CAS: 121660-11-5; (2-Cyclopropyl-4-(4-Fluorophenyl)Quinolin-3-yl)Methanol

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CAS号154057-56-4 3-溴甲基-2-环丙基-4-(... | CAS号121659-86-7 2-环丙基-4-(4-氟苯基)... | CAS号121660-37-5 2-环丙基-4-(4-氟苯基)... | CAS号148516-11-4 2-环丙基-4-(4-氟苯基)... | CAS号32249-35-7 3-环丙基-3-氧代丙酸甲酯 | CAS号3800-06-4 2-氨基-4'-氟二苯甲酮 | CAS号6704-19-4 1-环丙基丙-1-酮 | CAS号765-43-5 环丙甲基酮 | CAS号586966-54-3 匹伐他汀叔丁酯 | CAS号147526-32-7 匹伐他汀钙 | CAS号121660-37-5 2-环丙基-4-(4-氟苯基)... | CAS号146578-99-6 匹伐他汀中间体PB3 | CAS号256431-72-8 (E)-3-[2-环丙基-4-... | CAS号154057-56-4 3-溴甲基-2-环丙基-4-(... | CAS号147489-06-3 6-[[(1E)-2-环丙基-... | CAS号148901-69-3 (E)-7-[2-环丙基-4-... | CAS号148901-68-2 (E)-3-[2-环丙基-4-... | CAS号147511-70-4 匹伐他汀中间体PB7

环丙基乙基甲酮置于n-溴代丁二酰亚胺(Nbs),水,对甲苯磺酸体系中,用 四氢呋喃,四氯化碳,甲苯,乙腈 用作溶剂,化学反应 176.0H,反应生成2-环丙基-4-(4-氟苯基)-3-喹啉甲醇
参考文献: Process For The Preparation Of Key Intermediates For The Synthesis Of Statins Or Pharmaceutically Acceptable Salts Thereof[fr] Procédé De Préparation D'Intermédiaires Clés Pour La Synthèse De Statines Ou Sels Pharmaceutiquement Acceptables De Ceux-Ci
标题: Process For The Preparation Of Key Intermediates For The Synthesis Of Statins Or Pharmaceutically Acceptable Salts Thereof[fr] Procédé De Préparation D'Intermédiaires Clés Pour La Synthèse De Statines Ou Sels Pharmaceutiquement Acceptables De Ceux-Ci
摘要:该发明涉及一种用于合成他汀类药物的关键中间体的商业可行工艺,特别是用于制备罗伪司汀和匹伐司汀或其相应的药用盐.提出了一种新的简单和短路的关键中间体合成路线,其受益于使用廉价且易获得的起始原料,从而避免了传统上最常用的dibal-H还原剂.

专利信息

专利号:US-9085538-B2
优先权日:2010-07-26
标题:Process for the preparation of key intermediates for the synthesis of statins or pharmaceutically acceptable salts thereof
发明人：CASAR ZDENKO; STERK DAMJAN; JUKIC MARKO
权利人:CASAR ZDENKO; STERK DAMJAN; JUKIC MARKO; LEK PHARMACEUTICALS
摘要:The invention relates to commercially viable process for the synthesis of key intermediates for the preparation of statins, in particular Rosuvastatin and Pitavastatin or respective pharmaceutically acceptable salts thereof. A new simple and short synthetic route for key intermediates is presented which benefits from the use of cheap and readily available starting materials, by which the conventionally most frequently used DIBAL-H as reducing agent can be avoided.

专利号:US-2014051854-A1
优先权日:2010-07-26
标题 :Process for the preparation of key intermediates for the synthesis of statins or pharmaceutically acceptable salts thereof

专利号:WO-2012013325-A1
优先权日:2010-07-26
标题 :Process for the preparation of key intermediates for the synthesis of statins or pharmaceutically acceptable salts thereof

专利号:EP-2423195-A1
优先权日:2010-07-26
标题 :Process for the preparation of key intermediates for the synthesis of statins or pharmaceutically acceptable salts thereof

专利号:EP-2598484-B1
优先权日:2010-07-26
标题:Process for the preparation of key intermediates for the synthesis of statins or pharmaceutically acceptable salts thereof

专利号:EP-2598484-A1
优先权日:2010-07-26
标 题:Process for the preparation of key intermediates for the synthesis of statins or pharmaceutically acceptable salts thereof