CAS: 170033-47-3; (R)-Tert-Butyl 2-Methylpiperazine-1-Carboxylate

相似化合物

169447-70-5 120737-78-2 1152110-23-0

上下游产品

CAS号170033-58-6 (R)-4-苄基-2-甲基哌嗪... | CAS号132871-11-5 1-苄基-3(R)-甲基哌嗪 | CAS号24424-99-5 二碳酸二叔丁酯 | CAS号132871-09-1 1-苄基-3-甲基-哌嗪-2,5-二酮 | CAS号474417-44-2 Piperazine, 3-m...

(R)-1-苄基-3-甲基哌嗪置于palladium Dihydroxide 氢气体系中,用 乙醇,二氯甲烷 用作溶剂,25.0 °C,241.32 Kpa 条件下,反应 32.0H,反应生成(R)-1-N-Boc-2-甲基哌嗪
参考文献:Asymmetric Synthesis Of 2,6-Methylated Piperazines
标题:Asymmetric Synthesis Of 2,6-Methylated Piperazines
摘要:The Complete Series Of Enantiopure 2,6-Methylated Piperazines Was Synthesized Utilizing Two Alternative Reactions In The Key Bond-Forming Step. The Dimethyl Enantiomers,(2R,6R)-And (2S,6S)-2,6-Dimethylpiperazine (1,2),Were Prepared Using Either A Diastereoselective Triflate Alkylation Or A Novel Intramolecular Mitsunobu Reaction To Set The Required Stereochemistry. The Monomethyl Derivatives,(R)-And (S)-Tert-Butyl 2-Methyl-1-Piperazinecarboxylate (3,4) Were Also Synthesized Employing The Mitsunobu Cyclization Strategy While The Trimethyl Compounds,(R)-And (S)-2,2,6-Trimethylpiperazine (5,6) Were Prepared Using An Enantiospecific Triflate Alkylation As The Principal Reaction. These Methods Represent Efficient,General Strategies For Preparing A Variety Of 2,6-Methylated Piperazines For Which The Absolute Stereochemistry Can Be Readily Controlled.
Doi:10.1021/jo00118A039

专利信息

专利号:CN-113636931-B
优先权日:2021-08-05
标题:Starting head fragment compound of genetically encoded compound library and its application in the synthesis of genetically encoded compound library

专利号:CN-1629146-A
优先权日:2003-12-19
标题 :Process for synthesis of chiral 2-substituted piperazine and its derivatives

专利号:CN-116444485-A
优先权日:2023-03-30
标题:Nonmetal-catalyzed, column-free synthesis of pyridyl-substituted asymmetric ureas

专利号:CN-113636931-A
优先权日:2021-08-05
标题 :Gene-encoded compound library starting head fragment compound and its application in the synthesis of gene-encoded compound library

专利号:CN-116444485-B
优先权日:2023-03-30
标题 :Metal-free catalytic, column-free chromatography synthesis method of pyridyl-substituted asymmetric urea