专利号:US-9433605-B2 优先权日:2006-03-23 标 题 :Method for promoting synthesis of tissue collagen 发明人:KAMIYA TOSHIKAZU; KAMIMURA AYAKO; KAWADA YOKO 权利人:KYOWA HAKKO BIO CO LTD 摘要:An object of the present invention is to provide an oral preparation for promoting synthesis of tissue collagen, an oral preparation for promoting healing of skin wounds or an oral preparation for preventing or improving skin wrinkles or sagging, which is safe and has an excellent effect. The present invention can provide an oral preparation for promoting synthesis of tissue collagen, an oral preparation for promoting healing of skin wounds or an oral preparation for preventing or improving skin wrinkles or sagging, which comprises hydroxyproline or a salt thereof as an active ingredient.
专利号:WO-9900440-A1 优先权日:1997-06-26 标 题:Synthesis of a dendritic polyalcohol 发明人:IHRE HENRIK; HULT ANDERS 权利人:PERSTORP AB; IHRE HENRIK; HULT ANDERS 摘要:A process for a double stage convergent synthesis of a polymeric polyalcohol substantially and preferably built up from polyester units and composed of a monomeric or polymeric core to which at least one hyperbranched dendritic branch (dendron) consisting of a number of branching generations is added. The branching generations comprise a polymeric or monomeric branching chain extender having three reactive functions of which two are hydroxyl groups and one is a carboxyl group. The two hydroxyl groups of the branching chain extender is in a first step ketal protected by reacting said two hydroxyl groups with a ketal. A second step includes protection of the carboxyl group of said branching chain extender. The ketal protected branching chain extender and the carboxyl protected chain extender are then employed for repeated addition in a number of step yielding a predetermined number of branching generations. The thus synthesized dendron is finally added to a core having reactive hydroxyl or epoxide groups and the ketal protected hydroxyl groups are optionally deprotected.
专利号:US-6201101-B1 优先权日:1998-11-19 标 题:Catalyst and its use for the synthesis of polyol polyethers 发明人:TOZZOLA GABRIELLA; PO' RICCARDO; CARDI NICOLETTA 权利人:ENICHEM SPA 摘要:The present invention relates to a catalyst having general formula (I):wherein: M represents at least one cation of an element selected from earth-alkaline metals belonging to groups IIA, IIIA, VA, or transition metals belonging to groups IIB, IIIB, VB or VIIIB; n represents an integer between 0 and 2 and x is an integer between 2 and 5.The invention also relates to a process for the synthesis of polyol polyethers which uses a catalyst having general formula (I).
专利号:WO-2024121087-A1 优先权日:2022-12-07 标 题 :Process for the synthesis of polyesterols by ring-opening co-polymerisation of gamma-butyrolactone with other lactones 发明人:SCHAUB THOMAS; NICOLAS MATHIEU; FALCONNET ALBAN; HASHMI A STEPHEN K; KONRADI RUPERT; RODEWALD DIETER; BRUCHMANN BERND 权利人:BASF SE 摘要:Described are a process for the synthesis of polyesterols by ring-opening co-polymerisation of γ-butyrolactone with other lactones, the use of a kit comprising one or more bases comprising an alkaline metal cation and one or more alcohols in said process, and polyesterols obtainable by said process.
专利号:US-9597327-B2 优先权日:2005-05-25 标 题:Synthesis of (R)-N-methylnaltrexone 发明人:DOSHAN HAROLD D; PEREZ JULIO 权利人:PROGENICS PHARM INC 摘要:This invention relates to stereoselective synthesis of R-MNTX and intermediates thereof, pharmaceutical preparations comprising R-MNTX or intermediates thereof and methods for their use.
专利号:US-2009311292-A1 优先权日:2006-09-14 标题:Process for synthesis and incorporation of nitric oxide donors in macromolecular compositions 发明人:PACHECO OGARI; MOREIRA ROBERTO; SEABRA AMEDEA; SOUZA GABRIELA; OLIVEIRA MARCELO 权利人:CRISTALIA PROD QUIMICOS FARM; UNIV ESTADUAL DE CAMPINASUNICA 摘要:The present invention describes a process for the synthesis of S-nitrosothiols and the subsequent incorporation of these compounds in hydrophilic macromolecular compositions. By the process described herein, the S-nitrosothiols are synthesized in a device (FIG. 2 ) in a first step from the S-nitrosation reaction of their respective precursor thiols (A), promoted by a mechanical action that puts the thiols in contact with the nitrous acid formed from nitrite anions in acidic medium (B), and in a second mechanical operation, the freshly formed S-nitrosothiols are incorporated in an application vehicle (C) based on hydrophilic macromolecular compositions that increases their thermal stability. Therefore, the process under consideration combine the pre-application synthesis of S-nitrosothiols with their subsequent incorporation in delivery vehicles, with provide a relative stabilization of the S-nitrosothiols for sufficient periods so that the formulations prepared by this process may be stored in a domestic refrigerator during its time of use in its several possible applications.
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