CAS: 628-11-5; 3-Chloropropyl Carbonochloridate

该化合物是一种有机化合物,属于氯仿类,即氯仿酸酯酯,其特点是反应性,主要归因于氯化合物组和氯仿功能组的存在,其典型特征是无色的黄色液体,其香味不亮;该化合物以其作为有机合成的试剂的能力而著称,特别是在碳酸盐的形成和保护酒精方面;该化合物还被用于各种药物和农用化学品的合成中;由于其活性作用,3-氯丙基氯可具有危险性,需要在受控制的条件下谨慎处理和储存,以防止接触水分和空气,从而导致水解;安全防范,包括使用个人防护设备,在与该化合物合作减少与其腐蚀性和毒性有关的风险时至关重要.

结构式图片

相似化合物

627-11-2 638-41-5 628-09-1

欧盟法规

统一分类与标签压力设备指令-第1组危险流体REACH注册ECHA物质工作场所安全标识要求ECHA物质C&L通报REACH预注册废弃物危险特性清单

上下游产品

CAS号503-30-0 三甲氧基酯 | CAS号503-38-8 氯甲酸三氯甲酯 | CAS号75-44-5 光气 | CAS号627-30-5 3-氯-1-丙醇 | CAS号31121-11-6 3-苯氨基-1-丙醇 | CAS号1031927-07-7 4-[[(3-氯丙氧基)羰基]... | CAS号7507-38-2 1-Propanol, 3-c... | CAS号92952-76-6 2-chloro-4-(3-h... | CAS号6326-12-1 3-chloropropyl ...

合成工艺路线路线简述

    三甲氧基酯,氯甲酸三氯甲酯置于pentabutyl Propyl Guanidinium Chloride,Silica Gel体系中,化学反应 6.0H,以90%的收率获得产物3-氯-1-丙基氯甲酸酯
    参考文献:Reaction Of Epoxides With Chlorocarbonylated Compounds Catalyzed By Hexaalkylguanidinium Chloride
    标题:Reaction Of Epoxides With Chlorocarbonylated Compounds Catalyzed By Hexaalkylguanidinium Chloride
    摘要:Silica-Supported Guanidinium Chloride (Pbgsicl) Exhibits Efficient Chemo-And Regiospecific Catalytic Activity In The Ring Opening Of Epoxides With Various Electrophiles. This Reaction Allows The Preparation Of Beta-Chloro Esters And Beta-Chloro Chloroformates In High Yield-Under Neutral Conditions Which Offer Product Stability And Ease Of Product Isolation.
    DOI:10.1021/jo00096A040

    海关参考信息

    专利信息


    专利号:US-9657030-B2
    优先权日:2010-06-11
    标 题 :Transition metal-catalyzed processes for the preparation of N-allyl compounds and use thereof
    发明人:GIGUERE JOSHUA ROBERT; MCCARTHY KEITH EDWARD; REISCH HELGE ALFRED; SANDOVAL SERGIO; STYMIEST JAKE LARRY
    权利人:RHODES TECH
    摘要:The present disclosure provides processes for the N-dealkylation of tertiary amines and the use of transition metal catalysts to prepare tertiary N-allyl amine derivatives and secondary amine derivatives thereof. The tertiary amines can be alkaloids and, more particularly, the tertiary amines can be opioids. In specific embodiments, the present disclosure provides methods for use in processes for the synthesis of naloxone and naltrexone from oripavine.

    专利号:US-3998816-A
    优先权日:1973-04-16
    标题 :7-[5-N-(n-Butoxyethoxy carbonyl and 2-chloroethoxy carbonyl)-amino] cephalosporins C
    发明人:SEKI SHIGEO; ISHIMARU TOSHIYASU
    权利人:MEIJI SEIKA KAISHA
    摘要:New and useful cephem compounds derived from cephalosporin C are provided by this invention, which are valuable as intermediate for the synthesis of another bacteriocidally active cephem derivatives and which are readily extractable from its aqueous solution by means of an organic solvent and enable the cephalosporin C content in the aqueous fermentation broth filtrate to be recovered at an improved yield. Cephalosporin C present in the fermentation broth may be converted into the cephem compounds of this invention by reacting with a substituted chloroformate compound within said filtrate, and the cephem compounds so formed may then be extracted therefrom with an organic solvent. The cephem compounds of this invention further may be converted into a 7-acylamidocephalosporanic acid or 7-aminocephalosporanic acid through some successive reactions.

    专利号:CN-110668918-B
    优先权日:2019-10-22
    标 题 :The chemical synthesis method of 3-chloro-1-propanol

    专利号:CN-110668918-A
    优先权日:2019-10-22
    标 题:The chemical synthesis method of 3-chloro-1-propanol

    专利号:CN-119504882-A
    优先权日:2023-08-24
    标题 :Synthesis method of GalNAc derivative
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    合成参考文献


    参考文献:10.1007/10369757_68
    摘要:Chihara H, Nakamura N. Butene - Cobalt. . In: Landolt-Börnstein - Group III Condensed Matter.
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