CAS: 555-68-0; 3-Nitrocinnamic Acid

上下游产品

CAS号99-61-6 间硝基苯甲醛 | CAS号64-19-7 冰醋酸 | CAS号141-82-2 丙二酸 | CAS号645-00-1 1-碘-3-硝基苯 | CAS号79-10-7 丙烯酸 | CAS号113-24-6 丙酮酸钠 | CAS号110-89-4 六氢吡啶 | CAS号108-24-7 乙酸酐 | CAS号24163-36-8 Iodonium, bis(3... | CAS号68444-12-2 sodium alpha-hy... | CAS号5396-71-4 3-硝基肉桂酸乙酯 | CAS号151539-32-1 8-[(E)-2-(3-nit... | CAS号147700-41-2 7-methyl-8-[(E)... | CAS号60-35-5 乙酰胺 | CAS号99-61-6 间硝基苯甲醛 | CAS号298-12-4 乙醛酸 | CAS号121-92-6 间硝基苯甲酸 | CAS号882-26-8 beta,3-二硝基苯乙烯 | CAS号586-39-0 3-硝基苯乙烯

2,3-Dibromo-3-(3-Nitro-Phenyl)-Propionic Acid Ethyl Ester 反应生成 间硝基肉桂酸
参考文献:Wollring,Chemische Berichte,1914,Vol. 47,P. 114
标题:Wollring,Chemische Berichte,1914,Vol. 47,P. 114

专利信息

专利号:US-2005080260-A1
优先权日:2003-04-22
标 题 :Preparation of prodrugs for selective drug delivery
发明人：MILLS RANDELL L; WU GUO-ZHANG
摘要:Synthesis of a chemical compound having the formula A-B-C that may serve for applications such as drug delivery where A is a chemiluminescent, moiety, B is a photochromic moiety, and C is a biologically active moiety where A-B-C may serve as a prodrug. Novel synthetic methods of the present invention to form the prodrug comprised the steps of (1) forming a benzophenone, (2) forming a diaryl ethylene, (3) attaching a phthalimide moiety to at least one of the aryl groups of the ethylene to form a phthalimide-ethylene conjugate, (4) condensing two ethylene-phthalimide conjugates to form a phthalimide-pentadiene conjugate, (5) converting the phthalimide to the phthalhydrazide by reaction with hydrazine to form a carrier compound according to the present invention, and (6) reacting the carrier compound with an nucleophilic moiety of the drug to form the corresponding prodrug. Alternatively the carrier can be prepared by using the halo-substituted diaryl ethylene to make the corresponding cationic leuco dye-like compound with known methods. The cationic compound then is protected by reacting with a nucleophile and coupled with the aminophathalimide by palladium-catalyzed amination to form the protected phthalimide-pentadiene conjugate. The latter is refluxed with hydrazine to convert its phthalimide to the phthalhydrazide and acidified to give the carrier. An additional aspect of the present invention relates to the use of these compounds as antiviral agents for the treatment of viral infections such as HIV and as anticancer agents for the treatment of cancers such as bowel, lung, and breast cancer.

专利号:US-6531470-B1
优先权日:1998-01-23
标题:Oxazolidinone combinatorial libraries, compositions and methods of preparation
发明人：GORDEEV MIKHAIL F; LUEHR GARY W; PATEL DINESH V; NI ZHI-JIE; GORDON ERIC
权利人:UPJOHN CO
摘要:Oxazolidinones and methods for their synthesis are provided. Also provided are combinatorial libraries comprising oxazolidinones, and methods to prepare the libraries. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising the oxazolidinones. The methods of library preparation include the attachment of oxazolidinones to a solid support. The methods of compound preparation in one embodiment involve the reaction of an iminophosphorane with a carbonyl containing polymeric support.

专利号:US-6562844-B2
优先权日:1998-01-23
标 题:Oxazolidinone combinatorial libraries, compositions and methods of preparation
发明人：GORDEEV MIKHAIL F; LUEHR GARY W; PATEL DINESH V; NI ZHI-JIE; GORDON ERIC
权利人:UPJOHN CO
摘要:Oxazolidinones and methods for their synthesis are provided. Also provided are combinatorial libraries comprising oxazolidinones, and methods to prepare the libraries. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising the oxazolidinones. The methods of library preparation include the attachment of oxazolidinones to a solid support. The methods of compound preparation in one embodiment involve the reaction of an iminophosphorane with a carbonyl containing polymeric support.

专利号:US-7002020-B1
优先权日:1998-01-23
标题:Oxazolidinone combinatorial libraries, compositions and methods of preparation
发明人：GORDEEV MIKHAIL F; LUEHR GARY W; PATEL DINESH V
权利人:UPJOHN CO
摘要:Oxazolidinones and methods for their synthesis are provided. Also provided are combinatorial libraries comprising oxazolidinones, and methods to prepare the libraries. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising the oxazolidinones. The methods of library preparation include the attachment of oxazolidinones to a solid support. The methods of compound preparation in one embodiment involve the reaction of an iminophosphorane with a carbonyl containing polymeric support.

专利号:US-4742084-A
优先权日:1983-11-21
标 题 :Aralykyl (arylethynyl)aralkyl amines and their use as vasodilators and antihypertensives
发明人：CARSON JOHN R
权利人:MCNEILAB INC
摘要:Acetylenes of the formula (I): (I) wherein Y, m, R1, R2, q, Alk, R3 n and R4 are as defined herein and Ar1 and Ar2 are aromatic, including the salts and ammonium derivatives of formula (I), in treating angina, hypertension and cardiac arrhythmias. Pharmaceutical compositions, methods of use and synthesis and novel intermediates are also part of the invention.

专利号:US-4661635-A
优先权日:1983-11-21
标题 :Aralykyl (arylethynyl)aralkyl amines and their use as vasodilators and antihypertensives
发明人：CARSON JOHN R
权利人:MCNEILAB INC
摘要:Acetylenes of the formula (I): (I) wherein Y, m, R1, R2+L, q, Alk, R3, n and R4 are as defined herein and Ar1 and Ar2 are aromatic, including the salts and ammonium derivatives of formula (I), in treating angina, hypertension and cardiac arrhythmias. Pharmaceutical compositions, methods of use and synthesis and novel intermediates are also part of the invention.