CAS: 137504-86-0; (4-Chloro-3-Fluorophenyl)Boronic Acid

相似化合物

627525-83-1 864759-63-7 2055778-26-0

上下游产品

CAS号60811-18-9 4-溴-1-氯-2-氟苯

4-溴-1-氯-2-氟苯置于正丁基锂,硼酸三异丙酯,盐酸体系中,用 四氢呋喃,Hexanes,水 用作溶剂,化学反应 18.25H,反应生成4-氯-3-氟苯硼酸
参考文献: Quinazolinone Derivatives Useful As Anti-Hyperalgesic Agents[fr] Derives De Quinazolinone Utilises Comme Agents Anti-Hyperalgesiques
标题: Quinazolinone Derivatives Useful As Anti-Hyperalgesic Agents[fr] Derives De Quinazolinone Utilises Comme Agents Anti-Hyperalgesiques
摘要:本发明涉及式(I)的喹唑啉酮,其中r1是卤素;A);B);或c);X是n或cr8;R2是卤素;硝基;C1-C6烷基羰基;C1-C6烷基或c3-C6环烷基;R3是c1-C6烷基;C1-C6烷氧基或氨基;以及进一步的基团具有规范中定义的含义,这些化合物具有人类辣椒素拮抗活性;用于它们的生产过程,它们作为药物的用途以及包括它们的药物组成物.

专利信息

专利号:US-12319691-B2
优先权日:2020-05-04
标题 :Heterocyclic compounds as triggering receptor expressed on myeloid cells 2 agonists and methods of use
发明人：CZABANIUK LARA C; HOPPER TIMOTHY; HOUZE JONATHAN B; RESCOURIO GWENAELLA; SANTORA VINCENT; WANG HAOXUAN; WHITE RYAN D; WONG ALICE R; WU YONGWEI
权利人:AMGEN INC; VIGIL NEUROSCIENCE INC
摘要:The present disclosure provides compounds of Formula I, useful for the activation of Triggering Receptor Expressed on Myeloid Cells 2 (“TREM2â€?).This disclosure also provides pharmaceutical compositions comprising the compounds, uses of the compounds, and compositions for treatment of, for example, a neurodegenerative disorder. Further, the disclosure provides intermediates useful in the synthesis of compounds of Formula I.

专利号:US-2008280933-A1
优先权日:2006-07-25
标 题:Benzimidazolyl compounds
发明人：EFREMOV IVAN; ROGERS BRUCE N; DUPLANTIER ALLEN J; ZHANG LEI; ZHANG QIAN; MAKLAD NOHA S; EVRARD EDELWEISS; BRODNEY MICHAEL A
权利人:EFREMOV IVAN; ROGERS BRUCE N; DUPLANTIER ALLEN J; ZHANG LEI; ZHANG QIAN; MAKLAD NOHA S; EVRARD EDELWEISS; BRODNEY MICHAEL A
摘要:Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula I n n n n n n n n n n as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.

专利号:US-2008312271-A1
优先权日:2006-07-25
标 题 :Azabenzimidazolyl compounds
发明人：EFREMOV IVAN; ROGERS BRUCE N; DUPLANTIER ALLEN J; ZHANG LEI; ZHANG QIAN; MAKLAD NOHA S
权利人:PFIZER
摘要:Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula I n n n n n n n n n n as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.