专利号:US-11419952-B2 优先权日:2017-05-19 标 题 :Functionalized nanoparticles and methods of making and using same 发明人:MA KAI; WIESNER ULRICH B 权利人:UNIV CORNELL 摘要:Described is a versatile surface modification approach to, for example, modularly and orthogonally functionalize nanoparticles (NPs) such as, for example, PEGylated nanoparticles, ith various types of different functional ligands (functional groups) on the NP surface. It enables the synthesis of, for example, penta-functional PEGylated nanoparticles integrating a variety of properties into a single NP, e.g., fluorescence detection, specific cell targeting, radioisotope chelating/labeling, ratiometric pH sensing, and drug delivery, while the overall NP size remains, for example, below 10 nm.
专利号:US-12215078-B2 优先权日:2018-06-28 标题:Compositions and methods for protein labeling, modification, analysis, and targeted delivery 发明人:THAYUMANAVAN SANKARAN; VACHET RICHARD W; ZHUANG JIAMING; ZHAO BO 权利人:UNIV MASSACHUSETTS 摘要:The invention relates to chemically reactive and/or biologically active compounds, reagents and compositions thereof. More particularly, the invention provides novel reagents that are useful in chemical synthesis, functionalization, delivery, probing and/or analytical measurements of small molecule drugs, proteins, antibodies and other biomolecules. The invention provides novel biologically active agents useful as diagnostics or therapeutics, and related composition and methods of uses thereof.
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