CAS: 51-35-4; (2S,4R)-4-Hydroxypyrrolidine-2-Carboxylic Acid

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32968-78-8 618-27-9 6912-67-0

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在 Palladium Dihydroxide 盐酸,氢气体系中,用 甲醇作为反应溶剂,反应 28.5H,获得 3-Hydroxy-Dl-Proline
参考文献:A Short-Step Synthesis Of 4-Hydroxyproline
标题:A Short-Step Synthesis Of 4-Hydroxyproline
摘要:新制备的 N-苄基-,N-二苯基甲基-或 N-(1-苯基丙基)-α-甲氧羰基甲亚胺 N-氧化物与丙烯醛在苯中反应,然后在氢氧化钯上进行氢解和酸水解,得到 4-羟基脯氨酸.
Doi:10.1246/Bcsj.54.3871

专利信息

专利号:US-12240808-B2
优先权日:2021-05-28
标 题 :Process for the synthesis of calebin-a and its intermediates
发明人：MAJEED MUHAMMED; NAGABHUSHANAM KALYANAM; MUTHUKAMAN NAGARAJAN; NAIDU PENTAKOTA PARADESI
权利人:MAJEED MUHAMMED; NAGABHUSHANAM KALYANAM; MUTHUKAMAN NAGARAJAN; NAIDU PENTAKOTA PARADESI
摘要:The invention discloses novel intermediates in the synthesis of Calebin A represented by formula 3. The invention also covers processes for the synthesis of Calebin-A and its analogs using compounds of formula 3.

专利号:US-4427587-A
优先权日:1982-11-10
标 题:Total synthesis of antitumor antibiotics BBM-2040A and BBM-2040B
发明人：KANEKO TAKUSHI; WONG HENRY S L
权利人:BRISTOL MYERS CO
摘要:A new chemical synthesis of the pyrrolobenzodiazepine antibiotics BBM-2040A and B is disclosed. The disclosed total synthesis uses readily available starting materials and provides a useful alternative to the microbiological procedure previously used to prepare these antibiotics.

专利号:US-9433605-B2
优先权日:2006-03-23
标 题 :Method for promoting synthesis of tissue collagen
发明人：KAMIYA TOSHIKAZU; KAMIMURA AYAKO; KAWADA YOKO
权利人:KYOWA HAKKO BIO CO LTD
摘要:An object of the present invention is to provide an oral preparation for promoting synthesis of tissue collagen, an oral preparation for promoting healing of skin wounds or an oral preparation for preventing or improving skin wrinkles or sagging, which is safe and has an excellent effect. The present invention can provide an oral preparation for promoting synthesis of tissue collagen, an oral preparation for promoting healing of skin wounds or an oral preparation for preventing or improving skin wrinkles or sagging, which comprises hydroxyproline or a salt thereof as an active ingredient.

专利号:US-7645858-B2
优先权日:2003-08-02
标 题:Method of peptide synthesis of peptides containing a proline residue or hydroxyproline residue at or adjacent to the C-terminal end of the peptide
发明人：STEWART ANDREW SMITH JOHNSTONE
权利人:ALMAC SCIENCES SCOTLAND LTD
摘要:A method for synthesizing a given peptide or its derivative which contains a proline residue or a proline derivative, at proximity to, or at, the C-terminal end of said peptide is provided. The method comprises a) synthesizing on a first resin a C-terminal portion of said peptide, or its derivative, comprising at least three successive amino acid residues or their derivatives, by successive coupling of selected amino acids, small peptides or their derivatives; b) cleaving the C-terminal portion from said first resin; c) reattaching said C-terminal portion to a second resin which is generally suitable for the synthesis of peptides but is unsuitable for the formation of peptides having a proline residue positioned at the C-terminal end of said peptide; and d) coupling selected amino acids, small peptides or derivatives to the C-terminal portion.

专利号:US-7317129-B2
优先权日:2002-06-07
标 题:Chemical synthesis of reagents for peptide coupling
发明人：RAINES RONALD T; KIESSLING LAURA L; NILSSON BRADLEY L; HE YI; SOELLNER MATTHEW B; HINKLIN RONALD J
权利人:WISCONSIN ALUMNI RES FOUND
摘要:The present invention provides improved methods for synthesis of phosphinothiol reagents, as well as novel protected reagents, for use in formation of amide bonds, and particularly, for peptide ligation. The invention provides phosphine-borane complexes useful as reagents in the formation of amide bonds, particularly for the formation of an amide bond between any two of an amino acid, a peptide, or a protein.

专利号:US-4242256-A
优先权日:1977-03-15
标 题 :Synthesis of peptide analogues
发明人：SHARPE ROBERT; SZELKE MICHAEL
权利人:SHARPE ROBERT; SZELKE MICHAEL
摘要:Compounds being analogues of a dipeptide in which the nitrogen atom of the linking amide group of the dipeptide is replaced by trivalent group ##STR1## and in which, optionally, the carbonyl function of this linking group is replaced by the divalent group --CH 2 -- are of value in the synthesis of isosterically modified peptides.