CAS: 586-78-7; 1-Bromo-4-Nitrobenzene

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CAS号100-01-6 对硝基苯胺 | CAS号106-40-1 对溴苯胺 | CAS号456-27-9 对硝基苯四氟硼酸重氮盐 | CAS号108-86-1 溴苯 | CAS号943-14-6 2-溴-5-硝基苯甲酸 | CAS号5467-74-3 4-溴苯硼酸 | CAS号1947-33-7 4-methylbenzene... | CAS号7227-92-1 1-Triazene,3,3-... | CAS号636-98-6 4-硝基碘苯 | CAS号10565-13-6 2-(4-硝基苯基)丙二酸二乙酯 | CAS号453562-77-1 2-methyl-2-(4-n... | CAS号10326-99-5 2-methyl-1-(4-n... | CAS号1093878-42-2 4-(4-溴苯基)硫代吗啉-1... | CAS号10468-46-9 N-(4-bromopheny... | CAS号4316-57-8 4-硝基三苯胺 | CAS号4282-47-7 2-(4-硝基苯基)吡啶 | CAS号5397-76-2 吗啉基(4-硝基苯基)甲酮 | CAS号56705-83-0 [4-(2-甲基苯氧基)苯基]胺

对二硝基苯置于高氯酸,硫酸,Sodium Nitrite,氢溴酸,铜体系中,用 水,乙酸乙酯 作为反应溶剂,以67%的收率获得产物1-溴-4-硝基苯
参考文献:芳基重氮盐的两相电化学反应生成:在电反应生成的铜催化的桑德迈尔反应中的应用.
标题:芳基重氮盐的两相电化学反应生成:在电反应生成的铜催化的桑德迈尔反应中的应用.
摘要:首次报道了在两相系统(乙酸乙酯/水)中由硝基芳烃电化学反应生成芳基重氮盐.以非常好的收率和非常好的纯度制备了包括偶氮,偶氮砜和芳基叠氮化物在内的一些化合物.阴极产生的芳基重氮和阳极产生的铜(i)离子用于进行sandmeyer反应.为了改进该方法,引入了以zn棒为阳极的h型自驱动电池,并将其用于两相芳基重氮的生产.
DOI:10.1021/acs.Orglett.0C02013

专利信息

专利号:US-11938187-B2
优先权日:2021-06-10
标题:Methods and compositions for synthesis of two-photon cleavable phosphoramidite molecules for oligonucleotide conjugation
发明人：LO PEGGY PIK KWAN; LIU LING SUM; TAM DICK YAN
权利人:UNIV CITY HONG KONG
摘要:The syntheses of two phosphoramidite building blocks based on BNSF and BNSMB structures are disclosed. Furthermore, some common molecular intermediates have been designed and linked to the central biphenyl core of the two molecules, resulting in a versatile and cost-effective design. These compounds can be effectively introduced to DNA oligonucleotides via the well-established standard cyanoethylphosphoramidite chemistry on the nucleic acid synthesizer. Fragmentation of these BNSF- and BNSMB-functionalized DNA strands is achieved by both one-photon and two-photon photolysis of photoliable bonds of [2-(2-nitrophenyl)propoxy]carbonyl groups on BNSF and BNSMB molecules respectively, resulting in two short pieces of single-stranded DNAs. The versatile design and facile synthesis of these two-photon photocleavage phosphoramidite molecules are beneficial to synthetic chemists and photochemists for the development of new caged compounds which enables to introduce into oligonucleotides as light-triggered carriers via solid-phase synthesis for a wide range of applications in materials science, polymer, chemistry, biology and DNA nanoecthnology.

