CH 2 S—, —Z— represents —NH—, —NHCO—, —CONH— or —O—, m is an integer between 1 and 10, preferably between 1 and 3, and p is an integer between 1 and 10, preferably between 1 and 3. n The present invention also describes a method for the synthesis of said labels and also applications for the labeling of biological molecules, in particular of nucleic acids, with a labeling reagent bearing the diazomethyl function. n The invention is particularly suitable for use in the field of diagnostics.

专利号:EP-1383732-B1
优先权日:2001-05-04
标题:Labelling reagents, method for synthesis of said reagents and methods for detecting biological molecules
发明人：BOURGET CECILE; LHOMME JEAN; LAAYOUN ALI; KOTERA MITSUHARU; TREVISIOL EMMANUELLE; MENOU LIONEL; BERNAL MENDEZ ELOY
权利人:BIO MERIEUX; UNIV GRENOBLE 1; CENTRE NAT RECH SCIENT
摘要:The invention concerns a temperature-stable labelling reagent of formula (I), wherein: R<1> represents H or an alkyl, aryl or substituted aryl group; R<2> represents a detectable marker or at least two detectable markers linked together by at least a multimeric structure; L is a linking arm comprising a linear catemer concatenation of at least two covalent bonds; and n is an integer equal to 0 or 1; R<3> and R<4> represent, independently of each other: H, NO2, Cl, Br, F, I, R<2>-(L)n-Y-X-, OR, SR, NR2, R, NHCOR, CONHR, COOR with R = alkyl or aryl, A is a linking arm comprising at least a double bond enabling the conjugation of the diazo function with the aromatic cycle; and u is a whole number between 0 and 2, preferably between 0 and 1; and -Y-X- represents -CONH-, -NHCO-, -CH2O-, -CH2S-. The invention also concerns a method for the synthesis of said markers and uses for labelling biological molecules, in particular nucleic acids, with a labelling reagent bearing the diazomethyl function. The invention is particularly applicable in the field of diagnosis.

专利号:US-7737287-B2
优先权日:2002-03-28
标 题 :Anomeric derivatives of monosaccharides
发明人：MEUTERMANS WIM; WEST MICHAEL LEO; GIANG THANH LE; ADAMSON GEORGE; SCHAFER KARL; ABBENANTE GIOVANNI
权利人:ALCHEMIA LTD
摘要:This invention relates to combinatorial libraries of potentially biologically active mainly monosaccharide compounds and to methods of preparing same. These compounds are variously functionalized, with a view to varying lipid solubility, size, function and other properties, with the particular aim of discovering a drug or drug-like compound, or compounds with useful properties. The invention provides intermediates, processes and synthetic strategies for the solution or solid phase synthesis of monosaccharides, variously functionalized about the sugar ring, including the addition of aromaticity and charge, and the placement of amino acid and peptide side chain units of isosteres thereof.

专利号:US-6281245-B1
优先权日:1996-10-28
标 题:Methods for solid-phase synthesis of hydroxylamine compounds and derivatives, and combinatorial libraries thereof
发明人：PATEL DINESH V; NGU KHEHYONG
权利人:VERSICOR INC
摘要:A novel method for generating hydroxylamine, hydroxamic acid, hydroxyurea, and hydroxylsulfonamide compounds is disclosed. The method involves the nucleophilic attack of an alkoxyamine on a suitable solid phase support. Techniques of combinatorial chemistry can then be applied to the immobilized alkoxyamine to generate a diverse set of compounds. Cleavage of the compounds from the support yields a library of hydroxylamine or hydroxylamine derivative compounds, which can be screened for biological activity (e.g., inhibition of metalloproteinases).

专利号:US-9150497-B2
优先权日:2011-10-14
标题 :Continuous two step flow synthesis of M-amino acetophenone
发明人：KULKARNI AMOL ARVIND; JOSHI RAMESH ANNA; JOSHI ROHINI RAMESH
权利人:COUNCIL SCIENT IND RES
摘要:Disclosed herein is a continuous tubular reactor based conversion of acetophenones to amino substituted acetophenones wherein the nitration is carried out at −10 to 10° C. followed by reduction to m-nitrophenone resulting in uniform output of product, said process comprising the steps of: a) Nitrating acetophenone with nitrating agent (nitration mixture or fuming nitric acid) at −10 to 10° C.; b) Isolating m-nitro acetophenone from a mixture of o and m-nitro acetophenone and c) Reducing the m-nitro to obtain m-amino acetophenone.

专利号:US-6531470-B1
优先权日:1998-01-23
标题:Oxazolidinone combinatorial libraries, compositions and methods of preparation
发明人：GORDEEV MIKHAIL F; LUEHR GARY W; PATEL DINESH V; NI ZHI-JIE; GORDON ERIC
权利人:UPJOHN CO
摘要:Oxazolidinones and methods for their synthesis are provided. Also provided are combinatorial libraries comprising oxazolidinones, and methods to prepare the libraries. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising the oxazolidinones. The methods of library preparation include the attachment of oxazolidinones to a solid support. The methods of compound preparation in one embodiment involve the reaction of an iminophosphorane with a carbonyl containing polymeric support.