专利号:US-9266902-B2 优先权日:2008-07-29 标题:Labelling reagents having a pyridine nucleus bearing a diazomethyl function, process for synthesis of such reagents and processes for detection of biological molecules 发明人:LAURENT ALAIN; LAAYOUN ALI; KOTERA MITSUHARA 权利人:LAURENT ALAIN; LAAYOUN ALI; KOTERA MITSUHARA; BIOMERIEUX SA; UNIV STRASBOURG; CENTRE NAT RECH SCIENT 摘要:A process for synthesis of a labelling reagent, a process for the labelling of a biological molecule, a labelled biological molecule obtained by the process, a process for labelling and fragmentation of a single or double strand nucleic acid, a labelled nucleic acid capable of being obtained by the process, a kit for detection of a target nucleic acid containing a labelled nucleic acid, a solid support onto which is attached a reagent and a process for capture of nucleic acids.
专利号:US-5002641-A 优先权日:1990-06-28 标题:Electrochemical synthesis of niacin and other N-heterocyclic compounds 发明人:TOOMEY JR JOSEPH E 权利人:REILLY IND INC 摘要:An electrochemical oxidation of a pi-deficient N-heterocyclic precursor compound having an oxidizable organic group attached by a carbon-to-carbon linkage. This precursor compound is at least sparingly water soluble. The preferred electro-oxidation is conducted at an effective anode and in a medium which consists essentially of water, carboxylic acid, and the precursor compound. Preferred are electro-oxidations of substituted pyridine and quinoline bases and a particularly preferred aspect provides a convenient electrochemical synthesis of niacin from 3-methylpyridine.
专利号:US-6174956-B1 优先权日:1995-06-02 标题 :Synthesis of condensation polymers in densified fluids 发明人:KERSCHNER JUDITH LYNNE; JURELLER SHARON HARRIOTT; THOMAIDES JOHN SOCRATES; HUMPHREYS ROBERT WILLIAM; IOVINE CARMINE PHILLIP 权利人:NAT STARCH CHEM INVEST 摘要:A polyurethane polymer and method of preparing it is described. The process requires the combination of a soluble polyol with a di- or polyisocyanate under densified fluid conditions. The process to prepare a waterborne polyurethane involves the utilization of a polyol containing ionic or latent ionic groups which must undergo preneutralization before combining with the di- or polyisocyanate under densified fluid conditions. The resulting polyurethane is substantially free of an organic solvent.
专利号:EP-2960274-A1 优先权日:2014-06-23 标题 :One pot synthesis of thermally reduced graphene oxide (TRGO)-polymer nanocomposites. 发明人:BOBENRIETH ALEXIS 权利人:SOLVAY 摘要:Process for manufacturing a thermally reduced graphene oxide-polymer nanocomposite from graphene oxide and monomer(s) comprising at least: n(A) a thermal reduction of graphene oxide, so as to form said thermally reduced graphene oxide, and n(B) a polymerization of the monomer(s) in the presence of said thermally reduced graphene oxide to yield said nanocomposite, n(A) and (B) being performed in the same reactor, nwherein polymerization (B) is only started when the oxygen content of the thermally reduced graphene oxide formed from the graphene oxide reaches a value below 15%. The present invention further relates to a nanocomposite and a Masterbatch obtainable by said process.
专利号:US-12071507-B2 优先权日:2014-01-10 标 题:Method and composition for improving adhesion of metathesis compositions to substrates 发明人:STEPHEN ANTHONY R; CRUCE CHRISTOPHER J; TRIMMER MARK S; GIARDELLO MICHAEL A 权利人:MATERIA INC 摘要:A method of improving the adhesion of metathesis compositions, such as ring-opening metathesis polymerization (ROMP) compositions, to a substrate is disclosed, in which an adhesion promoter is added to a polymerizable resin composition in order to improve the adhesion of the polymerizing resin to a substrate material. The addition of the adhesion promoter has been found to provide beneficial improvements in the adhesion of metathesis, especially ROMP, compositions to substrates, particularly glass surfaces, leading to improved characteristics in ROMP materials formed therefrom. The adhesion promoter generally comprises a functionalized silane compound and a peroxide compound. A ROMP composition is further disclosed comprising a cyclic olefin, a ROMP metathesis catalyst, and the adhesion promoter. Polymer products produced via metathesis (ROMP) reactions of the invention may be utilized to provide a wide range of materials and in a variety of composite applications. The invention has utility in the fields of catalysis, organic synthesis, and polymer and materials chemistry and manufacture.
专利号:US-9951181-B2 优先权日:2013-10-21 标题:Polyamides containing the bio-based 2,5-furandicarboxylic acid 发明人:SMITH DEEDEE; FLORES JOEL; ABERSON RENÉ; DAM MATHEUS ADRIANUS; DUURSMA ATE; GRUTER GERARDUS JOHANNES M 权利人:FURANIX TECHNOLOGIES BV; SYNVINA C V 摘要:Polyamides are made from the polycondensation of monomers including from 15 to 80 mol % of 2,5-furandicarboxylic acid (FDCA), from 20 to 85 mol % of at least one aromatic dicarboxylic acid and from 50 to 100 mol % of at least one aliphatic diamine selected from those including 6 and 7 carbon atoms. A process allowing the synthesis of high molecular weight polyamides made from the above mentioned monomers is also described. Finally, compositions and articles including the same polyamides are also disclosed.
1: Mishur RJ, Khan M, Munkácsy E, Sharma L, Bokov A, Beam H, Radetskaya O, Borror M, Lane R, Bai Y, Rea SL. Mitochondrial metabolites extend lifespan. Aging Cell. 2016 Apr;15(2):336-48. doi: 10.1111/acel.12439. Epub 2016 Jan 5. 2: Korczynska M, Le DD, Younger N, Gregori-Puigjané E, Tumber A, Krojer T, Velupillai S, Gileadi C, Nowak RP, Iwasa E, Pollock SB, Ortiz Torres I, Oppermann U, Shoichet BK, Fujimori DG. Docking and Linking of Fragments To Discover Jumonji Histone Demethylase Inhibitors. J Med Chem. 2016 Feb 25;59(4):1580-98. doi: 10.1021/acs.jmedchem.5b01527. Epub 2015 Dec 23. 3: Qi H, Jing Z, Xiaolin W, Changwu X, Xiaorong H, Jian Y, Jing C, Hong J. Histone Demethylase JMJD2A Inhibition Attenuates Neointimal Hyperplasia in the Carotid Arteries of Balloon-Injured Diabetic Rats via Transcriptional Silencing: Inflammatory Gene Expression in Vascular Smooth Muscle Cells. Cell Physiol Biochem. 2015;37(2):719-34. doi: 10.1159/000430390. Epub 2015 Sep 11. doi: 10.1016/j.str.2015.01.014. Epub 2015 Feb 26.
合成参考文献
参考文献:10.1107/s1600536811008452 摘要:Aghabozorg H, Jafarbak F, Mirzaei M, Notash B. Bis(1-methyl-4-oxoimidazolidin-2-iminium) diaquabis(pyridine-2,4-dicarboxylato-κ2N,O2)zincate(II) dihydrate. Acta Crystallogr E Struct Rep Online. 2011 Mar 12;67(4):m435–6. doi: 10.1107/s1600536811008452.