CAS: 29091-09-6; 2,4-Dichloro-3,5-Dinitrobenzotrifluoride

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CAS号320-60-5 2,4-二氯三氟甲苯 | CAS号7664-93-9 硫酸 | CAS号98-56-6 4-氯三氟甲苯 | CAS号29091-20-1 3-chloro-2,6-di... | CAS号29091-21-2 氨氟乐灵 | CAS号79622-59-6 氟啶胺 | CAS号36438-51-4 3-chloro-N,N-di... | CAS号70757-02-7 3-chloro-N-(2,6... | CAS号70757-03-8 3-chloro-N-(2,4... | CAS号67278-03-9 4-chloro-1,3-di... | CAS号67364-61-8 4-chloro-1,3-di... | CAS号79614-60-1 3,5-dichloro-N-...

1,3-二氯-2-硝基-4-(三氟甲基)-苯置于硫酸,硝酸,焦硫酸体系中,化学反应 14.58H,以81.4%的收率获得2,4-二氯-3,5-二硝基三氟甲苯
参考文献:一种2,4-二氯-3,5-二硝基三氟甲苯的制备方法
标题:一种2,4-二氯-3,5-二硝基三氟甲苯的制备方法
摘要:本发明公开了一种2,4‑二氯‑3,5‑二硝基三氟甲苯的制备方法,首先以2,4‑二氯三氟甲苯为原料进行第一步硝化反应,反应后相分离成废酸和硝化中间体;再将发烟硝酸和发烟硫酸混合成混酸,与硝化中间体进行第二步硝化反应,反应后相分离成半废酸和目标化合物2,4‑二氯‑3,5‑二硝基三氟甲苯;其中第二步硝化反应分离出来的半废酸可直接循环用于第一步硝化反应中,与2,4‑二氯三氟甲苯混合,进行新一轮的硝化反应.本发明的2,4‑二氯‑3,5‑二硝基三氟甲苯的制备方法在常压下分两步反应,操作简单,成品纯度高;第二步硝化产生的半废酸可供第一步硝化反应直接使用,即实现了循环经济,又减少了废酸排放.

专利信息

专利号:WO-2011092618-A1
优先权日:2010-01-28
标题 :Method for the preparation of fluazinam
发明人：PASTORIO ANDREA; MORA CLAUDIA
权利人:FINCHIMICA SRL; PASTORIO ANDREA; MORA CLAUDIA
摘要:A method for the synthesis of 3-chloro, N- (3-chloro-5- trifluoromethyl-2-pyridyl), α, α, α-trif luoro, 2,6-dinitro- p-toluidine (Fluazinam) comprises an amination reaction of a pyridine, to obtain 2-amino, 3-chloro, 5- trif luoromethylpyridine, the addition of a strong base to the 2-amino, 3-chloro, 5-trif luoromethylpyridine, and a formation reaction of Fluazinam by coupling of the 2- amino-3-chloro-5-trif luoromethylpyridine with the 2,4- dichloro, 3,5-dinitro, benzotrif luoride. The amination reaction is conducted with anhydrous ammonia in an organic solvent. Furthermore, the coupling reaction as above takes place directly in the solution of Pyridine 2 coming from the amination step.

专利号:US-8648203-B2
优先权日:2005-11-23
标 题:Process for preparing pyridinamines and novel polymorphs thereof
发明人：COHEN SHLOMI; ZAMIR SHARONA
权利人:COHEN SHLOMI; ZAMIR SHARONA; MAKHTESHIM CHEM WORKS LTD
摘要:The present invention relates to an improved process for the synthesis and purification of 3-chloro-N-(3-chloro-5-tri-fluoromethyl-2-pyridyl)-α,α,α-trifluoro-2,6-di-nitro-p-toluidine (fluazinam) and other pyridinamines, which implements methyl isobutyl ketone (MIBK) as the reaction solvent. The process of the invention overcomes the drawbacks of prior art methods, by reducing the side reactions such as hydrolysis, eliminating the need for difficult and labor-intensive purification methods, and providing pure products in higher yields. The present invention relates to novel crystalline polymorphic forms fluazinam, and to mixtures of the polymorphs. The present invention also provides methods for preparing the novel polymorphs, as well as pharmaceutical compositions comprising same, and methods of using the polymorphs as pesticidal agents for combating noxious living organisms on agricultural and horticultural crops.

专利号:CN-110143916-B
优先权日:2019-05-12
标题 :Synthesis process of fluazinam

专利号:CN-116162026-A
优先权日:2021-11-25
标 题:Synthesis method of 2, 4-dichloro-3, 5-dinitrobenzotrifluoride

专利号:CN-116162026-B
优先权日:2021-11-25
标 题:Synthesis method of 2, 4-dichloro-3, 5-dinitrobenzotrifluoride