CAS: 105-56-6; Ethyl Cyanoacetate

上下游产品

CAS号2141-62-0 3-乙氧基丙腈 | CAS号64-17-5 乙醇 | CAS号372-09-8 氰基乙酸 | CAS号74-90-8 氢氰酸 | CAS号105-39-5 氯乙酸乙酯 | CAS号773837-37-9 sodium cyanide | CAS号74-96-4 溴乙烷 | CAS号75-05-8 乙腈 | CAS号75-03-6 碘乙烷 | CAS号109-77-3 丙二腈 | CAS号1032-98-0 3-(2-benzothiaz... | CAS号112290-21-8 2-(4-Chlorophen... | CAS号108168-88-3 N-(叔-丁基)-2-氰基乙酰胺 | CAS号111038-10-9 ethyl 2-[1-(2-a... | CAS号109532-85-6 2-methylsulfany... | CAS号1114-73-4 Nonanoic acid,2... | CAS号111222-40-3 2-氨基-5-苯基-1H-吡咯... | CAS号112302-59-7 2-(Diphenylacet... | CAS号51093-34-6 2,6-diamino-1-m... | CAS号56-06-4 2,4-二氨基-6-羟基嘧啶

3-乙氧基丙腈置于cobalt(II) Acetate N-羟基邻苯二甲酰亚胺体系中,用 乙腈 用作溶剂,190.0 °C,900.01 Kpa 条件下,反应 7.0H,反应生成氰乙酸乙酯
参考文献:Method For Producing Cyanoacetic Acid Esters
标题:Method For Producing Cyanoacetic Acid Esters
摘要:一种生产一般式(i)的氰乙酸酯的方法:其中r代表一个可选择取代的直链或支链c1-8烷基或芳基c1-4烷基.根据该方法,在存在基于铅或过渡金属之一的催化剂的情况下,将一般式(II)的烷氧基丙腈:其中r如上所定义,氧化以形成所需的产物,使用氧气或氧化剂.

专利信息

专利号:US-2007259917-A1
优先权日:2006-04-24
标题 :Processes for the synthesis of 3-isobutylglutaric acid
发明人：KANSAL VINOD K; CHAURASIA BRIJNATH P; PATEL HITESH K; SHELKE SHIVAJI H; MORE YOGESH P
权利人:KANSAL VINOD K; CHAURASIA BRIJNATH P; PATEL HITESH K; SHELKE SHIVAJI H; MORE YOGESH P
摘要:Provided are processes for the synthesis of 3-isobutylglutaric acid, an intermediate in the synthesis of (S)-Pregabalin.

专利号:US-2010087525-A1
优先权日:2008-06-23
标 题:Stereoselective enzymatic synthesis of (s) or (r)-iso-butyl-glutaric ester
发明人：HEDVATI LILACH; STERIMBAUM GRETA; RAIZI YURIY; AMINOV RAHAMIN
权利人:HEDVATI LILACH; STERIMBAUM GRETA; RAIZI YURIY; AMINOV RAHAMIN
摘要:The present invention relates to a stereoselective enzymatic synthesis of (S) or (R)-iso-butyl-glutaric ester, an intermediate of S-Pregabalin.

专利号:US-9440940-B2
优先权日:2014-03-18
标 题:Methods for synthesis of psoralen derivatives
发明人：REFOUVELET BERNARD
权利人:MACOPHARMA S A S
摘要:Methods for the synthesis of psoralen derivatives are provided. In one embodiment, the method may include acetylating a compound of formula (II) to form a compound of formula (III), subjecting the compound of formula (III) to a Fries rearrangement to form a compound of formula (IV), and subjecting the compound of formula (IV) to cyclization, reduction and aromatization, to form a compound having the following formula (I):

专利号:US-4284582-A
优先权日:1978-04-28
标 题 :Process for the preparation of cyclopropane derivatives, intermediates in the synthesis of pyrethroid insecticides
发明人：KAYE ALBERT E; TUCKER ALAN C
权利人:ICI LTD
摘要:Compounds of formula: wherein both groups X are chlorine, bromine or trifluoromethyl, or one X is chlorine or bromine and the other is trifluoromethyl, and Y is -CN or -COOR in which R is an alkyl group, are obtained by (A) reacting a compound of the formula: wherein X1 is chlorine or bromine, with a compound of the formula: X2C=CH-CH=C(CH3)2 in the presence of metallic copper or at least one copper salt and a base, or (B) reacting a compound of the formula: Y-CH2-CN with a compound of the formula: X2C=CH-CH=C(CH3)2 and chlorine or bromine, in the presence of at least one reducible copper salt and a base, or (C) reacting a compound of formula: X-CH2-CN with a compound of the formula: wherein X1 is chlorine or bromine, in the presence of at least one copper salt. The compounds are intermediates in the synthesis of pyrethroid insecticides.

专利号:US-4713479-A
优先权日:1986-11-28
标题 :Synthesis of high-purity dialkyl 2-vinylcyclopropane-1,1-dicarboxylate
发明人：CLARK JR CLARENCE E; FAYTER JR RICHARD G
权利人:NAT DISTILLERS CHEM CORP
摘要:This invention relates to a two-step synthesis of high purity dialkyl 2-vinyl-cyclopropane-1,1-dicarboxylate in which a mixture of trans- and cis-1,4-dihalobutene-2 is first isomerized to essentially trans-1,4-dihalobutene-2 followed immediately by cyclocondensing the resultant trans-1,4-dihalobutene-2 with a malonic ester in the presence of an alcoholic solution of a metallic alkoxide.

专利号:WO-2012059797-A1
优先权日:2010-11-04
标题 :Process for synthesis of (s) - pregabalin
发明人：ROY BHAIRAB NATH; SINGH GIRIJ PAL; LATHI PIYUSH SURESH; AGRAWAL MANOJ KUNJABIHARI; MITRA RANGAN; RUPNAWAR MANOJ DATTATRAYA
权利人:LUPIN LTD; ROY BHAIRAB NATH; SINGH GIRIJ PAL; LATHI PIYUSH SURESH; AGRAWAL MANOJ KUNJABIHARI; MITRA RANGAN; RUPNAWAR MANOJ DATTATRAYA
摘要:Improved process for the synthesis of (S)-pregabalin having more than 99% ee through (S) 3-cyano-5-methyl-hexanoic acid has been developed. In addition to above, a novel process for resolution of ( RS ) - 3-cyano-5-methyl-hexanoic acid through diastereomeric salt formation with cinchonidine to obtain ( S ) - 3-cyano-5-methyl-hexanoic acid in high yield and high optical purity has been developed and furthermore process for recovery/ reuse of cinchonidine is also developed to improve the overall process efficiency.