亚苯甲基丙二酸二乙酯置于2,3-Dihydro-2-Phenyl-1H-Benzoimidazole体系中,化学反应生成 苄基丙二酸二乙酯 参考文献:Unprecedented Reaction Between Ethyl α-Cyanocinnamate And O-Phenylenediamine: Development Of An Efficient Method For The Transfer Hydrogenation Of Electronically Depleted Olefins 标题:Unprecedented Reaction Between Ethyl α-Cyanocinnamate And O-Phenylenediamine: Development Of An Efficient Method For The Transfer Hydrogenation Of Electronically Depleted Olefins 摘要:在热条件下,乙基α-氰基肉桂酸酯与邻苯二胺的反应反应生成了2-氰基-3-苯基丙酸乙酯,2-苯基苯并咪唑和乙基氰乙酸酯.机制上的揭示促成了一种简单高效的转移氢化过程,从原位反应生成的苯并咪唑啉到活化烯烃,在无溶剂和无催化剂的条件下进行. DOI:10.1055/s-2007-991087
专利号:US-5945548-A 优先权日:1995-03-03 标题:Process for the synthesis of α-substituted acrylic acids and their application 发明人:DUHAMEL PIERRE; DUHAMEL LUCETTE; DANVY DENIS; MONTEIL THIERRY; LECOMTE JEANNE-MARIE; SCHWARTZ JEAN-CHARLES 权利人:BIOPROJECT SOC CIV 摘要:Process for the synthesis of α-substituted acrylic acids of general formula (I) and their application to the synthesis of N-(mercaptoacyl)aminoacid derivatives of formula (II). ##STR1##
专利号:US-8257931-B2 优先权日:2005-01-21 标题 :Regulation of protein synthesis 发明人:WAGNER GERHARD; CHOREV MICHAEL; MOERKE NATHAN JOHN; AKTAS BERTAL HUSEYIN; HALPERIN JOSE 权利人:WAGNER GERHARD; CHOREV MICHAEL; MOERKE NATHAN JOHN; AKTAS BERTAL HUSEYIN; HALPERIN JOSE; HARVARD COLLEGE 摘要:A composition and method for inhibiting proliferation of a tumor cell compared to a non-tumor cell. Also described are methods of screening for a composition that inhibits cap-dependent translation compared to cap-independent translation of proteins.
专利号:US-5786494-A 优先权日:1995-03-03 标题:Process for the synthesis of α-substituted acrylic acids and their application
专利号:CA-2619153-C 优先权日:2005-01-21 标题:Regulation of protein synthesis by inhibition of eif4e-eif4g interaction
专利号:AU-2006206286-B2 优先权日:2005-01-21 标 题 :Regulation of protein synthesis by inhibition of eIF4E-eIF4G interaction
专利号:EP-1868604-A2 优先权日:2005-01-21 标 题 :Regulation of protein synthesis by inhibition of eif4e-eif4g interaction
[参考文献]: A Kreutzberger, Et Al. [参考文献]: Arzneimittelforschung. 1983;33(11):1517-8.
合成参考文献
摘要:von Angerer, S., Science of Synthesis Knowledge Updates, (2011) 1, 163. 摘要:Fan, Y. C.; Kwon, O., Science of Synthesis: Asymmetric Organocatalysis, (2012) 1, 754. 摘要:Uyanik, M.; Ishihara, K., Science of Synthesis: Catalytic Oxidation in Organic Synthesis, (2017) 1, 635. 摘要:Clark, K. F.; Dimitrova, D.; Murphy, J. A., Science of Synthesis, (2020) , 2.