CAS: 140898-91-5; Hexaminolevulinate Hydrochloride

5-氨基乙酰丙酸盐酸盐,正己醇置于氯化亚砜体系中,化学反应生成5-氨基酮戊酸己酯盐酸盐
参考文献:新的5-氨基乙酰丙酸衍生物作为原卟啉的前药在光动力疗法中的合成与评价
标题:新的5-氨基乙酰丙酸衍生物作为原卟啉的前药在光动力疗法中的合成与评价
摘要:原卟啉ix(ppix)在癌症的光动力诊断(pdd)和光动力疗法(pdt)中用作光敏剂,由5-氨基乙酰丙酸(5-Ala)前体在细胞内合成.设计并合成了13种新颖的5-Ala衍生物,具有定制的亲水性和亲脂性.检测的ppix的生成和它们的抗肿瘤活性在体外和体内也进行了研究.结果表明,化合物9B-c,11B-c和13A在小鼠纤维肉瘤s180细胞中孵育5小时后,在593 Nm处显示出特征性的长波吸收峰.在暴露于600 Nm激光照射后,这些化合物可在体外抑制s180细胞中的细胞增殖.这些化合物在体内可明显抑制s180细胞肿瘤在昆明小鼠中的生长.在这些化合物中,13A具有低的暗毒性和高的光毒性,这使其成为pdt的有效和有前途的前药.
Doi:10.1039/c7Pp00203C

专利信息

专利号:US-2009062211-A1
优先权日:2003-03-05
标 题:Conopeptides and methods of use
发明人：MARI FRANK; FIELDS GREGG B
权利人:UNIV FLORIDA ATLANTIC
摘要:Isolation, synthesis and therapeutic use of conotoxin and conophan compounds and related compositions including a new class of conopeptides including the modified amino acid D-γ-hydro-oxyvalinie (D-Hyv=V*) are described herein. These isolated peptides are the first known example of a naturally occurring polypeptide chain containing D-Hyv. The active peptides, termed γ-Hydroxyconophans are heavily hydroxylated small peptides. These peptides contain a definitive structural motif which is a double modification of the polypeptide chain (γ-D-OH-Hyv-Trp).

专利号:US-2006019892-A1
优先权日:2003-03-05
标 题:Conopeptides and methods of use
发明人：MARI FRANK
权利人:UNIV FLORIDA ATLANTIC
摘要:Isolation, synthesis and therapeutic use of compounds and related compositions based on a new class of conopeptides comprising the modified amino acid γ-hydroxyvaline (Hyv=V*). These isolated peptides are the first known example of a naturally occurring polypeptide chain containing Hyv. The active peptides, termed γ-Hydroxyconophans are heavily hydroxylated small peptides. These peptides contain a definitive structural motif which is a double modification of the polypeptide chain (γ-OH-Hyv-D-Trp).

专利号:US-12144874-B2
优先权日:2015-09-09
标题 :Synthesis and composition of photodynamic therapeutic agents for the targeted treatment of cancer
发明人：KULARATNE SUMITH A; GAGARE PRAVIN
权利人:ON TARGET LABORATORIES LLC; ON TARGET LABORATORIES INC
摘要:The present invention describes new compounds that are useful for image-guided surgery and photodynamic therapy. In particular the compounds may be targeted to the nucleus or the mitochondria after compounds were delivered to diseased tissues such as cancer using a ligand that target receptor that express on the diseased tissue and followed by receptor mediated endocytosis and provide effective activity against cancer cells as well as other disorders. Methods and compositions for use of the same are described.

专利号:US-10676487-B2
优先权日:2015-09-09
标 题 :Synthesis and composition of photodynamic therapeutic agents for the targeted treatment of cancer
发明人：KULARATNE SUMITH A; GAGARE PRAVIN; MYERS CARRIE H
权利人:ON TARGET LABORATORIES LLC
摘要:The present invention describes new compounds that are useful for image-guided surgery and photodynamic therapy. In particular the compounds may be targeted to the nucleus or the mitochondria after compounds were delivered to diseased tissues such as cancer using a ligand that target receptor that express on the diseased tissue and followed by receptor mediated endocytosis and provide effective activity against cancer cells as well as other disorders. Methods and compositions for use of the same are described.

专利号:WO-2025121735-A1
优先权日:2023-12-05
标 题 :Pharmaceutical composition comprising upconversion nanoparticles for preventing or treating cancer
发明人：KIM KI SU; CHOI HYE EUN; ANARA MOLKENOVA; LEE SU BIN
权利人:NAT UNIV PUSAN IND UNIV COOP FOUND
摘要:The present invention relates to a nano-platform comprising core-shell structured upconversion nanoparticles, a composition comprising same, and a treatment method, the nano-platform comprising: a core formed of NaYF4:Yb, Tm through single-step synthesis; and a shell, which encompasses the core and is formed of NaYF4:Nd.

专利号:EP-3347010-A1
优先权日:2015-09-09
标题:Synthesis and composition of photodynamic therapeutic agents for the targeted treatment of cancer