CAS: 18982-54-2; 2-Bromobenzyl Alcohol

上下游产品

CAS号6630-33-7 2-溴苯甲醛 | CAS号59184-20-2 (2-bromophenyl)... | CAS号610-94-6 2-溴苯甲酸甲酯 | CAS号109-63-7 三氟化硼乙醚 | CAS号88-65-3 邻溴苯甲酸 | CAS号3433-80-5 邻溴溴苄 | CAS号850335-71-6 2-bromo-1-[(eth... | CAS号94236-21-2 1-溴-2-((甲氧基甲氧基)甲基)苯 | CAS号7154-66-7 2-溴苯甲酰氯 | CAS号17100-66-2 2-[(2-bromophen... | CAS号54616-47-6 2-溴-N,N-二甲基苯甲酰胺 | CAS号52711-30-5 1-溴-2-(甲氧基甲基)苯 | CAS号38309-60-3 3H-螺[2-苯并呋喃-1,4'-哌啶] | CAS号42191-83-3 乙基螺环 | CAS号204192-41-6 spiro[1H-2-benz... | CAS号3433-80-5 邻溴溴苄 | CAS号87-41-2 苯酞 | CAS号6630-33-7 2-溴苯甲醛 | CAS号88-65-3 邻溴苯甲酸 | CAS号23450-18-2 2-溴二苯甲烷

2-溴苯甲酸置于sodium Tetrahydroborate,碘体系中,用 四氢呋喃 用作溶剂,化学反应 12.0H,反应生成2-溴苄醇
参考文献:克服分子间自由基加成醛的完全可逆性的策略:串联的c-h和c-o键使(苯氧基甲基)芳烃与羰基的环化裂解为苯并呋喃
标题:克服分子间自由基加成醛的完全可逆性的策略:串联的c-h和c-o键使(苯氧基甲基)芳烃与羰基的环化裂解为苯并呋喃
摘要:通过级联自由基偶联策略实现了碳自由基的分子间加成.它包括向羰基的分子间烷基加成,然后向卤代芳烃的分子内烷氧基加成,并以高收率产生取代的苯并呋喃.通过自由基捕获实验和epr分析,探索了该反应的自由基性质.通过kie实验和控制实验研究了该机理.该方法可以快速,实用地获得tam-16的关键中间体,Tam-16是治疗结核病的安全有效的抗菌剂,因此,对有机合成和制药工业具有重要意义.
Doi:10.1021/acs.Orglett.8B01207

专利信息

专利号:US-11236029-B2
优先权日:2019-05-17
标题 :Synthesis of a triangulene ring system and derivatives thereof
发明人：JOHNSON RICHARD PETER; HOLT CARTER J
权利人:THE UNIV OF NEW HAMPSHIRE; UNIV NEW HAMPSHIRE
摘要:A three step synthesis of the 8,12-dihydro-4H-dibenzo[cd,mn]pyren-3a 2 -ylium cation (triangulenium cation) is effected by cascade cyclization of a tetra-benzyl alcohol precursor in triflic acid solution. This cation is easily observed by NMR and optical spectroscopy. Quenching of the cation into basic solutions or by hydride transfer from triethylsilane provides access to stable dihydro and tetrahydro[3]triangulenes. This route makes several [3]triangulene precursors more readily available for development of new applications in the field of molecular electronics.

专利号:US-7102023-B2
优先权日:1999-11-24
标 题:Protecting groups useful in the synthesis of polysaccharides, natural products, and combinatorial libraries
发明人：BUCHWALD STEPHEN L; PLANTE OBADIAH J; SEEBERGER PETER H
权利人:MASSACHUSETTS INST TECHNOLOGY
摘要:One aspect of the present invention relates to optionally substituted halogenated benzyl halides and the like. These compounds are useful as halogenated benzyl ether-based protecting groups for a variety of functional groups. Another aspect of the present invention relates to use of said protecting groups in an orthogonal protecting group strategy for the synthesis of complex molecules that comprise a number of suitable functional groups. Another aspect of the present invention relates to saccharides bearing various arrays of protecting groups of the present invention. Another aspect of the present invention relates to a method of synthesizing an oligosaccharide or glycoconjugate, comprising the steps of: using a saccharide bearing at least one protecting group of the present invention to glycosylate a second molecule to give a product comprising said saccharide; and removing a protecting group of the present invention from said product.

