专利号:US-12221646-B2 优先权日:2013-07-04 标 题:Method for the rapid determination of susceptibility or resistance of bacteria to antibiotics 发明人:FERNÃ?NDEZ GARCÃ?A JOSÉ LUIS; GOSÃ?LVEZ BERENGUER JAIME; SANTISO BRANDARIZ REBECA; TAMAYO NOVAS MARIA; BOU ARÉVALO GERMÃ?N 权利人:ABM TECH LLC 摘要:A method of rapidly evaluating the susceptibility of a strain of bacteria to a cell wall synthesis inhibiting antibiotic based on an assessment of cell enlargement in response to doses of the cell wall synthesis inhibiting antibiotic which are correlated to breakpoints of bacterial susceptibility.
专利号:US-8273403-B2 优先权日:2002-05-10 标题 :Generation of surface coating diversity 发明人:BARDEN MICHAEL C; KAMBOURIS PETER A 权利人:BARDEN MICHAEL C; KAMBOURIS PETER A; BIO LAYER PTY LTD 摘要:This invention relates to a surface discovery system and high-throughput combinatorial synthesis methods for generating large numbers of diverse surface coatings on solid substrates. The system is built upon a synthon which comprises at least three elements: a chemical backbone coating on the solid substrate that comprises a copolymer (B) of at least one passive constituent (P) and at least one active constituent (A); a spacer unit (S) separating the backbone from a functional group; and a functional group (F). The methods comprise the following steps: 1) selecting a plurality of synthons so that each synthon has at least two points of diversity selected from P, A, S and F; 2) applying copolymer B onto a substrate; and 3) attaching a combination of S and F to constituent A of copolymer B. Steps 2) and 3) are performed such that different synthons are generated on localized regions of the substrate.
专利号:DE-1921012-A1 优先权日:1968-04-29 标题:Process for the synthesis of antibacterial substances
专利号:CN-106831665-A 优先权日:2016-12-14 标题 :Enantioselective synthesis of γ-substituted-γ-butyrolactone and δ-substituted-δ-valerolactone
专利号:CN-109942473-A 优先权日:2019-05-16 标 题:A kind of method of catalyst-free synthesis lactam derivatives
专利号:US-2014315720-A1 优先权日:2012-10-24 标 题 :Polysaccharide ester microspheres and methods and articles relating thereto 发明人:FALLON DENIS G; GARRETT THOMAS S; KIZER LAWTON E; ZAZZARA KAREN L; COMBS MICHAEL T; JOHNSON RICHARD K; DEHART GARY 权利人:CELANESE ACETATE LLC 摘要:A method for producing a polysaccharide ester microsphere may include forming a polysaccharide ester product from a polysaccharide synthesis, wherein the polysaccharide ester product comprises a polysaccharide ester and a solvent; diluting the polysaccharide ester product, thereby yielding a polysaccharide ester dope; and forming a plurality of polysaccharide ester microspheres from the polysaccharide ester dope. Suitable polysaccharides may include, but are not limited to, starch, cellulose, hemicellulose, algenates, chitosan, and any combination thereof. Esters thereof may be organic esters (e.g., acetate and the like), inorganic esters (e.g., sulfonates and the like), or combinations thereof. Further, the solids conent of the polysaccharide ester dope, in some instances, may be greater than about 16 wt %.
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合成参考文献
摘要:Chemotherapy, 39(Suppl 参考文献:10.1007/s10096-011-1290-2 摘要:Hashino S, Morita L, Kanamori H, Takahata M, Onozawa M, Nakagawa M, Kawamura T, Fujisawa F, Kahata K, Izumiyama K, Yonezumi M, Chiba K, Kondo T, Asaka M. Clinical impact of cycling the administration of antibiotics for febrile neutropenia in Japanese patients with hematological malignancy. European Journal of Clinical Microbiology & Infectious Diseases. 2011 May 19;31(2):173–8. doi: 10.1007/s10096-011-1290-2. 参考文献:10.1007/s101560200026 摘要:Shibuya Y, Kitamura S, Tani G, Fukushima Y, Yatagai S, Nakamoto T, Motojima S. Evaluation of panipenem/betamipron (PAPM/BP) in pneumonia in elderly patients. J Infect Chemother. 2002 Jun;8(2):151–4. doi: 10.1007/s101560200026. 参考文献:10.1007/s101560200035 摘要:Kato K, Iwai S, Sato T, Harada T, Nakagawa Y, Iwanaga H, Ito Y, Takayama T. In-vitro activity of ciprofloxacin combined with flomoxef against Bacteroides fragilis, compared with that of ciprofloxacin combined with clindamycin. J Infect Chemother. 2002 Jun;8(2):190–3. doi: 10.1007/s101560200035.