专利号:EP-0842924-B1
优先权日:1996-11-14
标 题 :Pyridine intermediates, useful in the synthesis of beta-adrenergic receptor agonists
发明人：WRIGHT STEPHEN WAYNE
权利人:PFIZER
摘要:The present invention relates to certain compounds of the formula (I), which are useful in the synthesis of certain beta -adrenergic receptor agonists. The invention also relates to a process for synthesizing the compounds of formula (I) and to compounds of the formula (II), wherein R<1>, R<2> and R<4> are defined herein, which are useful in the synthesis of the compounds of formula (I). The invention also relates to a process for synthesizing a compound of formula (II). The invention further relates to processes for synthesizing compounds of formula (Z*), R<1>, R<2> and Y<2*> are defined herein.o

专利号:US-8304550-B2
优先权日:2007-11-30
标题 :Process for the catalytic synthesis of diaryl ethers
发明人：COTTE ALAIN; MULLER NIKOLAUS; GOTTA MATTHIAS; BELLER MATTHIAS; SCHAREINA THOMAS; ZAPF ALEXANDER
权利人:COTTE ALAIN; MULLER NIKOLAUS; GOTTA MATTHIAS; BELLER MATTHIAS; SCHAREINA THOMAS; ZAPF ALEXANDER; SALTIGO GMBH
摘要:Described is a process for preparing diaryl ethers of the formula (I)n nAr—O—Ar′  (I)n n In which Ar is an aryl or substituted aryl group and Ar′ is an aryl, substituted aryl, heteroaryl or substituted heteroaryl group, n by reacting an aryl of formula (II) or a aryloxy salt of formula (III)n nAr—OH  (II)n nAr—OR  (III)n n In which Ar has the same meaning as in formula (I) and R is an alkali metal, n with an aryl or heteroaryl bromide of formula (IV)n nAr′—Br  (IV)n n In which Ar′ has the same meaning as in formula (I), n characterized in that the reaction is carried out in the presence of a copper(I)salt and a 1-substituted imidazole as catalyst system.

专利号:US-5254776-A
优先权日:1992-07-17
标 题:Synthesis of bromobiphenyls
发明人：LANG JOHN F; GURUSAMY NARAYANASAMY
权利人:MALLINCKRODT SPEC CHEM
摘要:Bromobiphenyls (such as 2-fluoro-4-bromobiphenyl) are synthesized by reacting together a phenylboronic acid (such as phenylboronic acid) and a bromoiodobenzene (such as 2-fluoro-4-bromoiodobenzene). The reaction generally takes place with the aid of a catalyst (such as palladium in a zero valance state) and an inert solvent (such as fluorobenzene). Control of temperature is very important to obtain both an acceptable reaction rate and an acceptable level of terphenyl byproduct.

专利号:US-7517828-B2
优先权日:2003-04-25
标 题 :Chiral broensted acid catalyst for asymmetric synthesis and method of asymmetric synthesis with the catalyst
发明人：AKIYAMA TAKAHIKO
权利人:TOAGOSEI CO LTD
摘要:A compound usable as an asymmetric synthesis catalyst which can be easily synthesized without using any metal such as a lanthanoid group element; a method of asymmetric synthesis with the compound; and a chiral compound obtained by the asymmetric synthesis method. A Broensted acid is used as a catalyst in asymmetric synthesis, the chiral Broensted acid being represented by formula (1) below or formula (3) below. The asymmetric synthesis method employs the catalyst. Asymmetric synthesis with the catalyst gives a chiral compound.

专利号:US-8008526-B2
优先权日:2005-03-17
标 题 :Synthesis reaction catalyst and method of synthesizing compound using the same
发明人：TANAKA HIROHISA; KANEKO KIMIYOSHI
权利人:DAIHATSU MOTOR CO LTD; HOKKO CHEM IND CO
摘要:To improve a catalytic activity of a composite oxide, to carry out a reaction in a high yield, and to provide a synthesis reaction catalyst having excellent handling properties and a method of a synthesizing a compound using the same, a synthesis reaction catalyst containing a palladium-containing perovskite-type composite oxide having a specific surface area of 0.5 to 9.5 m 2 /g is used in Suzuki Cross-Couplings given by the following general scheme (14).