CAS: 139481-58-6; Ethyl 1-((2'-(1H-Tetrazol-5-yl)-[1,1'-Biphenyl]-4-yl)Methyl)-2-Ethoxy-1H-Benzo[d]Imidazole-7-Carboxylate (Candesartan Cilexetil Ep Impurit)

相似化合物

139481-58-6 139481-59-7 139481-69-9

上下游产品

CAS号139481-41-7 1-((2'-氰基-[1,1'... | CAS号854538-88-8 ethyl 1-(4-brom... | CAS号155884-01-8 2-(5-四吡唑)苯硼酸 | CAS号139481-59-7 坎地沙坦

Ethyl 2-Ethoxy-1-[[2'-[(1-Methyl-1-Phenyl-Ethyl)-2H-Tetrazol-5-Yl]-[1,1']Biphenyl-4-Yl]Methyl]-1H-Benzoimidazole-7-Carboxylate置于palladium 10% On Activated Carbon Sodium Formate体系中,用 乙醇 用作溶剂,化学反应 72.0H,以60%的收率获得坎地沙坦乙酯
参考文献:Wo2006/134078
标题:Wo2006/134078

专利信息

专利号:US-8143435-B2
优先权日:2006-10-10
标题:One pot process for the preparation of candesartan
发明人：OM DUTT TYAGI; KARUSALA NAGESWARA RAO; TUMMALAPALLI UMA SANKARA SASTRY; BANDARI MOHAN; GORANTLA SEETA RAMANJANEYULU
权利人:OM DUTT TYAGI; KARUSALA NAGESWARA RAO; TUMMALAPALLI UMA SANKARA SASTRY; BANDARI MOHAN; GORANTLA SEETA RAMANJANEYULU; MYLAN LAB LTD
摘要:Present invention is to provide one pot synthesis of candesartan without isolating the ester intermediate.

专利号:US-7884212-B2
优先权日:2005-10-07
标题 :Process for the preparation of candesartan cilexetil
发明人：ZUPANCIC SILVO
权利人:ZUPANCIC SILVO
摘要:The present invention provides an improved synthesis for the manufacture of candesartan and pharmaceutically acceptable salts and esters thereof as active ingredients of a medicament for the treatment of hypertension and related diseases and conditions which comprises the removal of the tetrazolyl protecting group in an organic solvent, and in the presence of a Lewis acid.