专利号:US-2015045564-A1
优先权日:2012-01-03
标 题 :Cu-MEDIATED ANNULATION FOR THE EFFECTIVE SYNTHESIS OF 3-SUBSTITUTED PHTHALIDES
发明人：REDDY SANTHOSH REKULA; PRAGATI KISHORE PRASAD; NAGA KIRAN; SUDALAI ARUMUGAM
权利人:COUNCIL SCIENT IND RES
摘要:The present invention disclosed herein is a novel commercially feasible, one pot synthesis of library of 3-substituted phthalides of formula I via CuCN mediated oxidative cyclization in high yield. Formula I

专利号:US-3978140-A
优先权日:1974-09-23
标题 :Process for the preparation of carbinols
发明人：LANE CLINTON FISHER; MYATT HAL LESLIE
权利人:ALDRICH BORANES INC
摘要:Organic compounds containing a carboxylic acid or carboxylic acid anhydride group are reduced when contacted with an alkali metal borohydride and a boron trihalide in a liquid medium in which diborane is soluble in the form of a labile borane adduct. Hydrolysis of the reaction mixture then provides a useful synthesis of the corresponding carbinols. n The alkali metal borohydride-boron trihalide reagent may either be preformed and reacted subsequently with an organic compound containing a carboxylic acid or anhydride group, or the alkali metal borohydride-boron trihalide reagent may be produced in the presence of an organic compound containing a carboxylic acid or anhydride group. This development makes it possible to synthesize a wide variety of carbinols which are valuable and useful intermediates in organic synthesis.

专利号:US-12221419-B2
优先权日:2022-03-30
标题:Abietanes and methods of making and using the same
发明人：FREDERICH JAMES H; SOLANS MEGAN M
权利人:FLORIDA STATE UNIV RESEARCH FOUNDATION INCORPORATED; UNIV FLORIDA STATE RES FOUND
摘要:In accordance with the purpose(s) of the present disclosure, as embodied and broadly described herein is versatile polyene cyclization strategy that exploits conjugated β-ionyl derivatives. Photomediated disruption of the extended Ï€-system within these chromophores unveils a contra-thermodynamic polyene that engages in a Heck-type cyclization to afford [4.4.1]-propellanes. The connectivity of overbred polycycles generated from this process is controlled by the position of the requisite C-Halide bond. Thus, compared to conventional biomimetic polyene cyclization, this approach allows for complete control of regiochemistry and facilitates incorporation of both electron-rich and electron-deficient (hetero)aryl groups. This strategy was successfully applied to the total synthesis of abietanes such as, for example, taxodione and salviasperanol, two isomeric abietane-type diterpenes that previously could not be prepared along the same synthetic pathway.

专利号:US-8106031-B2
优先权日:2006-05-02
标题:Hydrolytically-resistant boron-containing therapeutics and methods of use
发明人：LEE VING; PLATTNER JACOB J; BENKOVIC STEPHEN J; BAKER STEPHEN J; MAPLES KIRK R; BELLINGER-KAWAHARA CAROLYN; AKAMA TSUTOMU; ZHANG YONG-KANG; SINGH RAJESHWAR; SAURO VITTORIO A
权利人:LEE VING; PLATTNER JACOB J; BENKOVIC STEPHEN J; BAKER STEPHEN J; MAPLES KIRK R; BELLINGER-KAWAHARA CAROLYN; AKAMA TSUTOMU; ZHANG YONG-KANG; SINGH RAJESHWAR; SAURO VITTORIO A; ANACOR PHARMACEUTICALS INC
摘要:Compositions and methods of use of boron derivatives, including benzoxaboroles, benzazaboroles and benzthiaboroles, as therapeutic agents for treatment of diseases caused by fungi, yeast, bacteria or viruses are disclosed, as well as methods for synthesis of said agents and compositions thereof.