CAS: 54396-44-0; 2-Methyl-3-(Trifluoromethyl)Aniline

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N-(2,2-二甲基丙酰基)-3-(三氟甲基)苯胺置于氢氧化钾,正丁基锂体系中,用 乙二醇 作为反应溶剂,化学反应 12.0H,反应生成 2-甲基-3-三氟甲基苯胺
参考文献:Improved Process For The Preparation Of 2-Methyl-3-Trifluoromethylaniline: A Versatile Intermediate For Flunixin Synthesis
标题:Improved Process For The Preparation Of 2-Methyl-3-Trifluoromethylaniline: A Versatile Intermediate For Flunixin Synthesis
摘要:A Detailed New Experimental Investigation Into The Synthesis Of Flunixin Via 2-Methyl-3-Trifluoromethylaniline Is Described. The Coupling Process Between 2-Methyl-3-Trifluoromethylaniline And 2-Chloronicotinate Was Achieved Stoichiometrically And In High Yield,When Ethylene Glycol Was Used As Reaction Solvent At 160-Degrees-C.
DOI:10.3987/com-94-6822

专利信息

专利号:US-4209464-A
优先权日:1977-06-10
标题:Novel synthesis of 3-amino-2-methylbenzotrifluoride from N-(2-X-5-trifluoromethylphenyl)-S,S-dimethylsulfimide
发明人：STEINMAN MARTIN; WONG YEE S
权利人:SCHERING CORP
摘要:This invention relates to a novel process for preparing 3-amino-2-methylbenzotrifluoride, and to certain novel intermediates produced by the process. 3-Amino-2-methylbenzotrifluoride is a key intermediate useful in the preparation of valuable therapeutic agents such as, for example, 2-(2-methyl-3-trifluoromethyl)anilino nicotinic acid.

专利号:RU-94035759-A
优先权日:1991-12-20
标题 :Method of synthesis of 2-methyl-3-trifluoromethylaniline, derivatives of trifluoromethylpivalanilide and a method of their synthesis

专利号:US-5248781-A
优先权日:1992-09-21
标题 :Preparation of substituted anilino-nicotinic acid derivatives
发明人：MCKILLOP ALEXANDER
权利人:UNIV PRINCETON
摘要:Substituted anilino-nicotinic acid derivatives are readily prepared from the condensation of two intermediates, 2-alkyl-3-perfluoroalkyl-anilines and alkyl 2-chloronicotinates. The 2-alkyl-3-perfluoroalkyl-aniline intermediate can be prepared via a novel three step synthesis. 3-Perfluoroalkyl-anilines are reacted with an amine directing protecting group reagent to protect the amine. The protected amine is then alkylated, and finally, the directing group is removed to form the 2-alkyl-3-perfluoroalkyl-aniline intermediate. The 2-alkyl-3-perfluoroalkyl-aniline intermediate is condensed with the alkyl 2-chloronicotinate to form the anilino-nicotinic acid derivative.

专利号:IL-86787-A0
优先权日:1987-06-19
标题:Novel synthesis of 3-amino-2-methylbenzotrifluoride

专利号:US-4172095-A
优先权日:1977-06-10
标题 :Novel synthesis of 3-amino-2-methylbenzotrifluoride and the intermediates thereof

专利号:WO-8810247-A1
优先权日:1987-06-19
标题:Novel synthesis of 3-amino-2-methylbenzotrifluoride