CAS: 488798-37-4; Methyl 4-(4-Fluorophenyl)-6-Isopropyl-2-Oxo-1,2-Dihydropyrimidine-5-Carboxylate

异丁酰醋酸甲酯置于羟基乙叉二膦酸,硝酸体系中,用 乙醇 作为反应溶剂,化学反应 8.5H,反应生成 瑞舒伐他汀钙中间体rsb-3
参考文献:使用三聚磷酸钠在水中通过 Wittig 反应轻松合成 (E)-5-苯乙烯基嘧啶
标题:使用三聚磷酸钠在水中通过 Wittig 反应轻松合成 (E)-5-苯乙烯基嘧啶
摘要:已开发出一种廉价且环保的 Wittig 烯化方案来制备新型 (E)-5-苯乙烯基嘧啶.嘧啶鏻叶立德与不同芳基/杂芳基醛的反应在三聚磷酸钠 (Stpp) 存在下在水性条件下顺利进行,以非常高的产率 (77-96%) 得到 (E)-5-苯乙烯基嘧啶 (10A-T).
DOI:10.2174/1570178617999201012181526

专利信息

专利号:US-9085538-B2
优先权日:2010-07-26
标题:Process for the preparation of key intermediates for the synthesis of statins or pharmaceutically acceptable salts thereof
发明人：CASAR ZDENKO; STERK DAMJAN; JUKIC MARKO
权利人:CASAR ZDENKO; STERK DAMJAN; JUKIC MARKO; LEK PHARMACEUTICALS
摘要:The invention relates to commercially viable process for the synthesis of key intermediates for the preparation of statins, in particular Rosuvastatin and Pitavastatin or respective pharmaceutically acceptable salts thereof. A new simple and short synthetic route for key intermediates is presented which benefits from the use of cheap and readily available starting materials, by which the conventionally most frequently used DIBAL-H as reducing agent can be avoided.

专利号:US-2014051854-A1
优先权日:2010-07-26
标题 :Process for the preparation of key intermediates for the synthesis of statins or pharmaceutically acceptable salts thereof

专利号:WO-2012013325-A1
优先权日:2010-07-26
标题 :Process for the preparation of key intermediates for the synthesis of statins or pharmaceutically acceptable salts thereof

专利号:EP-2598484-B1
优先权日:2010-07-26
标题:Process for the preparation of key intermediates for the synthesis of statins or pharmaceutically acceptable salts thereof