-4-(三氟甲氧基)苯甲酸乙酯置于lithium Aluminium Tetrahydride,氢溴酸体系中,用 乙醚 作为反应溶剂,化学反应生成 4-三氟甲氧基溴苄 参考文献:Orda,V.V. Et Al.,Journal Of General Chemistry Of The Ussr,1965,Vol. 35,P. 1631-1637 标题:Orda,V.V. Et Al.,Journal Of General Chemistry Of The Ussr,1965,Vol. 35,P. 1631-1637
专利号:US-2025026768-A1 优先权日:2023-06-30 标题:Method for the synthesis of axially chiral organoboron compounds 发明人:PING YIFAN; CHE CHI-MING 权利人:LABORATORY FOR SYNTHETIC CHEMISTRY AND CHEMICAL BIOLOGY LTD 摘要:A highly efficient and atroposelective Rh-catalyzed [2+2+2] cycloaddition for the synthesis of axially chiral aryboron compounds is developed. The reactions of diynes and alkynylborons smoothly occur in an atom-economical manner, affording a variety of C—B atropisomers in excellent yields and enantioselectivities. The protocol features mild conditions, broad substrate scope, and good functional tolerance. The obtained C—B atropisomers show powerful synthetic applications in terms of producing novel chiral phosphine ligands.
专利号:US-7915276-B2 优先权日:2006-02-14 标题 :Berberrubine derivatives having antifungal activities 发明人:KIM SUNG UK; PARK KI DUK; MOON JAE SUN; KANG TAE HOON; KIM YOUNG KOOK 权利人:KOREA RES INST OF BIOSCIENCE 摘要:The present invention relates to a berberrubine derivative having superior antifungal activity, more particularly to a berberrubine derivative having activity against chitin synthase, which participates in the synthesis of chitin and is essential in the growth of fungi, and having a potent antifungal activity against human pathogenic fungi.
专利号:US-7470795-B2 优先权日:2004-07-27 标 题:Synthesis of 6,7-dihydro-5H-imidazo[1,2-a]imidazole-3-sulfonic acid amides 发明人:WANG XIAO-JUN; WIRTH THOMAS; NICOLA THOMAS; ZHANG LI; FRUTOS ROGELIO PEREZ; XU YIBO; KRISHNAMURTHY DHILEEPKUMAR; NUMMY LAURENCE JOHN; VARSOLONA RICHARD J; SENANAYAKE CHRIS HUGH; KROEBER JUTTA; REEVES DIANA 权利人:BOEHRINGER INGELHEIM PHARMA; BOEHRINGER INGELHEIM INT 摘要:Disclosed is a multi-step process for preparing a compound of Formula I: n nwherein R 1 to R 3 are as defined herein. The compounds of formula I inhibit the binding of human intercellular adhesion molecules to the Leukointegrins. As a result, these compounds are useful in the treatment of inflammatory and immune cell-mediated diseases.
专利号:WO-2023058903-A1 优先权日:2021-10-08 标 题:Automized micro combinatorial chemical reaction system and optimized combinatorial chemical synthesis method using same 发明人:KIM DONG-PYO; AHN GWANG-NOH 权利人:POSTECH RES & BUSINESS DEV FOUND 摘要:Disclosed are an automized micro combinatorial chemical reaction system and an optimized combinatorial chemical synthesis method using same. The automized micro combinatorial chemical reaction system comprises: a raw material supply unit (100); an intermediate reaction unit (200); an intermediate reaction control unit (300); and a first product reaction unit (400), and has the effect of producing plural types of products rapidly and at high yields.
专利号:WO-0010565-A1 优先权日:1998-08-18 标 题 :Growth hormone secretagogues 发明人:DODGE JEFFREY ALAN; HAUSER KENNETH LEE; HEIMAN MARK LOUIS; JONES SCOTT ALAN; ALT CHARLES ARTHUR; BRYANT HENRY UHLMAN; COHEN JEFFREY DANIEL; COPP JAMES DENSMORE; FAHEY KENNAN JOSEPH; GRITTON WILLIAM HARLAN; JUNGHEIM LOUIS NICKOLAUS; KENNEDY JOSEPH HENRY; LUGAR CHARLES WILLIS III; MUEHL BRIAN STEPHEN; PALKOWITZ ALAN DAVID; RATZ ANDREW MICHAEL; RHODES GARY ANTHONY; ROBEY ROBERT LEWIS; SEYLER DAVID EDWARD; SHEPHERD TIMOTHY ALAN; THRASHER KENNETH JEFF; TRANKLE WILLIAM GEORGE 权利人:LILLY CO ELI; DODGE JEFFREY ALAN; HAUSER KENNETH LEE; HEIMAN MARK LOUIS; JONES SCOTT ALAN; ALT CHARLES ARTHUR; BRYANT HENRY UHLMAN; COHEN JEFFREY DANIEL; COPP JAMES DENSMORE; FAHEY KENNAN JOSEPH; GRITTON WILLIAM HARLAN; JUNGHEIM LOUIS NICKOLAUS; KENNEDY JOSEPH HENRY; LUGAR CHARLES WILLIS III; MUEHL BRIAN STEPHEN; PALKOWITZ ALAN DAVID; RATZ ANDREW MICHAEL; RHODES GARY ANTHONY; ROBEY ROBERT LEWIS; SEYLER DAVID EDWARD; SHEPHERD TIMOTHY ALAN; THRASHER KENNETH JEFF; TRANKLE WILLIAM GEORGE 摘要:This invention relates to novel compounds which are useful in the modulation of endogenous growth hormone levels in a mammal. The invention further relates to novel intermediates for use in the synthesis of said compounds, as well as novel processes employed in these syntheses. Also included are methods of treating a mammal which include the administration of said compounds.
专利号:US-2009088571-A1 优先权日:2004-07-27 标题 :Synthesis of 6,7-Dihydro-5H-imidazo[1,2-a]imidazole-3-sulfonic acid amides
[参考文献]: Andrew M Thompson, Et Al. Synthesis, Reduction Potentials, And Antitubercular Activity Of Ring A/b Analogues Of The Bioreductive Drug (6S)-2-Nitro-6-{[4-(Trifluoromethoxy)Benzyl]Oxy}-6,7-Dihydro-5H-Imidazo[2,1-B][1,3]Oxazine (Pa-824). J Med Chem. 2009 Feb 12;52(3):637-45.
合成参考文献
摘要:Kim, H.; Yoshida , J., Science of Synthesis: Flow Chemistry in Organic Synthesis, (2018) 1, 228.